Tuesday, February 14, 2023


Booster Shots May Trigger Stroke Incidents, According to CDC and FDA

In addition to cardiac events, another life-threatening side effect has been associated with the Pfizer-BioNTech vaccine. When is the risk period? Does the flu shot play any role in these events? What actions should we take to better protect ourselves?

Summary of Key Facts

An increased risk of stroke events has been identified with the Pfizer COVID-19 bivalent vaccine, according to a joint statement from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA).

The onset time in people aged 65 years and older was 1–21 days after the booster, with a significant cluster of events observed 11–21 days after the booster.

Sixty-four percent had received the flu vaccine on the same day as the COVID-19 booster.

The bivalent booster contains the code of the spike protein, contributing to the increased risk of blood clots. High-risk people should avoid the boosters.

Solution: Remember the five “suddens” of stroke warning signs.

Advice on preventing other risk factors of stroke is also provided in this paper.

On Jan. 13, 2023, the FDA and CDC issued a joint statement that a new “safety signal” for ischemic stroke had been detected in one of the agency’s vaccine safety surveillance systems.

The statement read, in part: “CDC’s Vaccine Safety Datalink (VSD), a near real-time surveillance system, met the statistical criteria to prompt additional investigation into whether there was a safety concern for ischemic stroke in people ages 65 and older who received the Pfizer-BioNTech COVID-19 vaccine bivalent.”

The VSD system monitors the electronic health records of 12.5 million Americans served by nine integrated health systems.

The CDC stated that no other safety databases had detected this signal (including the Medicare and Veterans Affairs data sets). Pfizer released a statement that it had not detected this signal in its databases, and no other countries have found a similar signal in their monitoring systems.

The clot risk appears to be greater on days 11–21 after receiving the booster, especially for those who received a high-dose or adjuvant flu vaccine on the same day.

A follow-up meeting was held on Jan. 26, 2023. Despite the identified risk, the CDC continues to recommend booster shots for all people over six months of age.

Increased Risk of Stroke Mostly Found 11 to 21 Days After Booster

The findings presented on Jan. 26, 2023, suggest that more stroke events occurred during days 1–21 post-vaccination than days 22–42 after receiving the shot.

People aged 65 or older who received the Pfizer bivalent booster experienced 130 events during the “risk interval” (1–21 days after the booster) and 92 events during the “comparison interval” (22–42 days after the booster). There was a 47 percent increased risk of ischemic stroke during 1-21 days post-booster, compared to those events occurring during 22-42 days post-booster, with a p = 0.005. In studies, when the P value is less than 0.05, it means the difference is statistically significant.

It is important to note that stroke events occurred throughout the entire 42-day follow-up period after the booster; a cluster of stroke events occurred between 11 and 21 days after receiving the booster.

In a preliminary review of 22 stroke cases in people 65 years or older on days 11–21 after receiving the booster, none of the individuals had a previous history of transient ischemic attack (TIA). Sixty-four percent received the flu vaccine on the same day as the COVID-19 booster (13 high-dose flu vaccines and one adjuvant flu vaccine).

Outcome data of these events shows that 59 percent of the people who experienced a TIA were discharged home, 18 percent were discharged with home health, nine percent were discharged to a skilled nursing facility, and 14 percent (three of the 22) died. The CDC notes that one death was likely related to a stroke.

No safety signal was detected in the VSD database for Moderna; however, the VAERS reported stroke cases related to the Moderna booster. The difference could be due to the number of booster doses administered for the two vaccines. Nearly twice as many Pfizer booster doses had been given as Moderna (549,943 vs. 285,706) as of Jan. 7, 2023.

As of Jan. 8, 2023, 40 ischemic stroke/transient ischemic attack cases after the bivalent COVID-19 mRNA vaccination were detected in the Vaccine Adverse Events Reporting System (VAERS). The median age was 74 years. Nineteen were males, and 21 were females. The median time to onset was four days. Twenty-five cases occurred after the Pfizer-BioNTech bivalent vaccine, and 15 occurred after the Moderna bivalent vaccine.

Receiving a Flu Shot on the Same Day as the Booster Increases Risk

VSD data analysis showed that three people experienced a stroke after receiving the Pfizer booster and a standard dose of flu vaccine on the same day. By contrast, 40 people who received the Pfizer booster and a high-dose or adjuvant flu vaccine on the same day experienced a stroke. Sixty older adults experienced a stroke after receiving only the COVID-19 booster.

Receiving a high dose or adjuvanted flu shot on the same day seemed to double the risk of stroke.

The spike protein in the SARS-CoV-2 virus can significantly increase the risk of arterial and venous clots. A database analysis of 48 million individuals in the United Kingdom found an increased risk of ischemic stroke, especially in the first weeks after COVID-19 infection.

The mRNA vaccine also produces the spike protein. The bivalent booster contains the code for two strains of the spike protein (original Wuhan strain and BA.4/BA.5).

Your blood contains platelets, which form clots to stop bleeding after an injury. The S1 unit of the spike protein hyperactivates these platelets. This can cause the blood to form tiny clots after infection or vaccination. These blockages in blood flow can cause problems throughout the body’s tissues and organs.

The flu shot increases the risk of stroke, possibly because the vaccine provokes an inflammatory response. This increases the risk of ischemic stroke, especially in people with pre-existing coagulation abnormalities. A report from Taiwan indicated that a 75-year-old male patient suffered posterior circulation ischemia after an influenza A/H1N1 vaccination.

Remember the ‘FAST’ Rule

Ischemic stroke occurs when a blood clot blocks or narrows an artery that leads to or is inside the brain. A blood clot often forms in arteries damaged by the buildup of plaques (atherosclerosis). It can occur in the carotid artery of the neck as well as in other arteries.

After vaccination—at a very rare rate—if an adverse stroke event does appear, what signs can alert you in time?

There are five “suddens” of stroke warning signs. If you observe one or more of these signs of a stroke, don’t wait; call a doctor or 911 immediately!

Sudden numbness, weakness, or tingling of the face, arm, or leg, especially on one side of the body

Sudden confusion, drowsiness, or trouble talking or understanding speech

Sudden trouble seeing in one or both eyes, or double vision

Sudden trouble walking, dizziness, or loss of balance or coordination

Sudden severe headache, nausea, or vomiting with no known cause

Sometimes the signs may last only a few moments and then disappear. These episodes, known as transient ischemic attacks or TIAs, are called “mini-strokes.” Paying attention to them can be life-saving.

Remember the FAST (face, arm, speech, time) rule.

F ace drooping? Can’t smile
A rm weakness? Can’t raise above head
S peech difficulty? Can’t repeat simple nursery rhyme
T ime to call 911.

One or more of these signs—face weakness, arm weakness, and speech difficulty—are present in 88 percent of all strokes and TIAs. Getting to an emergency room quickly can save your life or the life of a loved one.

An intravenous injection of recombinant tissue plasminogen activator (rtPA) is the gold standard treatment for selected patients with ischemic stroke. An injection of TPA is usually given through a vein in the arm within the first three hours after a stroke.

Arriving at an emergency room as quickly as possible after noticing symptoms is critical to reducing the odds of disability. A successful rescue of stroke patients includes early identification of signs of stroke and medical care within the first hour of acute stroke.

Recommendations on Vaccinations

It may not be advisable for individuals vaccinated against COVID-19 and who experienced a stroke to take extra COVID-19 jabs such as boosters.

For now, this safety signal looks like a worrisome association with vaccination. Elderly individuals at high risk for severe COVID-19 should check with their physicians for the most appropriate guidance tailored to their risks, given that COVID-19 also increases the risk of stroke and other cardiovascular events for months after infection.

Carefully monitor individuals who received the COVID-19 vaccine or flu vaccine, especially those with high ischemic stroke risk.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Monday, February 13, 2023


Unmasked: the failure of Covid mandates

No nation forced masks on people with as much zeal as the US, whose libertarian reputation belied pockets of maniacal health authoritarianism unknown in Australia or even Europe.

The US, uniquely among advanced nations, forced masks on children aged two and up, something not even Victoria countenanced at the height of the great madness.

Today, still, after the vast bulk of Americans has sheepishly consigned masks to the bin, school students in Michigan and Massachusetts are required to mask up in class, despite mounting evidence that masks stunt childhood development.

In that context, a new, rigorous study that found masks did nothing to slow Covid-19 might have made the news. But no; a 305-page Cochrane analysis published globally on January 30 that assessed 78 high-quality scientific studies that included more than 610,000 participants has yet to rate a single mention in The Washington Post, The New York Times or on CNN, for instance.

