Monday, August 30, 2021

Israel’s grand vaccine experiment as the world and UK watches on

The only person who kept calm in the packed health clinic in northern Jerusalem on Monday morning was a 19-year-old military medic. As dozens jostled in the narrow corridor leading to the vaccination booths, arguing over whose turn it was next, he surveyed the scene wryly before sitting back in his booth and preparing a syringe with 0.3 millilitres of the Pfizer-BioNTech vaccine which he then plunged into my shoulder.

“This is actually a lull,” he said. “You should have been here an hour ago when the real chaos began.” Perhaps for the soldier — seconded the previous week from his combat engineering battalion on desert manoeuvres — sitting all day in an air-conditioned clinic was an improvement. But no one else there shared his equanimity.

Israel is the first country to embark on a second nationwide vaccination campaign for Covid-19. This time, the jabbing takes place on two fronts. For those over 30, who received their first two jabs at least five months ago, there’s a third “booster” dose. There’s also a push to vaccinate as many secondary pupils (over-12s) as possible before the new school year begins next Wednesday.

But although more than a million and a half Israelis have already had a third jab, the atmosphere is very different from the first roll-out, when huge vaccination centres were opened in sports stadiums and city squares, and many people, overjoyed at the prospect of lockdown lifting, broke into song and started dancing. Now, Covid cases are spiralling again — with the daily rate more than doubling in the past two weeks. Hospitalisations are also rising. “I believe we are at war,” coronavirus commissioner Professor Salman Zarka told a parliamentary committee this month. Israel is pinning its hopes on the booster programme.

It wasn’t supposed to be like this. Back in March, Israel’s vaccination programme was the envy of the world. And vaccines, which proved effective against a third wave of Covid-19 fuelled mainly by the Kent variant, allowed the country to reopen. Joyous Israelis, with the “green pass” vaccine passport on their smartphones, packed out restaurants and bars, and vaccination centres were dismantled. In March, face mask requirements were removed. Then came the Delta variant. Now, Israel finds itself serving as a test case for the longer-term efficacy of a vaccine programme.

Public health experts are not surprised. They had warned that it was impossible to predict whether the new vaccine would give adequate protection against new variants — that the protection would wane over time, perhaps in a matter of months. And that while it would probably continue to give significant protection against serious illness from Covid-19, that didn’t mean those vaccinated couldn’t still become infected and pass the virus on to others.

And that’s exactly what happened in the spring. The first Israelis to get vaccinated in December (unlike in Britain, Israel worked according to the Pfizer protocol, delivering the two doses three weeks apart) were relatively mobile and well-to-do citizens over the age of 60. As the country emerged from lockdown, many flew abroad for holidays. With the vaccine beginning to weaken, some came home infected with the Delta variant. Next, they infected their children and grandchildren, and the highly contagious strain swept through schools in the weeks before the summer holiday.

It didn’t help that around that time, the government changed and ministers took their eyes off the ball. In the spring, then prime minister Benjamin Netanyahu was basking in the success of the first roll-out, which he ascribed to his decision-making and influence with big pharma, claiming this enabled him to secure early shipments of the vaccine. Then, in May, he was distracted by the war in Gaza. Three weeks later he was out, replaced by Naftali Bennett, who sees himself as an expert on coronavirus — he ran for office partly on the basis of his manifesto, “How to Beat a Pandemic”. Bennett blithely predicted that “we can beat Covid-19 in five weeks”. That was over two months ago and Israel now has the second-highest level of new cases per capita in the world and the coronavirus wards that were closed in April have all reopened.

It isn’t all bad news, though. For a start, the vaccines are still working. After six months they are only 42 per cent effective against infection, but against serious illness they are still 80 per cent effective. Death rates are only half as high as they were in the previous waves and while less than 20 per cent of all Israeli adults have not been vaccinated, they account for half the cases in hospital. And now that the government has made the third dose available, it is already having an effect in boosting the resistance to infection of recipients.

The government decided on the boosters despite the World Health Organisation’s recommendation to wait until countries that have barely begun giving out first doses can get their vaccination campaigns under way. Israeli public health officials argue that since theirs is a small country, the booster doses do not impact on global supply, and that they are serving as a test-case for countries such as Britain which will give boosters in coming months. As the first country to administer booster jabs nationwide, Israel is embarking on a grand experiment. Bennett is adamant that the country will not enter a fourth lockdown, despite the rise in infections.

Vaccinations are so far keeping hospitals from being overwhelmed and experts are cautiously optimistic that the high uptake of third vaccines will keep it that way. For now, the school year is on track to begin next week. Face-masks are now mandatory again in all closed spaces and the target is for all secondary schools to be at least 70 per cent vaccinated before pupils return. The rest will be vaccinated at school within days of the start of term.

