Friday, September 10, 2021

Pfizer breakthrough as drugmaker one step closer to rolling out Covid-killing wonder pill

PFIZER has made another breakthrough in their historic fight against COVID-19 after announcing they are one step closer to rolling out a coronavirus-killing wonder pill.

The simple pill is designed to be taken at home in the early stages of COVID-19 infection and it could be another big step forward in the fight against the virus. We have seen over the last months a variety of treatments for the virus, including the Oxford-AstraZena vaccine, created by British scientists.

While vaccines are highly effective at reducing the risk of death or getting seriously ill from contracting the virus, and things like ventilators can help to save lives to people who have been hospitalised, there is also a need for effective oral treatment.

There are currently a few pills being developed that are aimed at treating Covid, but Pfizer's is the first one to reach advanced human trials.

The drugmaker plans to trial the drug on 1,140 adults infected with the virus who are not considered to be high risk and are unlikely to suffer from serious illness or death if they catch COVID-19.

The pill, which is technically called PF-07321332, is in a category of antiviral agents called protease inhibitors.

Proteases are enzymes that are used for viral replication and protease inhibitors have been developed in the past to treat deadly diseases like and hepatitis C and HIV/AIDs.

Pfizer said in a statement: "Protease inhibitors, like PF-07321332, are designed to block the activity of the main protease enzyme that the coronavirus needs to replicate.

"Co-administration with a low dose of ritonavir is expected to help slow the metabolism, or breakdown, of PF-07321332 in order for it to remain in the body for longer periods of time at higher concentrations, thereby working continuously to help combat the virus.

"Ritonavir has previously been used in combination with other antivirals to similarly inhibit metabolism."

Martin J. Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers University, also hailed the breakthrough.

He said: "The hope is that the Pfizer drug and ritonavir together will sufficiently inhibit the SARS-CoV-2 protease to slow down the virus enough that [the] host's immune defences will overcome and eliminate it."


There Are Better Ways to Fight COVID-19 Than Mask Mandates

Even though policy should be based on accurate data, the Centers for Disease Control and Prevention is failing to accurately justify its guidance that vaccinated people wear masks.

The data clearly show that the vaccine helps people more than previous interventions, including mask mandates, and that the risk of dying from COVID-19 for the vaccinated is extremely low.

The CDC should follow the science, be transparent, and base all guidance on the data.

Originating in India, the delta variant is now the primary strain of COVID-19 here in the United States. A number of states, including Alabama, Louisiana, Florida, and Texas, have been experiencing surges in new cases and hospitalizations.

Given such concerns, the CDC investigated the delta variant’s spread last month. In a Morbidity and Mortality Weekly Report released on July 30, a number of researchers examined COVID-19 spread last month during a variety of festivities in Barnstable County, Massachusetts.

The authors made a number of claims, including that 74% of those who tested positive for COVID-19 after the festivities were fully vaccinated.

Not surprisingly, this statistic made the news headlines. For example, the day the study was released, an article on reported: “CDC study shows 74% of people infected in Massachusetts Covid outbreak were fully vaccinated.”

Given how much attention the analysis had gotten, my colleague Norbert Michel and I decided to take a look at the study in critical detail. After all, public policy should be informed by credible and accurate analysis.

We found that the study failed to look at the question at hand with sufficient rigor and does not provide support for the study’s main recommendation about mask wearing among the vaccinated.

Among the 469 who tested positive, 74% indeed had been vaccinated. However, as we discussed in our report, the data that this estimate is based on are not representative of the Barnstable attendees, let alone of the entire country. Therefore, it would be a mistake to use those estimates to make inferences of the broader American population.

Second, there’s a more fundamental question the authors neglected to look at: Infection rates in the broader context of the number of people who actually attended the festivities, both vaccinated and unvaccinated.

We also examined this question, making a variety of assumptions on available data and information. Assuming an attendance of 60,000, as has been suggested by a number of people, and a vaccination rate of 90% of attendees, we found the following infection rates.

image from

Of course, as it’s difficult to know the actual vaccination rate, we reestimated the above percentages under a variety of other assumptions as well.

At the time of publication, the state of Massachusetts and Barnstable County had adult vaccination rates above 74%, and Provincetown itself had a rate of 90%.

As the festivities may have included some out-of-state visitors as well, we decided to estimate the percentage of infections under vaccination rates between 60% and 98%.

image from

So, there you have it, under all such assumptions, less than 2% of the vaccinated attendees caught COVID-19. Irresponsible reporting suggesting that 74% of those vaccinated caught the virus, however, needlessly causes panic and will only increase vaccine hesitancy.

Although some research has indicated that the vaccines may have slightly less efficacy in preventing infection against the delta variant than prior variants, the vaccines are nevertheless highly effective at preventing hospitalization and death.

Furthermore, as a result of the CDC’s “study” on Barnstable, Massachusetts, one of the policy recommendations is that the fully vaccinated continue to wear masks in areas of high disease proliferation.

However, as Michel and I have illustrated in prior work, mask mandates do not meaningfully impact case proliferation. In an earlier Heritage Foundation special report, we statistically examined the impact of an executive order signed by Kansas’ Democratic governor, Laura Kelly, allowing each of the state’s 105 counties to take part in an optional mask mandate last year.

Our analysis did find slightly less case growth at times in the cases in which masks were mandated. However, on a monthly basis, those differences were not statistically significant and, most alarmingly, per capita cases and deaths continued to grow in both groups through most of the second half of last year.

Vaccines, on the other hand, have been largely successful, as is evident by the steep drops in case counts, followed by increases in vaccination rates over the years. Bottom line: Unlike masks, the statistics on vaccine efficacy are solid and well-established.

Of course, there will continue to be breakthrough cases, but the CDC’s own data indicate that the truth is the vaccines have had over 90% efficacy against hospitalization and death.

Not surprisingly, however, among the unvaccinated, COVID-19 can still be quite deadly, especially for the elderly and those with chronic conditions. The following chart puts those odds in perspective with other causes of death.

As the chart illustrates, however, the odds of dying of COVID-19 despite being fully vaccinated, although not zero, are slim to none. In fact, those under 65 have significantly higher odds of getting struck by lightning.

Bottom line: Mask mandates on the vaccinated will only increase vaccine hesitancy and thus only prevent our country from putting this pandemic behind us.

One of the best ways to encourage the vaccine hesitant to reconsider is not mandates, but rather to equip them with good statistical analysis, so they can work with their doctors to make informed decisions. The CDC would do well to fix this failure.




No comments: