Tuesday, August 11, 2020


World’s Top Epidemiologists – Masks Don’t Work!

Denmark boasts one of the lowest COVID-19 death rates in the world. As of August 4, the Danes have suffered 616 COVID-19 deaths, according to figures from Johns Hopkins University.

That’s less than one-third of the number of Danes who die from pneumonia or influenza in a given year.

Despite this success, Danish leaders recently found themselves on the defensive. The reason is that Danes aren’t wearing face masks, and local authorities for the most part aren’t even recommending them.

This prompted Berlingske, the country’s oldest newspaper, to complain that Danes had positioned themselves “to the right of Trump.”

“The whole world is wearing face masks, even Donald Trump,” Berlingske pointed out.

This apparently did not sit well with Danish health officials.  They responded by noting there is little conclusive evidence that face masks are an effective way to limit the spread of respiratory viruses.

“All these countries recommending face masks haven’t made their decisions based on new studies,” said Henning Bundgaard, chief physician at Denmark’s Rigshospitale, according to Bloomberg News.

Denmark is not alone. Despite a global stampede of mask-wearing, data show that 80-90 percent of people in Finland and Holland say they “never” wear masks when they go out, a sharp contrast to the 80-90 percent of people in Spain and Italy who say they “always” wear masks when they go out.

Dutch public health officials recently explained why they’re not recommending masks. “From a medical point of view, there is no evidence of a medical effect of wearing face masks, so we decided not to impose a national obligation,” said Medical Care Minister Tamara van Ark.

Others, echoing statements similar to the US Surgeon General from early March, said masks could make individuals sicker and exacerbate the spread of the virus.

“Face masks in public places are not necessary, based on all the current evidence,” said Coen Berends, spokesman for the National Institute for Public Health and the Environment. “There is no benefit and there may even be negative impact.”

In Sweden, where COVID-19 deaths have slowed to a crawl, public health officials say they see “no point” in requiring individuals to wear masks.

“With numbers diminishing very quickly in Sweden, we see no point in wearing a face mask in Sweden, not even on public transport,” said Anders Tegnell, Sweden’s top infectious disease expert.

For the average person, it’s confusing and frustrating. It’s also a bit frightening, considering that we’ve seen people denounced in public for not wearing a mask while picking up a bag of groceries.

The truth is masks have become the new wedge issue, the latest phase of the culture war. Mask opponents tend to see mask wearers as “fraidy cats” or virtue-signalling “sheeple” who willfully ignore basic science. Mask supporters, on the other hand, often see people who refuse to wear masks as selfish Trumpkins … who willfully ignore basic science.

There’s not a lot of middle ground to be found and there’s no easy way to sit this one out. We all have to go outside, so at some we all are required to don the mask or not.

It’s clear from the data that despite the impression of Americans as selfish rebel cowboys who won’t wear a mask to protect others, Americans are wearing masks far more than many people in European countries.

Polls show Americans are wearing masks at record levels, though a political divide remains: 98 percent of Democrats report wearing masks in public compared to 66 percent of Republicans and 85 percent of Independents. (These numbers, no doubt, are to some extent the product of mask requirements in cities and states.)

Whether one is pro-mask or anti-mask, the fact of the matter is that face coverings have become politicized to an unhealthy degree, which stands to only further pollute the science.

Last month, for example, researchers at Minnesota’s Center for Infectious Disease Research and Policy responded to demands they remove an article that found mask requirements were “not based on sound data.”

The school, to its credit, did not remove the article, but instead opted to address the objections critics of their research had raised.

SOURCE 

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Common colds train the immune system to recognize COVID-19

This existing immune system "memory" may explain why some people have milder COVID-19 infections.

Previous infections with common cold viruses can train the immune system to recognize SARS-CoV-2, the virus that causes COVID-19, according to a new study.

The study, published Aug. 4 in the journal Science, found that immune cells known as T cells that recognize common cold coronaviruses also recognize specific sites on SARS-CoV-2 — including parts of the infamous "spike" protein it uses to bind to and invade human cells.

This existing immune system "memory" may explain why some people have milder COVID-19 infections compared with others; however, the authors stress that this hypothesis is "highly speculative" and requires more research to confirm. That's because it's unknown exactly how big a role T cells play in fighting COVID-19 — T cells are just one part of a complex menagerie of molecules and cells that makes up our immune system.

"We have now proven that, in some people, preexisting T-cell memory against common cold coronaviruses can cross-recognize SARS-CoV-2, down to the exact molecular structures," study co-lead author Daniela Weiskopf, assistant professor at La Jolla Institute for Immunology in La Jolla, California, said in a statement.

It's possible that this "immune reactivity may translate to different degrees of protection" against COVID-19, study co-lead author Alessandro Sette, a professor at La Jolla Institute for Immunology, said in the statement. "Having a strong T-cell response, or a better T-cell response may give you the opportunity to mount a much quicker and stronger response."

Previous studies have shown that upwards of 50% of people never exposed to COVID-19 have T cells that recognize SARS-CoV-2. This ability has been seen in people around the world, in the Netherlands, Germany, the United Kingdom and Singapore. Scientists hypothesized that this existing immunity could be due to previous infections with other coronaviruses, specifically those that cause common cold infections.

In the new study, the researchers analyzed blood samples collected from people between 2015 and 2018, well before COVID-19 first emerged in Wuhan, China.