Even passionate maskers, such as Baltimore epidemiologist Jennifer Nuzzo, conceded Cochrane reviews were the “gold standard” of evidence-based medicine and its latest mask study “a very serious undertaking”.

Cochrane found that surgical masks, the kind doctors wear in operating theatres to avoid accidentally sneezing into an open wound, did nothing to stop Covid-19.

More embarrassing for Team Mask, those even more uncomfortable N95 masks made little to no difference either. Only hand washing seemed to work to prevent the spread of corona and influenza-like viruses.

“There is just no evidence masks make any difference. Full stop,” University of Oxford associate tutor Tom Jefferson, one of the study’s 12 authors, told Australian journalist Maryanne Demasi last week.

“In the absence of evidence, you shouldn’t be forcing anybody to do so,” he said, describing advocates of forced masking as “activists, not scientists”.

It turns out the billions upon billions of masks that were manufactured in response to government mandates and now are floating in oceans or piling up at rubbish tips were likely to have been a colossal waste. American multinational 3M alone produced 4.5 billion N95 masks in 2020 and 2021, according to Statista; the mind boggles at what the global total for all masks might be.

“Governments completely failed to do the right thing and demand better evidence,” Jefferson says. “At the beginning of the pandemic there were some voices who said masks did not work and then suddenly the narrative changed.”

Thankfully, the narrative is changing again, in part to a US House of Representatives Repub­lican majority that is determined to probe some of the madder aspects of the great madness.

“I had doctors who spent years in medicine telling me masks were not effective, and yet these were being forced on people and school kids,” Republican congressman Gary Palmer said last week at a congressional hearing that included US Centres for Disease Control and Prevention director Rochelle Walensky. “We’re seeing a devastating impact on their educational attainment, so it surprises me that the CDC didn’t do any follow-up testing even while this was going on.”

Surprisingly, no government health agency in the US or elsewhere bothered to conduct any randomised control trial of what was a highly divisive intervention that pre-2020 science had counselled against.

Walensky said she didn’t rate the latest Cochrane study because it analysed only the highest quality mask studies. “I’m not sure anybody would have proposed a clinical trial because so many studies demonstrated time and time again … masks were working,” she said in reply, referring to studies that would have been deemed junk before 2020.

Indeed, none of the findings in the latest Cochrane review should have been a surprise. The overwhelming consensus among scientists pre-Covid-19 was that forcing healthy people to wear masks, let alone outside, was pointless and potentially harmful. Minuscule viruses would slip through the tiny holes in the masks or simply go around them.

As late as March 31, 2020, the World Health Organisation was sticking to the old science.

“There is no specific evidence to suggest that the wearing of masks by the mass population has any potential benefit. In fact, there’s some evidence to suggest the opposite in the misuse of wearing a mask properly or fitting it properly,” WHO health emergencies program executive director Mike Ryan told journalists.

But a few weeks later, following a total of zero new studies, “the science” had emerged in all its authoritarian glory, deeming masks effective and forcing them on hundreds of millions of people against their will for up to two years. Masks might have failed totally at stopping Covid-19 surges in every nation that implemented them, but they were highly successful on one metric: stoking fear, providing an in-your-face, everyday reminder of the pandemic that might increase compliance with other measures.

At the same time the incentive structure for researchers, who previously had toiled largely in obscurity, changed dramatically in the first half of 2020. Fame, speaking fees, academic promotion – all were in the offing for the canny researcher who could help demonise anyone who pointed to pre-2020 science or simply preferred to risk getting a bad cold rather than wear a mask.

Governments and their media cheer squad were eager to promote studies that vindicated mandatory masking.

That’s what explains the contemptible silence following the latest Cochrane review.

Wearing a mask sent a powerful message throughout the pandemic: I follow the science. Increasingly, it’s sending a different one: I’m a credulous goose. Or perhaps even, following new research in Frontiers in Psychology published last month: I’m not very attractive.

“Our results consistently demonstrated that self-perceived unattractive individuals were more willing to wear a mask, as they believed it would benefit their attractiveness,” the authors concluded.

To be sure, it wasn’t a randomised control trial but it reveals at least as much truth as any post-2020 study telling you masks worked.

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Covid’s devastating impact on the heart as lockdowns take a triple toll on the health of the nation

New heart research confirms fears COVID-19 has taken a devastating toll on the health of Australians after confining them indoors, deprived of opportunities to exercise and exposed to poor diets and sleep routines.

Almost half of more than 6000 people who have undergone Victor Chang Heart Health Checks since the start of the pandemic have recorded results considered outside the healthy range.

A specialist team which conducts a mobile testing service across Australia has found cholesterol, blood sugar and blood pressure levels all significantly higher since COVID arrived.

The number of people having at least one test result outside the healthy range since March 2020 increased from 33 per cent to 47 per cent - a relative jump of more than 40 per cent.

Victor Chang Cardiac Research Institute Program manager Anastasia Dounas says for many the COVID effect was real and of serious concern. 'They got out of the habit of going to the gym during lockdown and ate and drank more because they were worried and stressed, leading to weight gain,' she said.

'Working from home also led to less incidental exercise and the fear of COVID saw more people choosing to drive to work than catching public transport which resulted in people taking fewer steps each day. 'That all adds up.'

Since the launch of the heart check program in 2011 until the onset of COVID in 2020, more than 76,000 participants have been tested with just over a third having one or more results outside the normal healthy range and advised to follow up with a GP.

Within this group, eight per cent were beyond the healthy limit for blood pressure and blood sugar, and almost 30 per cent for cholesterol.

Since March 2020, 6182 participants have been tested with just over 47 per cent having one or more results outside the healthy range and advised to see their doctor.

Of these, 15 per cent were on the wrong side of healthy for blood pressure, 10.5 per cent for blood sugar and 32 per cent for cholesterol.

Heart check nurse Clare Lennon said it was more important than ever to be assessed and start re-engaging with exercise and a healthy diet.

'Heart health checks are vital in revealing if you are at risk of heart disease but can also help prevent it,' she said.

'Lifestyle changes or medications can make a huge difference to risk factors but you need to be aware of whether you have high cholesterol, blood pressure, or blood sugar to begin with.'

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Sunday, February 12, 2023



CDC Adds COVID-19 Vaccines to Child Immunization Schedule

This is alarming. How would you feel if your baby died of a shot? Vaccines can kill and a baby's immune system is immature so babies may be especially vulnerable

The U.S. Centers for Disease Control and Prevention (CDC) added COVID-19 vaccines to its routine immunization schedule for children and adults on Thursday, attracting criticism for the decision.

According to the CDC’s 2023 immunization schedule for children and adolescents, two or three doses of COVID-19 vaccines have been recommended beginning with infants who are just six months old. Children in the age group of 6 months to four years, and five years to 11 years are recommended COVID-19 vaccines from Moderna or Pfizer. Among children aged 12 to 18, Novavax vaccines are also recommended in addition to Pfizer and Moderna.

In the list for adults, two or three doses of COVID-19 vaccines have been recommended from the age of 19 years. The 2023 COVID-19 vaccine recommendation for kids and adults is included among other typically-recommended vaccines for measles, flu, rubella, and so on.

Advisers to the CDC in 2022 recommended adding the vaccines to the schedule.

Though the CDC has added COVID-19 vaccines to the recommended list, it has not mandated the vaccines. The agency does not have the authorization to do so, but local and state jurisdictions can, and many mandate most of the vaccines on the schedule. However, there are hardly any states that make flu vaccinations mandatory in public schools.

Lawyers have said they’ll sue any state that requires COVID-19 vaccination to attend school and many officials have vowed not to implement such a requirement.

The CDC’s move to add COVID-19 vaccines to immunization schedules has attracted criticism online.

“While I thought impossible for @CDCgov to lose anymore credibility—they decide to do this despite growing studies showing declining efficacy, no net benefit for majority of immunocompetent” individuals, anesthesiologist Megan Martin said in a Feb. 10 tweet.

Vaccine Injury Compensation For COVID-19

The children’s vaccine schedule points out that COVID-19 vaccines are not covered by the National Vaccine Injury Compensation Program (VICP), a no-fault alternative to the traditional legal system for resolving vaccine injury petitions.

Instead, COVID-19 vaccines authorized or approved by the Food and Drug Administration (FDA) are covered by the Countermeasures Injury Compensation Program (CICP).

Created in 2010, the CICP is a compensation program aimed at vaccines and medications which are developed as a response to any public health emergency.