In primary schools, where under-12s cannot yet be vaccinated, there will be weekly testing. It’s a gamble, reopening schools while Israel is still at peak infection — experts calculate that one in every 100 Israelis is infected. And Rosh Hashanah, the Jewish New Year, a time of large family gatherings and communal prayers, begins on September 7.

However, Professor Doron Gazit, head of the Hebrew University’s Covid monitoring team, says: “We may actually have overestimated the danger of infection over the High Holidays. The chances of infection at family gatherings is counteracted by the reduced mobility as people travel less to work.”

Ultimately, the success of “containing” the Delta variant with booster jabs, face-masks and increased testing, while avoiding lockdown, could influence other governments’ policies on reopening schools and celebrating Christmas. It’s all eyes on Israel.


Johnson & Johnson booster shot increases antibodies to coronavirus nine-fold, company says

A booster dose of Johnson & Johnson's COVID-19 vaccine prompted a big spike in antibodies among clinical trial participants, when taken six to eight months after the first dose, the company announced on Wednesday (Aug.25).

Health officials have recommended that people vaccinated with the Moderna or Pfizer-BioNTech vaccines receive a booster dose about eight months after their second dose, due to waning immunity, Live Science previously reported. But they have not yet recommended a booster for the Johnson & Johnson vaccine, citing the lack of data.

"We also anticipate booster shots will likely be needed for people who received the Johnson & Johnson (J&J) vaccine," the U.S. Department of Health and Human services said in a statement on Aug.18. They added that they expect more data on the Johnson & Johnson booster shots in the next few weeks, and that they will "keep the public informed with a timely plan for J&J booster shots as well."

More than 14 million people in the U.S. received the single-dose Johnson & Johnson vaccine. Today's data, taken from clinical trial participants, suggests that a booster may be beneficial.

A booster dose of the Johnson & Johnson vaccine generated a nine-fold increase in antibodies compared to the level seen 28 days after the initial dose, the company reported in a statement. The data is based on two small clinical trials conducted in the U.S. and in Europe, and the company submitted the results, which haven't yet been peer-reviewed, to the preprint database medRxiv.

"We have established that a single shot of our COVID-19 vaccine generates strong and robust immune responses that are durable and persistent through eight months," Dr. Mathai Mammen, the Global Head of Janssen Research & Development at Johnson & Johnson, said in the statement. "With these new data, we also see that a booster dose of the Johnson & Johnson COVID-19 vaccine further increases antibody responses among study participants who had previously received our vaccine."

Mammen added that they will discuss potential strategies for booster doses with public health officials.

But the study looked at antibody levels and not at real-world efficacy, so it's not clear if people who get the booster shot will be less likely to be infected or to develop severe disease than those who don't, according to CNN. Still, experts are reaching a consensus that antibody levels may be indicative of the amount of immune protection, according to CNN.

Experts told NPR that while the studies were small, and didn't look at real-world protection, the findings would likely support the idea of giving booster shots to those who received the Johnson & Johnson vaccine. "It is pointing toward the utility of a second dose. I think that's reasonable," Saad Omer, a vaccine researcher at Yale told NPR.



Tone-deaf House Speaker Nancy Pelosi tweets about Women’s Equality Day after Americans killed in Kabul (PJ Media)

In hopeless speech, President Biden refuses liability for Afghanistan crisis he created (The Federalist)

Biden admits to being instructed which reporters to call on (Daily Wire)

Dumb… CENTCOM commander says U.S. sharing intel with Taliban (Fox Business)

“This is insanity”: Baffled reporters torch Biden for sharing list of U.S. citizens and allies with Taliban (Fox News)

Tropical Storm Ida is strengthening and forecast to hit the Gulf Coast as a major hurricane (TWC)

Portland explodes again in violent battles between antifa and Proud Boys (The Hill)

Feds to close troubled NYC jail where Jeffrey Epstein killed himself/didn’t kill himself (AP)

Democrat Terry McAuliffe, candidate for Virginia governor, forgot to sign form making him a valid candidate, complaint says (Daily Wire)

Getting it right on the second try: Supreme Court strikes down eviction moratorium (National Review)

Nearly 90% of rental assistance funds not yet distributed (Fox Business)

Delta Air Lines will impose $200 surcharge on unvaccinated employees (Fox Business)

Policy: How might China exploit the Afghanistan debacle? (Daily Signal)

Policy: How to regulate Critical Race Theory in schools (Manhattan Institute)




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