These blood samples contained T cells that reacted to more than 100 specific sites on SARS-CoV-2. The researchers showed that these T cells also reacted to similar sites on four different coronaviruses that cause common cold infections.

"This study provides very strong direct molecular evidence that memory T cells can 'see' sequences that are very similar between common cold coronaviruses and SARS-CoV-2," Sette said.

In addition to binding to the spike protein, the T cells  also recognized other viral proteins beyond the spike.

Currently, most COVID-19 vaccine candidates target the spike protein, but the new findings suggest that including other proteins in a vaccine, besides the spike, might harness this T cell cross reactivity and potentially enhance the vaccine's potency, the researchers said, although much more research would be needed to show this.

The authors note that their findings of cross-reactivity with T cells are different from what has been seen with neutralizing antibodies — another weapon of the immune system that blocks a pathogen from infecting cells. Neutralizing antibodies against common cold viruses are specific to those viruses and don't show cross-reactivity with SARS-CoV-2, according to previous studies, the authors said.

SOURCE 

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Kudlow Says Another Lockdown Would Have ‘Enormous’ Human and Economic Cost

White House economic adviser Larry Kudlow firmly opposes the idea of a hard lockdown to suppress another COVID-19 surge, telling Fox Business in an Aug. 4 interview that the health and economic toll on Americans would be “enormous.”

Kudlow said he doesn’t think any form of lockdown is a good idea, and people should instead rely on precautions such as social distancing, mask-wearing, and sanitizing to stem the outbreak, while allowing businesses and schools to stay open.

“This idea of more lockdowns, people just throw this out willy-nilly, forgetting the enormous human cost as well as the enormous economic cost,” Kudlow said. “The country can’t take that.”

He argued that the risk to Americans comes not just from the direct threat of infection but from the impact of heavy-handed mitigation.

“It’s also our well-being, it’s also our psychological well-being, it’s our personal well-being,” Kudlow said. “I think we should do everything we can, everything humanly possible, with safety and security, to keep the stores open, to keep the schools open, to keep the economy open.”

Arguing that the current COVID-19 mitigation efforts appear to be working, Kudlow said: “Let’s get America moving again. You’ll get your 20 percent; the V-shaped recovery, I think, is still in place.”

Kudlow’s reference to “20 percent” relates to an earlier comment he made about the Atlanta Fed’s latest estimate of U.S. economic activity for the third quarter of this year. The Atlanta Fed’s third-quarter-growth prediction stands at a seasonally adjusted annualized rate of 19.6 percent, updated on Aug. 3, according to a so-called nowcast statistical model that uses high-frequency economic data-points to estimate the country’s gross domestic product (GDP).

Prompting Kudlow’s remarks was a request by the interviewer for comment on a statement made by a top Federal Reserve official on Aug. 2, who argued that the U.S. economy could benefit if the nation were to “lock down really hard” for 4 to 6 weeks.

“I hate to even suggest it,” said Minneapolis Federal Reserve Bank President Neel Kashkari, in remarks on CBS’s “Face the Nation.”

“People will be frustrated by it. But if we were to lock down hard for a month or six weeks, we could get the case count down so that our testing and our contact tracing was actually enough to control it the way that it’s happening in the Northeast right now,” Kashkari said.

He said the economy, which in the second quarter suffered its biggest blow since the Great Depression, would be able to mount a robust recovery, but only if the virus were brought under control.

“If we don’t do that, and we just have this raging virus spreading throughout the country with flare-ups and local lockdowns for the next year or two, which is entirely possible, we’re going to see many, many more business bankruptcies,” Kashkari said.

“That’s going to be a much slower recovery for all of us.”

Reinforcing Kudlow’s perspective, White House press secretary Kayleigh McEnany told reporters at a briefing on Aug. 4 that the administration wasn’t considering a lockdown.

“The president is not considering a national lockdown,” she said. “What he is encouraging is mitigation efforts like wearing a mask, which is patriotic; like social distancing; and engaging in these really commonsense, safe measures to safely reopen and avoid the health consequences of a lockdown.”

McEnany cited a series of negative outcomes that she linked to lockdowns, including a surge in drug overdoses and suicides.

“Overdoses do go up, suicides do go up, cancer cases are missed, as Dr. Scott Atlas has pointed out that, ‘In the U.S. alone, there are 150,000 new cancer cases that arise every month among patients … most have not been seen.’ And that was referring to the lockdown,” she said.

SOURCE 

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Trump's Covid boast is nearer to the truth than his opponents would like to admit

Given that enlightened opinion now pretty well defines itself against whatever Donald Trump says, it is hardly surprising to hear the US president being excoriated for saying in a television interview that the US figures for deaths per cases of Covid were “lower than the world, lower than Europe”.   

That people laugh at him whenever he opens his mouth on Covid-19 – or anything else for that matter – doesn’t change the fact that technically he is correct. He was clear that he was referring to the ratio of deaths to recorded cases of Covid 19 – a metric technically known as the Case Fatality Ratio (CFR). 

Sure enough, the US currently has a CFR of 0.033 – which is lower than the world as a whole (0.037) and lower than in the larger European countries. Britain’s CFR is currently 0.15, Italy’s 0.14 and Germany’s 0.043.

SOURCE 

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