Claimants must file a request for compensation within a year of being injected with the vaccine. The program, mostly intended for children’s vaccines, is known to be more arduous and less generous than VICP.

Without the development of a vaccine injury table by the Health Resources and Services Administration (HRSA), the burden of proof lies with the petitioner and not the government to prove causation in order to establish eligibility.

An analysis by Bloomberg shows that while the average compensation payout under VICP is around $533,000, the payout under CICP is just above $200,000. VICP guarantees legal representation and hearing for claimants. Individuals applying under CICP do not get these benefits. While decisions made by VICP officials are made public, CICP decisions are never known.

“Agency officials decide the claims in secret, without the opportunity for injured individuals or their families to speak with or interact with decision makers,” Nora Freeman Engstrom, a professor at Stanford Law School who researches vaccine injury compensation programs, said to the outlet.

Since CICP decisions remain unpublished, “the public and researchers can’t know which adverse events were found with vaccines and which were not … This has the potential to stunt our understanding of these vaccines’ safety and efficacy,” she stated.

COVID-19 Vaccine Injuries

According to a recent study from the CDC, more than 1,600 children between the ages of five and 11 experienced a systemic reaction like diarrhea or fever after receiving a dose of COVID-19 vaccines.

Almost half of the children in the study who received updated Pfizer and Moderna vaccines were found to have experienced a systemic reaction, which is defined as “usually mild” reactions that last for multiple days. Systemic reactions are rated above local reactions on the severity scale, just below severe reactions.

In a Feb. 1 paper, the CDC reported that 73 cases of Guillain-Barre Syndrome were identified in adults within 42 days of taking a Johnson & Johnson COVID-19 shot.

The syndrome causes the body’s immune system to attack certain parts of the nervous system. Based on the usual annual rate of the syndrome, only 31 cases were expected.

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Study: Heart attacks increased among young people post-COVID

What percentage of those who died were vaccinated is not said

A recent study has found that the number of deaths from heart attacks increased since the COVID-19 pandemic began.

The increase was more pronounced in people aged between 25 and 44. A 29.9% relative increase in heart attack deaths (about 30% higher than the predicted number) was observed in this age group over the first two years of the pandemic.

Cardiologist Dr. Susan Cheng, a study co-author, told TODAY, “Young people are obviously not really supposed to die of heart attack. They’re not really supposed to have heart attacks at all.”

The relative increase in heart attack deaths among adults between 45 and 64 was 19.6%, and 13.7% for adults 65 and older.

This increase also coincided with COVID-19 surges in the country. Los Angeles County paramedic Romeo Robles told TODAY that such surges would often lead to an increase in emergency calls related to heart issues, even among young people.

Cheng pointed out that the connection is surely “more than coincidental,” since COVID-19 can have a significant impact on the cardiovascular system. She said that the illness appears to increase “the stickiness of the blood,” the probability of “blood clot formation,” blood pressure spikes, and “an overwhelming stress.”

While the reason for the increased rate in young people is still unclear, the study authors posited a theory. Cheng said that young people were more likely to have stronger immune systems which could also lead to an excessive response to the virus.

A February 2022 study of over 150,000 individuals with COVID-19 revealed that COVID-19 survivors are at “substantial” risk of developing heart disease even a year after infection, regardless of their symptoms’ severity and risk factors.

Physician-scientist Dr. Ziyad Al-Aly, a study co-author, estimated that around 4% of people who had COVID-19 will develop a heart issue that ranges from an irregular heartbeat and inflammation to heart attacks and heart failure.

The risk also increases with each COVID-19 infection an individual experiences.

If you have been infected before, especially multiple times, Cheng advised improving your health and monitoring your risk factors, such as blood sugar, blood pressure, and cholesterol.

Heart attack signs to look out for include: pain, discomfort, or pressure in the chest area; pain or discomfort in the neck, jaw, or back; cold sweat; weakness, light-headedness, or fainting; and shortness of breath.

The study noted that the number of heart attacks has been previously decreasing in the country, but the trend increased again since the pandemic.

The study by Cedars Sinai hospital in Los Angeles was published in September 2022.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Friday, February 10, 2023


University of Sydney scientists make ‘crazy’ Covid-19 discovery

The COVID public health emergency is coming to an end, and even thought you might not have been following protocols recently, this will still affect you and your wallet.
Australian scientists have made an incredible discovery that could change the way we view Covid — and could explain why some people suffer serious illness with the virus, or even death, while others never get sick or appear symptomless.

University of Sydney researchers discovered a protein in the lung that blocks Covid infection and forms a natural protective barrier in the human body.

The naturally occurring protein, LRRC15, works by attaching itself to the virus, stopping Covid particles from binding with more vulnerable cells - as well as reducing the chance of infection.

The research offers a promising pathway to develop new drugs to prevent Covid or deal with fibrosis in the lungs.

The study led by Professor Greg Neely found that this new receptor acts by binding to the virus and sequestering it which reduces infection.

“For me, as an immunologist, the fact that there’s this natural immune receptor that we didn’t know about, that’s lining our lungs and blocks and controls viruses, that’s crazy interesting,” Professor Neely said.

“We can now use this new receptor design broad acting drugs that can block viral infection or even suppress lung fibrosis.”

How it works

The Covid-19 virus infects humans by using a spike protein to attach to a specific receptor in our cells. It primarily uses a protein called the angiotensin-converting enzyme 2 (ACE2) receptor to ender human cells.

Lung cells have high levels of ACE2 receptors, which is why the Covid-19 virus often causes severe problems in this organ.

Like AEC2, LRRC15 is a receptor for Covid meaning the virus can bind to it. But unlike ACE2, LRRC15 does not support infection.

It can however stick to the virus and immobilise it.

Researchers believe patients who died from Covid did not produce enough of the protein, or produced it too late to make a difference.

“We think it acts a bit like Velcro, molecular Velcro, in that it sticks to the spike of the virus and then pulls it away from the target cell types,” another researcher Dr Lipin Loo said.

The breakthrough comes as millions of Australians are now eligible for a fifth Covid vaccine within a fortnight.

The Australian Technical Advisory Group on Immunisation has recommended that all people aged 18 and over receive a top-up jab, no matter how many doses they’ve already received, as long as they have not been infected with the virus in the last six months.

Up to four million Australians are estimated to have been struck down with Covid-19 just in the past four months.

More than 2600 Australians have died with the virus since October. Around 800 of those deaths were aged care residents.

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Can Plant Extracts Effectively Inhibit SARS-CoV-2—The Results of a Portugal Review Study Look Promising

Can natural products be used as a means of combating COVID-19? Afterall, plant-based chemistry has been at work in Traditional Chinese Medicine (TCM) for centuries, based on plants: long the source of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses.

In fact, natural extracts have demonstrated potential efficacy against various pathogens in the coronavirus families, although that fact isn’t touted much by mainstream media in the West. But plenty of misinformation associated with this topic continues to circulate across cyberspace. There are reasons medical products are tightly regulated at the national level.

Only after careful and systematic research demonstrating safety and effectiveness will such natural products be authorized by relevant authorities. In that spirit, recently, a group of collaborating scientists from Portugal, affiliated with the Mountain Research Institute and the Catholic University of Portugal (Center for Biotechnology and Fine Chemistry), investigated select plant metabolites and their potential therapeutic value targeting SARS-CoV, the virus behind COVID-19.

Of particular interest to the Portugal-based scientists, represented by corresponding author Lillian Barros, Ph.D., a biotech engineer with a focus on biotechnology and food chemistry, was a couple of molecules associated with Traditional Chinese Medicine (TCM) as the world’s biggest population depends heavily on this approach targeting COVID-19.

What are the primary strategies to inhibit or stop SARS-CoV-2, the virus behind COVID-19?

Researchers have determined a couple pathways for therapy to work, including 1) inhibiting of SARS-CoV-2 penetration by preventing SARS-CoV-2 S-ACE2 binding interactions and 2) the inhibiting of protease enzymes such as Mpro (main protease), 3CLpro (3C-like protease) and PLpro (papain-like protease).

Enter this investigation into plant metabolites targeting SARS-CoV-2

The study team centered their investigation on select plants associated with TCM, for example, and the derived molecules that can actually bind with glycoprotein and consequently stop membrane fusion included A) luteolin (11 µM) and TGG (tetra-O-galloyl-β-D-glucose, 5.0 µM), both taken from TCM that do bind with spike glycoprotein. The team looked at other plant-based molecules.

The study team used the SCOPUS database and associated software to better understand a relation between plants and SARS-CoV02. They report about 1504 documents surfaced based on targeted keywords from 2020 to 2022. Selecting output with at least one of the chosen search terms, the team used specialized software to organize output by relevance and relationship.

What’s interesting about plant-based molecules potentially capable of stopping what’s known as cysteine proteases?
It turns out that SARS-CoV-2 thrives thanks to an enzyme called 3CLpro, responsible for the processing of proteins essential for the novel coronaviruses thriving. Hence why, drugs such as Paxlovid fall in the class of 3CLpro inhibition.

Other inhibitors involving both PLpro and 3CLpro identified by the researchers include chalcones, especially chalcone 6 as well. Some properties associated with plans inhibit PLpro with more effectiveness—such as polyphenol compounds taken from the leaves of the paper mulberry tree native to eastern Asia.

Overall, the team reported in their paper published in MDPI that of the compounds studied, Papyriflavonol A shows superior ability to inhibit PLpro enzyme. While one compound could inhibit both the relevant proteins—PLpro and 3CLpro: Salvia miltiorrhiza Bunge-derived lipophilic tanshinones.

The researchers analyze the plant-based metabolites’ potential for contributing to regimen targeting SARS-CoV-2, including several other examples.

What’s a takeaway?

The scientific literature suggests a definite therapeutic value associated with certain plant extracts, including ones involved in TCM, targeting SARS-CoV-2, the virus behind COVID-19. The Portuguese researchers document a particular interest in bioactive molecules such as alkaloid compounds as well as phenolic substances from chalcones and flavonoids to tannins and lignins to glycosides.

Likely, with targeted focus and investment in this plant-based medicinal approach, companies focusing on this area could offer substantially safe and effective, not to mention economical treatments against COVID-19. But would this fit into the biopharmaceutical business model?

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Thursday, February 09, 2023


CDC Retrospective Cohort Study: Janssen COVID-19 Vaccines Increases Risk of Guillain–Barré syndrome

Mounting evidence suggests that the COVID-19 vaccines can, on rare occasions, lead to a rare autoimmune condition associated with Guillain–Barré syndrome (GBS). Associated with muscle weakness, this typically virus-originated disease can lead to paralysis, and even death in a minority of cases. GBS has been associated with other vaccines, but it is typically a rare occurrence, and the public benefit of vaccines according to health authorities such as the Center for Disease Control and Prevention (CDC) outweigh rare risks such as GBS.

Recently, physician-scientists affiliated with both the CDC and the Food and Drug Administration (FDA) analyzed in a retrospective cohort study whether COVID-19 vaccines, including Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273), and Johnson & Johnson/Janssen (Ad26.COV2.S) associated with GBS in the period of 21 or 42 days post the vaccination. Tapping into and analyzing data associated with the CDC’s Vaccine Adverse Event Reporting System (VAERS), the investigators analyzed and verified cases of GBS after the COVID-19 jab in Americans aged 18 and above. The CDC and FDA team have gone on the record with this study result that the Janssen COVID-19 vaccine (Ad26.COV2.S) associates with an increased risk of Guillain-Barré syndrome.

Importantly, the study authors report that based on this observational study, there is no association between mRNA COVID-19 vaccination and GBS. The investigators do acknowledge that VAERS is subject to underreporting.

The Condition

With rapid-onset muscle weakness triggered by the immune system damaging the peripheral nervous system, Guillain–Barré Syndrome most often impacts both sides of the body. Typically starting with changes in sensation or pain often in the back along with muscle weakness, it can also start in the hands and feet and spread up the arms or upper body. These symptoms can last for hours or even weeks and during an acute phase, the disease can lead to hospitalization and death. About 15% of acute cases involve a debilitation of breathing muscles leading to the need for mechanical ventilation. The condition may lead to potentially deadly abnormalities associated with heart rate and blood pressure.

GBS occurs throughout the world with a median annual incidence of 1.3 cases per population of 100 000, with men being more frequently affected than women. GBS is considered to be an autoimmune disease triggered by a preceding bacterial or viral infection. About 3,000 to 6,000 cases are diagnosed annually in America.

Study Data

This retrospective cohort study was conducted using US VAERS reports submitted during December 2020 to January 2022. GBS case reports verified as meeting the Brighton Collaboration case definition for GBS in US adults after COVID-19 vaccination were included.

Represented by corresponding author Winston E. Abara, CDC, the study team reported in JAMA that they found a total of 295 validated GBS reports post the COVID-19 jab. What was the average age of individuals afflicted with GBS post the vaccination? Average age was 59 years, and males represented 57.3% of the study subjects.

Out of all the injured, 275 representing 93.2% of the total were hospitalized, while 209 of the incidents happened within 21 days of the subject receiving the COVID-19 vaccine. Another 253 of the safety incidents occurred within 42 days post the COVID-19 vaccine jab.

GBS was more frequently reported within 21 days after Ad26.COV2.S than after BNT162b2 (RRR = 11.40; 95% CI, 8.11-15.99) or mRNA-1273 (RRR = 9.26; 95% CI, 6.57-13.07) vaccination.

The CDC and FDA team have gone on the record with the study results that the Janssen COVID-19 vaccine (Ad26.COV2.S) associates with an increased risk of Guillain-Barré syndrome.

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Bivalent COVID Vaccines Perform Worse Against Variant Now Dominant in United States

The new COVID-19 vaccines don’t work as well against XBB.1.5, the virus variant that’s now dominant in the United States, according to multiple studies.

In one of the papers, researchers found the vaccines boosted neutralizing antibodies, believed to be a measure of protection, but that the antibody levels declined to previous levels within three months.

Compared to the antibody responses to BA.5, the responses to XBB.1.5 were reduced 20-fold.

“Following bivalent mRNA boosting, responses to XBB.1.5 increase but remain low and wane within 3 months back to pre-boost levels. These data suggest that once a year boosters with the current mRNA vaccines may not provide adequate protection for an entire year for those at high risk of complications of COVID-19,” Dr. Dan Barouch, director of the Center for Virology and Vaccine Research at the Beth Israel Deaconess Medical Center and a co-author of the preprint study (pdf), told The Epoch Times via email.

The Moderna and Pfizer vaccines both utilize messenger RNA, or mRNA, technology. The updated versions of the vaccines are bivalent, targeting the Wuhan variant and a sublineage of the BA.4 and BA.5 strain. The new versions were cleared as boosters in the fall of 2022 despite no clinical data being available. They are poised to replace the original vaccines.

Other studies have also found that the bivalents induce a better response than the old, monovalent boosters, but that the response is reduced against XBB.1.5 or its parent, XBB, which comes from BA.2 lineages.

Researchers with Pfizer and Pfizer partners, for instance, reported recently that the antibody levels were the lowest against XBB.1.5, and were particularly low among people without evidence of prior infection. Similarly, researchers with the U.S. National Institutes of Health and other institutions concluded (pdf) that “the lowest titers were observed against XBB.1” and researchers with the U.S. Centers for Disease Control and Prevention (CDC) detected (pdf) “low activity” against XBB.1. And Japanese scientists also observed a reduction in neutralizing power.

A group of Chinese researchers, who reported evidence that XBB.1.5 can more easily evade protection, said that the circulation of the strain “needs to be closely monitored, and the development of effective neutralizing antibodies and vaccines against XBB.1.5 is urgently needed.”

“Based on its genetic characteristics and growth rate estimates, XBB.1.5 is likely to contribute to increases in case incidence globally. There is moderate-strength evidence for increased risk of transmission and immune escape. From reports by several countries, no early signals of increases in severity have been observed,” the World Health Organization stated in a risk assessment (pdf), though it acknowledged that the low number of cases caused by the strain does not enable a confident assessment of severity.

New York officials claimed in January that XBB.1.5 “may be more likely to infect people who have been vaccinated or already had COVID-19,” later adding that they meant compared to prior variants. When asked for evidence to back up the claim, a spokesperson declined to provide any.

Authorization Revoked as XBB Becomes Dominant
Regulators have not yet altered authorizations or approvals for vaccines, but the U.S. Food and Drug Administration (FDA) yanked authorization for Evusheld, a monoclonal antibody treatment, because it said the drug wouldn’t work against XBB.1.5 and other emerging subvariants.

XBB.1.5, an Omicron subvariant like BA.5, was estimated to be behind 66.4 percent of the COVID-19 cases in the United States in the week ending Feb. 4, according to genomic sequencing and other data.

BA.5 was the dominant strain until late 2022, when it was displaced by BQ.1.1 and BQ.1. Those Omicron subvariants make up about a quarter of the cases.

The bivalent vaccines were cleared in part because the vaccines had been performing increasingly worse against Omicron and its subvariants. Regulators chose not to wait for clinical data despite widespread warnings that authorizing the shots without the data would further undermine confidence in the COVID-19 vaccines.

The FDA met with its advisory panel in January but none of the vaccine makers that made presentations during the meeting, including Pfizer and Moderna, presented clinical efficacy data. Officials from the companies alleged that testing data indicated the vaccines work against XBB.

CDC Data

CDC researchers, drawing from testing data, estimated similar vaccine effectiveness (VE) against XBB and BA.5.

For people aged 18 to 49, for instance, the relative effectiveness against symptomatic infection was estimated at 52 percent two to three months after a bivalent booster against the latter and 48 percent against the former.

Relative effectiveness means effectiveness beyond the initial shots, which provide little protection against symptomatic infection.

“‘Generally, VE against symptomatic infection is similar for the two sub lineages and across age groups,” Dr. Ruth Link-Gelles, a CDC researcher and co-author of the report, told the FDA’s advisory panel.

“We’re continuing to monitor this as XBB.1.5 continues to increase nationally,” she added.

Researchers drew from the Increasing Community Access to Testing program, which provides free COVID-19 testing at CBS, Walmart, and other places.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Wednesday, February 08, 2023


California ‘Quietly’ Drops Student COVID-19 Vaccine Mandate

While California’s government is celebrated by some for its commitment to contain and combat COVID-19, many critics have suggested the various governmental and public units, from state offices to universities and school districts, went too far during the COVID-19 response, representing an overreach of constitutional norms and mores. While Gavin Newsom, the Governor of the state, announced a universal COVID-19 vaccination policy by October 2021 (it would eventually apply to 6.7 million public and private school children), the Golden State became one of the first states where school districts proactively pushed universal COVID-19 mandates for children as soon as the Pfizer-BioNTech mRNA vaccine BNT162b2 was formally approved (albeit there was nothing usual about how the controversial vaccine was approved).

Now with the science clearly pointing to the reality that the COVID-19 mRNA vaccines are not only non-sterilizing but also lack breadth in response to various mutations and durability, the Los Angeles Times and other media report that the state has quietly dropped the student COVID-19 vaccine mandate as the state emergency is planned to end February 28. The national public health emergency is scheduled to end by May 11.

Apparently, the mandate was put on hold in April 2022 by the Governor, as was a bill that was to eliminate any exemptions for personal beliefs, writes Howard Blume for the Los Angeles Times.

A confluence of forces converges to make such mandates not even practical anymore, admits the mainstream media.

Most notable is the fact, writes Blume, that SARS-CoV-2 “has evolved to a less deadly, more manageable, and treatable stage. Although COVID-19 remains widespread — and people continue to die from it — the availability of vaccines and antiviral treatments has lessened the effects — offering relief to what had been an overwhelmed public health system.”

In California, Newsom plans to end the state of emergency on Feb. 28, ending a three-year period of history for the Golden State.

It's still taboo to express any critical views of the COVID-19 vaccine products in the mainstream press. On the topic of these products, Blume and contributing writers Adam Beam and Times staff writer Taryn Luna reassure the reader that the move to cease any mandates doesn’t mean that the state rejects the COVID-19 vaccines. In fact, the state’s health department declared:

“COVID-19 immunization is an important tool for keeping our kids healthy and schools open,” the department statement said. “Health officials strongly recommend immunization of students and staff against COVID-19 to prevent hospitalization and other serious complications, including death. Widespread vaccination has contributed to keeping California children in school to learn and to strengthen social connections. Turnkey mobile vaccination services remain available for any K-12 school within the state.”

The Reality

The truth is that the current COVID-19 vaccines, softening the sharp, deadly edges of the COVID-19 pandemic, most definitely exhibited attributes of early state or “Version 1.0” products.

Because the world found out the COVID-19 vaccines were not preventing the contagion from spreading, a movement grew against inoculation mandates by the spring of 2021. It didn’t make much sense if the products didn’t halt the infection in the first place and, thereby stop the transmission of the virus.

That aside, the positioning for the benefits shifted at the time to a reduction in the probability of serious infection and hospitalization, even death. In fact, across many different real-world studies evaluated by TrialSite over the past couple of years, the evidence suggests that the COVID-19 vaccines did serve to induce surges of immune protection during surges of the pandemic, slowing down hospitalization and saving lives.

But two other elements further weakened the prospect of these COVID-19 vaccine products as permanent fixtures on the vaccination schedule in addition to the fact that they were not sterilizing in impact. First, is their lack of breadth, in that as the SARS-CoV-2 virus mutated from Delta into Omicron and various subvariants, increasingly, the pathogen evaded the vaccine’s neutralizing impact, while also and in relation to a mutating RNA virus the durability of the vaccine was questionable. This is why boosters were required, and since the release of the first COVID-19 vaccines to the market in mid-December 2020, up to five doses have been administered, two in the primary series and up to three boosters including the most recent bivalent Omicron BA.4/BA.5 booster does.

The market has resoundingly rejected this product despite intense and ongoing promotional edicts from the government, echoed by health systems. As of this writing, only about 15% of all persons eligible have opted to take the shot.

The whole strategy in response to COVID-19 should be evaluated carefully. For example, early treatment (now emphasized once pharmaceutical products were approved) was de-emphasized when front-line providers produced various approaches in the clinics during the pandemic.

One such approach was the ICAM protocol, which was purportedly saving hundreds of lives out of one Florida-based health system. Involving the use of blood thinners and certain steroids, (both later shown to help) TrialSite learned that once the CEO became aware of the protocol it was canceled. TrialSite brought significant attention to the effort worldwide. Sources conveyed that a contract between Pfizer and the health system precluded the latter from its employees developing any regimen for SARS-CoV-2, even though it was in the middle of a deadly pandemic.

Assuming these declarations are authentic, Pfizer leveraged its position in the pandemic quite ruthlessly to lock in behaviors it deemed appropriate. The message to health systems: If you want access to the COVID-19 vaccines via clinical trials, sign this adhesion-style contract. Of course, there is evidence that Pfizer enforced this approach worldwide via all sorts of unorthodox contracts with draconian clauses. See “Pfizer’s Power in the COVID-19 Vaccine Space.”

Moving forward, state agencies, school districts, and other units of government will likely back out of any hardline COVID-19 vaccine stances now, including relevant mandates, as the science irrefutably reveals the limitations of the current batch of COVID-19 vaccines.

Importantly, this is not to minimize intention for and even the protective results, albeit short-lived, at the time, and in many cases, their influence as a medical tool, along with other approaches during the pandemic, only expresses what the reality is on the ground.

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Study finds way to help children overcome peanut allergy

This is rather old hat. Systematic desensitization has been known to psychologists for decades and its application to peanut allergy also goes back at least a decade. Good that someone is still working on it though

Consuming small, sequential doses of boiled peanuts help overcome children’s allergic reactions, according to a new study.

The research, published in the journal Clinical & Experimental Allergy, found that 80 per cent of children with peanut allergy become desensitised to eating peanuts following the trial.

Since up to three per cent of children in Western countries are grappling with peanut allergies, scientists, including those from Flinders University in the US, say the new clinical trial can help develop a novel treatment to reduce the risk of accidental peanut exposure and improve quality of life for peanut-allergic children.

Their new study is based on previous findings that heat affects the protein structure and allergic properties of peanuts, making them potentially less likely to cause severe allergic reactions.

Scientists tested whether a therapy delivering small, increasing doses of boiled peanuts, followed by roasted peanuts, may help children overcome their peanut allergies.

“Small and increasing doses of boiled nuts were first given to children to partially desensitise them, and when they showed no signs of an allergic reaction, increasing doses of roasted peanuts were then provided to increase their tolerance in the next stage of treatment,” study co-author Tim Chataway said in a statement.

Researchers asked 70 peanut-allergic children of ages six to 18 to consume peanuts boiled for 12 hours for 12 weeks, 2 hour boiled peanuts for 20 weeks, and roasted peanuts for 20 weeks.

Scientists found that 56 of the 70 (80 per cent) participants became desensitized to a daily target dose of consuming 12 roasted peanuts without allergic reactions.

While treatment-related adverse events were reported in over 60 per cent of the participants, only 3 withdrew from the trial as a result, the study noted.

“Our clinical trial shows promising early signs in demonstrating that boiling peanuts may provide a safe and effective method for treating peanut-allergic children with sequential doses of boiled and roasted peanuts over an extended period of time,” says Luke Grzeskowiak, another author of the study, said.

However, scientists caution that this method of therapy may not work for everyone, but add that they are in the process of better understanding what factors can influence how people respond to treatment.

While these findings hold “great promise”, researchers add that the results also require confirmation in a larger definitive clinical trial.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Tuesday, February 07, 2023



Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

There is an old, old fallacy here. Sure: Healthy people survived Covid better but why was that? Was a healthy lifestyle the crucial factor? This article cannot tell us that. It could well be that people who adopted a heathier lifestyle were healthier to start with. And the converse -- that sickly people are unable to adopt many aspects of a healthy lifestyle (such as vigorous exercise) -- is undoubtedly true. So was it lifestyle that protected from Covid in the study below? Maybe, maybe not

It doesn't prove anything by itself but I have a very unhealthy lifestyle and Covid has not touched me at all -- and I am 79, in a high-risk group. So the report below will not influence anything I do


Siwen Wang et al.

Question Is a healthy lifestyle (healthy body mass index, never smoking, high-quality diet, moderate alcohol intake, regular exercise, and adequate sleep) prior to SARS-CoV-2 infection protective of post–COVID-19 condition (PCC)?

Findings In this prospective cohort study of 1981 women who reported a positive SARS-CoV-2 test from April 2020 to November 2021, adherence to a healthy lifestyle prior to infection was inversely associated with risk of PCC in a dose-dependent manner. Compared with those who did not have any healthy lifestyle factors, those with 5 or 6 had half the risk of PCC.

Meaning Preinfection healthy lifestyle was associated with a substantially decreased risk of PCC.

Abstract

Importance Few modifiable risk factors for post–COVID-19 condition (PCC) have been identified.

Objective To investigate the association between healthy lifestyle factors prior to SARS-CoV-2 infection and risk of PCC.

Design, Setting, and Participants In this prospective cohort study, 32 249 women in the Nurses’ Health Study II cohort reported preinfection lifestyle habits in 2015 and 2017. Healthy lifestyle factors included healthy body mass index (BMI, 18.5-24.9; calculated as weight in kilograms divided by height in meters squared), never smoking, at least 150 minutes per week of moderate to vigorous physical activity, moderate alcohol intake (5 to 15 g/d), high diet quality (upper 40% of Alternate Healthy Eating Index–2010 score), and adequate sleep (7 to 9 h/d).

Main Outcomes and Measures SARS-CoV-2 infection (confirmed by test) and PCC (at least 4 weeks of symptoms) were self-reported on 7 periodic surveys administered from April 2020 to November 2021. Among participants with SARS-CoV-2 infection, the relative risk (RR) of PCC in association with the number of healthy lifestyle factors (0 to 6) was estimated using Poisson regression and adjusting for demographic factors and comorbidities.

Results A total of 1981 women with a positive SARS-CoV-2 test over 19 months of follow-up were documented. Among those participants, mean age was 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) were White; and 42.8% (n = 848) were active health care workers. Among these, 871 (44.0%) developed PCC. Healthy lifestyle was associated with lower risk of PCC in a dose-dependent manner. Compared with women without any healthy lifestyle factors, those with 5 to 6 had 49% lower risk (RR, 0.51; 95% CI, 0.33-0.78) of PCC. In a model mutually adjusted for all lifestyle factors, BMI and sleep were independently associated with risk of PCC (BMI, 18.5-24.9 vs others, RR, 0.85; 95% CI, 0.73-1.00, P = .046; sleep, 7-9 h/d vs others, RR, 0.83; 95% CI, 0.72-0.95, P = .008). If these associations were causal, 36.0% of PCC cases would have been prevented if all participants had 5 to 6 healthy lifestyle factors (population attributable risk percentage, 36.0%; 95% CI, 14.1%-52.7%). Results were comparable when PCC was defined as symptoms of at least 2-month duration or having ongoing symptoms at the time of PCC assessment.

Conclusions and Relevance In this prospective cohort study, pre-infection healthy lifestyle was associated with a substantially lower risk of PCC. Future research should investigate whether lifestyle interventions may reduce risk of developing PCC or mitigate symptoms among individuals with PCC or possibly other postinfection syndromes.

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Do mask mandates work?

This week there was an update to a Cochrane review, which studies the way physical interventions can interrupt or reduce the spread of respiratory viruses. The review, which Tom Jefferson is the lead author of, looks at evidence from 78 randomised trials with over 610,000 participants. In other words, this review is exactly the sort of higher-quality evidence you want when making healthcare decisions.

The review’s fifth update looked at handwashing, antiseptic use, social distancing and barriers such as masks, gloves, gowns and visors.

Given past controversies, it’s worth looking at what the review says about the effects medical or surgical masks have on the way respiratory diseases spread.

Interestingly, 12 trials in the review, ten in the community and two among healthcare workers, found that wearing masks in the community probably makes little or no difference to influenza-like or Covid-19-like illness transmission. Equally, the review found that masks had no effect on laboratory-confirmed influenza or SARS-CoV-2 outcomes. Five other trials showed no difference between one type of mask over another.

This is the second update of the review since the start of the pandemic. The first update was delayed by seven months due to unexplained editorial decisions. It was too late when it came out in November 2020 to make a difference to national Covid policy; by then, activism, low-quality observational evidence and government policy had set the agenda for mask mandates, and the damage had been done.

Often these government policies relied on observational studies on mask usage and the spread of Covid. But there are lots of flaws in observational evidence. For example, in the absence of a study protocol setting out methods before the study is done, it is possible to shift the dates of an observational analysis to suit the rise and fall in infections. So if you time your analysis near the peak of infections, the results will favour mask interventions as the infection rate quickly decreases.

But when we pointed out in November 2020 the troubling lack of robust evidence on face masks and the problems with observational studies, we were shouted down, removed from Facebook and put on the government’s secret watchlist.

What many also failed to notice at the time was that studies that look at individuals – as opposed to populations – can lead to erroneous policy decisions. Studies which involve individuals frequently track people who have specifically chosen to wear a mask. But policies on mandatory masks are very different – they involve lots of people who don’t like wearing masks every day, and many people who won’t wear one at all. A study which only looks at keen mask-wearers will not reflect how people comply on a population level.

The Cochrane review findings report relatively low adherence to mask-wearing, which is similar to what happens in the real world. With better adherence and higher quality masks (and if you are careful when you step out the door), you might reduce your risk in specific settings by a small amount. However, when you scale up any potential small benefits to those who step out the door regularly, the effect doesn’t stack up as a population-based intervention.

Mandates that affected the whole population never made sense. Moreover, even in high adherence populations such as Japan, they have not stemmed an inevitable rise in infections. Part of the problem may be that during the pandemic the government had to be seen to be doing something. Interventions like handwashing and vaccines are invisible, but masks acted as a visible sign of compliance.

What we have witnessed in this pandemic are strong beliefs about what works and what doesn’t. At times, it’s been more like a football match, with cheerleaders on either side goading the opposition. Several policies such as mask mandates, restrictions, and unproven interventions now seem absurd in hindsight. And as the culture of fear has lifted, the population has become all too aware of their detrimental effects.

We failed to follow an evidence-based approach during the pandemic. We are now left with the human, social and economic aftermath of evidence-free policies.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Monday, February 06, 2023



Vitamin D and Covid



Journal article:

Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

Christiano Argano et al.

Abstract

Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin D plays a crucial role in immune function and inflammation. Recent data have suggested a protective role of vitamin D in COVID-19-related health outcomes. The purpose of this meta-analysis and trial sequential analysis (TSA) was to better explain the strength of the association between the protective role of vitamin D supplementation and the risk of mortality and admission to intensive care units (ICUs) in patients with COVID-19.

Methods: We searched four databases on 20 September 2022. Two reviewers screened the randomized clinical trials (RCTs) and assessed the risk of bias, independently and in duplicate. The pre-specified outcomes of interest were mortality and ICU admission.

Results: We identified 78 bibliographic citations. After the reviewers’ screening, only five RCTs were found to be suitable for our analysis. We performed meta-analyses and then TSAs. Vitamin D administration results in a decreased risk of death and ICU admission (standardized mean difference (95% CI): 0.49 (0.34–0.72) and 0.28 (0.20–0.39), respectively). The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive. The TSA of the protective role of vitamin D in mortality risk showed that the z-curve was inside the alpha boundaries, indicating that the positive results need further studies.

Discussion: The results of the meta-analyses and respective TSAs suggest a definitive association between the protective role of vitamin D and ICU hospitalization.

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Look back in anger at government Covid folly

Remember this joke: a teenager kills his parents and appeals to the courts for mercy as an orphan? The Australian Medical Association backed lockdown restrictions back in the day but is now complaining about the growing backlog in elective surgery. Here’s a question. Had the vast sums thrown at Covid been redirected to the leading killer diseases, using the standard quality-adjusted life year metric, how many million deaths would have been averted around the world over the next decade? The lockdown harms are showing up in excess death counts, job losses, supply chain chaos, rising cost of living, and have locked in generational poverty and inequality in and across nations. Historical illiteracy is now a job requirement for ‘experts’. Germany has burnt 17.25 million masks past their expiry date, while stockpiling more for future emergencies. Recalling Margaret Thatcher’s comment on the trouble with socialism, politicians don’t learn from mistakes made with other people’s money. The media too lived down to their description as stenographers with amnesia. The state dictated every aspect of peoples’ lives, down to the most ridiculous, absurd and intimate details. With no known cure for blind faith in governments, people embraced compliance with draconian directives from politicians proffering iron fists as a magic bullet.

Lockdowns were a euphemism for a wholesale shutting down of social and economic activities and putting entire populations under house arrest. Neither based in science and best-practice medicine, nor commensurate with the age-stratified threat from the virus, they lasted on and off for two years with constantly shifting goalposts. As early as February-March 2020, data told us that elderly people with comorbidities were the most vulnerable. In a modern-day version of sacrificing virgins to appease the viral gods, the young have lost many more years of their life to buy a few more lonely, miserable months for the infirm old. A study in the Proceedings of the National Academy of Sciences showed that lack of household exposure to kids increased Covid hospitalisation of grown-ups by 27 per cent and ICU admission by 49 per cent. They should have said: ‘Don’t be a Granny killer. Leave that to us.’

The UK Influenza Preparedness Strategy 2011 encapsulated the prevailing consensus on masks: ‘there is very little evidence of widespread benefit from their use in [the community and household] setting’. The lack of observed differences can be seen in a series of comparative charts in Ian Miller’s Unmasked: The Global Failure of Covid Mask Mandates (2022). Governments ‘nudged’ the public to exert peer pressure as a tool of social coercion, backed by sometimes brutal police action against pockets of resistance and protest. Mask mandates reflected and perpetuated the reign of fear and demonstrated broad compliance with the effort of governments to exercise population-wide social control. A highly visible symbol of collectivist compliance, masks became Mao suits for the face. The degree of coercion deployed to increase vaccine uptake would not have been possible without the ground having first been prepared with lockdowns and masks.

Japan has extraordinarily high levels of public compliance with government directives and mask wearing is all pervasive. Using Our World in Data figures, Japan hit 80 per cent full vaccination on 9 December 2021 when its Covid daily death rate was 0.01 per million. This had risen to 3.43 per million on 9 January 2023. Total deaths had increased from 18,370 to 63,777 over that period. Thus 2.5 times as many people died with Covid in the 13.5 months after full vaccination than in the 21.3 months before 80 per cent full vaccination. Yet they still refuse to entertain the notion that vaccines might be the problem, not the solution. The continued hold of the ‘safe and effective’ vaccine mantra, and face mask efficacy for controlling the coronavirus is cause for despair in official cussedness and public gullibility. The transient effectiveness of vaccines has necessitated boosters every few months. Often vaccine rollouts coincided with upsurges in infections and deaths, suggesting negative efficacy. Newer studies show successive doses are less effective and repeated doses may be driving infections by damaging immune function. When vaccines began to be administered at the end of 2020, 1.9 million people had died with Covid globally. Another 4.8 million have died since then. Added to the growing toll of vaccine injuries, this has discredited officials and experts who claimed the vaccines would prevent infection, transmission, severe illness and death. Yet all that matters to zealots is how many arms are jabbed and how often.

With help from the media, social media (thank you, Elon Musk, for the Twitter Files) and police, people were frightened, shamed and brutalised into submission to arbitrary and authoritarian diktats. Governments deployed state propaganda to instil fear of the disease and shame all effort to question edicts. Turning the debate from a scientific discourse into a moral imperative facilitated the demonisation and denigration of critical voices on the lethality of the virus, the effectiveness and ethics of lockdowns, masks and vaccine mandates, and the harms inflicted by these interventions. Calls have grown for an immediate suspension of vaccinations until the unusually strong correlation with excess deaths, heart problems and female reproduction are properly investigated. Instead, suspicions become only stronger that regulators have become vaccine-enablers first, more committed to defend vaccines from criticism than protect people from harmful vaccines. The media switched from exposing official lies to amplifying them. One dispiriting lesson of the last three years is people will ‘live happily ever after’ as long as the media ignores how governments trample our freedoms while claiming to keep us safe.

On every major point of contention in managing the pandemic, the Great Barrington Declaration was right. Fearmongers-in-chief like Neil Ferguson, Anthony Fauci (whose omniscience deserted him during deposition) and their local ‘useful idiots’ were wrong. The common sense distilled into the few words of the Declaration was an uncommon virtue. The three scientist-authors – from Harvard, Oxford and Stanford! – were taken down savagely and belittled as ‘fringe epidemiologists’. This malfeasance was compounded by the cowardice of political leaders hiding behind ‘Follow the Science’ that mistook a slogan for policy and let loose upon democratic societies previously unimaginable acts and scenes of censorship, coercion and brutality which have gradually eroded trust in authorities and institutions. Recovery and healing will be difficult without accountability, punishment and robust institutional guardrails against repeating episodes of the abuses.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Sunday, February 05, 2023



Inside the Secret Government Meeting on COVID-19 Natural Immunity

Natural immunity downplayed. EVERYONE should be vaccinated

Four of the highest ranking U.S. health officials—including Dr. Anthony Fauci—met in secret to discuss whether or not naturally immune people should be exempt from getting COVID-19 vaccines, The Epoch Times can reveal.

The officials brought in four outside experts to discuss whether the protection gained after recovering from COVID-19—known as natural immunity—should count as one or more vaccine doses.

“There was interest in several people in the administration in hearing basically the opinions of four immunologists in terms of what we thought about … natural infection as contributing to protection against moderate to severe disease, and to what extent that should influence dosing,” Dr. Paul Offit, one of the experts, told The Epoch Times.

Offit and another expert took the position that the naturally immune need fewer doses. The other two experts argued natural immunity shouldn’t count as anything.

The discussion did not lead to a change in U.S. vaccination policy, which has never acknowledged post-infection protection. Fauci and the other U.S. officials who heard from the experts have repeatedly downplayed that protection, claiming that it is inferior to vaccine-bestowed immunity. Most studies on the subject indicate the opposite.

The meeting, held in October 2021, was briefly discussed before on a podcast. The Epoch Times has independently confirmed the meeting took place, identified all of the participants, and uncovered other key details.

Dr. Jay Bhattacharya, a professor of medicine at Stanford University who did not participate in the meeting, criticized how such a consequential discussion took place behind closed doors with only a few people present.

“It was a really impactful decision that they made in private with a very small number of people involved. And they reached the wrong decision,” Bhattacharya told The Epoch Times:

Fauci and Murthy decided to hold the meeting, according to emails The Epoch Times obtained.

“Would you be available tonight from 9-9:30 for a call with a few other scientific colleagues on infection-induced immunity? Tony and I just discussed and were hoping to do this sooner rather than later if possible,” Murthy wrote in one missive to Fauci, Walensky, and Collins.

All three quickly said they could make it.

Walensky asked who would be there.

Murthy listed the participants. “I think you know all of them right?” he said. Walensky said she knew all but one person. “Sounds like a good crew,” she added.

During the meeting, Offit put forth his position—that natural immunity should count as two doses.

At the time, the CDC recommended three shots—a two-dose primary series and a booster—for many Americans 18 and older, soon expanding that advice to all adults, even though trials of the boosters only analyzed immunogenicity and efficacy among those without evidence of prior infection.

Research indicated that natural immunity was long-lasting and superior to vaccination. On the other hand, the CDC published a paper in its quasi-journal that concluded vaccination was better.

Osterholm sided with Offit, but thought that having recovered from COVID-19 should only count as a single dose.

“I added my voice at the meeting to count an infection as equivalent to a dose of vaccine! I’ve always believed hybrid immunity likely provides the most protection,” Osterholm told The Epoch Times via email.

Hybrid immunity refers to getting a vaccine after recovering from COVID-19.

Some papers have found vaccination after recovery boosts antibodies, which are believed to be a correlate of protection. Other research has shown that the naturally immune have a higher risk of side effects than those who haven’t recovered from infection. Some experts believe the risk is worth the benefit but others do not.

Hotez and Iwasaki, meanwhile, made the case that natural immunity should not count as any dose—as has been the case in virtually the entire United States since the COVID-19 vaccines were first rolled out.

Iwasaki referred to a British preprint study, soon after published in Nature, that concluded, based on survey data, that the protection from the Pfizer and AstraZeneca vaccines was heightened among people with evidence of prior infection.

She also noted a study she worked on that found the naturally immune had higher antibody titers than the vaccinated, but that the vaccinated “reached comparable levels of neutralization responses to the ancestral strain after the second vaccine dose.” The researchers also discovered T cells—thought to protect against severe illness—were boosted by vaccination.

There’s a “clear benefit” to boosting regardless of prior infection, Iwasaki, who has since received more than $2 million in grants from the National Institutes of Health (NIH), told participants after the meeting in an email obtained by The Epoch Times. Hotez received $789,000 in grants from the NIH in fiscal year 2020, and has received other grants totaling millions in previous years. Offit, who co-invented the rotavirus vaccine, received $3.5 million in NIH grants from 1985 through 2004.

Hotez declined interview requests through a spokesperson. Iwasaki did not respond to requests for comment.

No participants represented experts like Bhattacharya who say that the naturally immune generally don’t need any doses at all.

In public, Hotez repeatedly portrayed natural immunity as worse than vaccination, including citing the widely criticized CDC paper, which drew from just two months of testing in a single state.

In one post on Twitter on Oct. 29, 2021, he referred to another CDC study, which concluded that the naturally immune were five times as likely to test positive compared to vaccinated people with no prior infection, and stated: “Still more evidence, this time from @CDCMMWR showing that vaccine-induced immunity is way better than infection and recovery, what some call weirdly ‘natural immunity’. The antivaccine and far right groups go ballistic, but it’s the reality.”

That same day, the CDC issued a “science brief” that detailed the agency’s position on natural immunity versus the protection from vaccines. The brief, which has never been updated, says that available evidence shows both the vaccinated and naturally immune “have a low risk of subsequent infection for at least 6 months” but that “the body of evidence for infection-induced immunity is more limited than that for vaccine-induced immunity.”

Evidence shows that vaccination after infection, or hybrid immunity, “significantly enhances protection and further reduces risk of reinfection” and is the foundation of the CDC’s recommendations, the agency said.

Several months later, the CDC acknowledged that natural immunity was superior to vaccination against the Delta variant, which was displaced in late 2021 by Omicron. The CDC, which has made misleading representations before on the evidence supporting vaccination of the naturally immune, did not respond to a request for comment regarding whether the agency will ever update the brief.

Iwasaki had initially been open to curbing the number of doses for the naturally immune—”I think this supports the idea of just giving one dose to people who had covid19,” she said in response to one Twitter post in early 2021, which is restricted from view—but later came to argue that each person who is infected has a different immune response, and that the natural immunity, even if strong initially, wanes over time.

Osterholm has knocked people who claim natural immunity is weak or non-existent, but has also claimed that vaccine-bestowed immunity is better. Osterholm also changed the stance he took in the meeting just several months later, saying in February 2022 that “we’ve got to make three doses the actual standard” while also “trying to understand what kind of immunity we get from a previous infection.”

Offit has been the leading critic on the Vaccines and Related Biological Products Advisory Committee, which advises U.S. regulators on vaccines, over their authorizations of COVID-19 boosters. Offit has said boosters are unnecessary for the young and healthy because they don’t add much to the primary series. He also criticized regulators for authorizing updated shots without consulting the committee and absent clinical data. Two of the top U.S. Food and Drug Administration (FDA) officials resigned over the booster push. No FDA officials were listed on invitations to the secret meeting on natural immunity.

Fauci and Walensky, two of the most visible U.S. health officials during the pandemic, have repeatedly downplayed natural immunity.

Fauci, who said in an email in March 2020 that he assumed there would be “substantial immunity post infection,” would say later that natural immunity was real but that the durability was uncertain. He noted the studies finding higher antibody levels from hybrid immunity.

In September 2021, months after claiming that vaccinated people “can feel safe that they are not going to get infected,” Fauci said that he did not have “a really firm answer” on whether the naturally immune should get vaccinated.

“It is conceivable that you got infected, you’re protected—but you may not be protected for an indefinite period of time,” Fauci said on CNN when pressed on the issue. “So I think that is something that we need to sit down and discuss seriously.”

After the meeting, Fauci would say that natural immunity and vaccine-bestowed immunity both wane, and that people should get vaccinated regardless of prior infection to boost their protection.

Walensky, before she became CDC director, signed a document called the John Snow Memorandum in response to the Great Barrington Declaration, which Bhattacharya coauthored. The declaration called for focused protection of the elderly and otherwise infirm, stating, “The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk.”

The memorandum, in contrast, said there was “no evidence for lasting protective immunity to SARS-CoV-2 following natural infection” and supported the harsh lockdown measures that had been imposed in the United States and elsewhere.

In March 2021, after becoming director, Walensky released recommendations that the naturally immune get vaccinated, noting that there was “substantial durability” of protection six months after infection but that “rare cases of reinfection” had been reported.

Walensky hyped the CDC study on natural immunity in August 2021, and the second study in October 2021. But when the third paper came out concluding natural immunity was superior, she did not issue a statement. Walensky later told a blog that the study found natural immunity provided strong protection, “perhaps even more so than those who had been vaccinated and not yet boosted.”

But, because it came before Omicron, she said, “it’s not entirely clear how that protection works in the context of Omicron and boosting.”

Walensky, Murthy, and Collins did not respond to requests for interviews. Fauci, who stepped down from his positions in late 2022, could not be reached.

Murthy and Collins also portrayed natural immunity as inferior. “From the studies about natural immunity, we are seeing more and more data that tells us that while you get some protection from natural infection, it’s not nearly as strong as what you get from the vaccine,” Murthy said on CNN about two months before the meeting. Collins, in a series of blog posts, highlighted the studies showing higher antibody levels after vaccination and urged people to get vaccinated. He also voiced support for vaccine mandates.

Some other countries offered the naturally immune benefits.

Just days after U.S. officials heard from the experts, Israel announced that people who presented serological proof of prior infection could get a “green pass,” which was required in the country to enter certain venues, for six months. Some European Union countries said the naturally immune only needed a single dose, instead of two, to receive a digital certificate, enabling free movement within the bloc. The United Kingdom’s travel pass was available to people who tested positive for COVID-19 if the test was within the previous 180 days.

But U.S. policy on vaccines, which has been the basis for vaccination mandates across sectors such as education and health care, was not altered at all in the wake of the meeting.

“I think it’s because the opinions were sort of generally diverse, so there wasn’t a clear, unified message that came out of that,” Offit told The Epoch Times, adding via email that there was “generally a divide among participants about how to think about this,” with “no firm conclusions.”

Bhattacharya said that the discussion happened too late, asserting it was already clear in 2020 that natural immunity protected against both severe disease and reinfection.

“The fact that the head of the CDC and the surgeon general both seem to have ignored these basic scientific facts is a scandal,” he said. “And it resulted in countless Americans losing their jobs for nothing.”

In 2022, the CDC did say that people who recovered from COVID-19 could wait up to three months after infection to get vaccinated, stating that reinfection “is less likely in the weeks to months after infection” and that waiting “might result in an improved immune response to vaccination.”

Over time, some other U.S. policies came to acknowledge natural immunity. Walensky in April 2022 (pdf), for instance, when ordering the end of a public health policy called Title 42, said that she was doing so because deaths and hospitalizations in the Omicron era were lower “due, in part, to widespread population immunity.”

A connecting footnote stated, “In addition to vaccine-induced immunity, studies have consistently shown that infection with SARS-CoV-2 lowers an individual’s risk of subsequent infection and an even lower risk of hospitalization and death.” SARS-CoV-2 causes COVID-19.

In August 2022, the CDC eased its COVID-19 guidelines, stating in part that “persons who have had COVID-19 but are not vaccinated have some degree of protection against severe illness from their previous infection.”

And on Jan. 26, the FDA convened Offit and the other advisers on the vaccine advisory committee to consider various vaccine-related issues. Among them? Whether the naturally immune should be advised to only get one shot, even if they’ve never been vaccinated before.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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