Monday, November 08, 2021

Scientists say 'suctioning'' vaccines generates more antibodies

A 'suctioning' technique for COVID-19 vaccines may be able to provide more protection than traditional needles, a new study suggests.

Researchers tested a new type of immunization for the virus based on the ancient form of medicine known as cupping, in which heated special cups are placed on the skin for a few minutes to create suction, immediately follow a Covid shot.

They found rodents that were given the vaccine via the suction method generated antibody levels millions of times higher than a traditional injection.

The team, from Rutgers University in New Brunswick, New Jersey, says a suctioning vaccine is faster and cheaper to manufacture, and can be more widely distributed than the vaccines currently in use.

'This suction-based technique is implemented by applying a moderate negative pressure to the skin after nucleic acid injection in a totally non-invasive manner,' said senior author Dr Hao Lin, a professor in the department of mechanical and aerospace engineering at Rutgers, in a statement.

'This method enables an easy-to-use, cost-effective and highly-scalable platform for both laboratory and clinical applications for nucleic-acid-based therapeutics and vaccines.'

The team noted that with traditional vaccines, when they are injected into the arm, they are not automatically absorbed by cells.

In fact, some of it degrades before it even gets to the cells so the body can mount an immune response.

But by providing suction on the skin immediately after the shot, researchers theorized this would create strain on the skin, forcing cells to automatically absorb the vaccine.

For the study, published in the journal Science Advances, they decided to test this theory using the ancient practice of cupping.

Cupping uses special cups, which are often heated, to create suction and pull blood into the skin.

Proponents say it helps increase blood flow, relieves pain, cure headaches and treat other ailments.

A COVID-19 vaccine candidate was provided by GeneOne Life Science, a biopharmaceutical company based in Seoul, South Korea.

One group of rats received two injections of the vaccine, another group received a single injection followed by a single suction and a final group received two injections followed by two suctions.

Antibody levels were between two million and five million times higher among the two suction groups than the group that received injections alone, results showed.

'We have demonstrated an alternative, safe and effective transfection platform that yields high levels of transgene expression,' Lin said.

'The advantages also include device cost-effectiveness and manufacturing scalability and minimal requirements for user training.

'Because of the inherent advantages of DNA, not least of which is avoiding cold-chain requirements of other vaccines, this technology facilitates vaccination programs into remote regions of the world where resources are limited.'


Pfizer linked to 18 new cases of heart inflammation in Australia

The number of cases of heart inflammation in Australia linked to the Pfizer vaccine has risen to 253 from about 21.9 million doses.

There were 18 new likely cases of myocarditis in the past week, a condition that sees patients experience chest pain, abnormal heartbeat and shortness of breath.

One new blood clots case linked to the AstraZeneca jab was also recorded, taking the total to 158 cases and nine deaths in Australia from about 13.1 million doses. The confirmed case involved a 40-year-old man from NSW.

The figure was released in the Therapeutic Goods Administration Covid-19 vaccine weekly safety report on Thursday afternoon.

The youngest case classified as ‘likely myocarditis’ to date was 12 years old.

Of the cases classified as likely to be myocarditis, most of the patients experienced symptoms within three days of vaccination.

Around half of the patients were admitted to hospital with eight treated in intensive care. Most patients treated in hospital were discharged within four days.

The TGA says “the estimated reporting rates in Australia appear similar to overseas rates.”

“As we have received limited adverse event reports for Spikevax (Moderna), our analysis of likely myocarditis cases focuses on data for the Comirnaty (Pfizer) vaccine,” the medicines regulator said.

In Australia, myocarditis is reported in nearly one out of every 100,000 people after receiving the Pfizer vaccine. While it is more commonly reported in young men and teenage boys after the second dose (6.7 cases in 100,000 people) it remains rare.

Cases usually occur within 10 days and resolve after a few days following treatment and rest.

The TGA advises people to seek medical attention if they experience symptoms that could suggest myocarditis or pericarditis.

This includes: chest pain, palpitations (irregular heartbeat), fainting or shortness of breath, particularly if they occur within one to five days of vaccination.

“ATAGI advises that people who develop myocarditis or pericarditis attributed to their first dose of Comirnaty (Pfizer) should defer further doses of an mRNA Covid-19 vaccine and discuss this with their treating doctor,” the TGA says.


U.S. federal appeals court freezes Biden's vaccine rule for companies

A U.S. federal appeals court issued a stay Saturday freezing the Biden administration's efforts to require workers at U.S. companies with at least 100 employees be vaccinated against COVID-19 or be tested weekly, citing "grave statutory and constitutional" issues with the rule.

The ruling from the United States Court of Appeals for the Fifth Circuit comes after numerous Republican-led states filed legal challenges against the new rule, which is set to take effect on Jan 4.

The White House declined to comment on the ruling, and referred questions to the Labor Department, where spokespeople did not immediately respond to a request for comment.

The stay comes two days after the Biden administration unveiled the rule, which was immediately met with vows of legal action from Republican governors and others, who argued it overstepped the administration's legal authority.

The action on the private-sector vaccinations was taken under the U.S. Occupational Safety and Health Administration's (OSHA) emergency authority over workplace safety, officials said. The rule applies to 84.2 million workers at 1.9 million private-sector employers, according to OSHA.

Saturday's court order came in response to a joint petition from several businesses, advocacy groups, and the states of Texas, Louisiana, Mississippi, South Carolina and Utah. The rule is also facing separate legal challenges before other courts.

The two-page order directs the Biden administration to respond to the request for a permanent injunction against the rule by 5pm Monday.


Gov. Stitt Sticks it to Biden: 'There Will Be No Government Vaccine Mandates In Oklahoma'

Oklahoma Governor Kevin Stitt stuck it to President Joe Biden and his unconstitutional vaccine mandates, declaring that it is a "complete disregard for individual freedoms and states’ rights." Stitt added that he intends to fight the order.

“It is not the government’s role to dictate to private businesses what to do. Once again President Biden is demonstrating his complete disregard for individual freedoms and states’ rights. As long as I am governor, there will be no government vaccine mandates in Oklahoma. My administration will continue to defend Oklahoma values and fight back against the Biden administration’s federal overreach," he said.

News on 6 reports:

It's too early for a lot of companies to know what this means and how it'll be enforced, but Oklahoma Representative Kevin Hern was quick to point out the problems with what he calls a huge federal overstep.

"This looks like Putin or Xi Jinping, how they operate. He's trying to push this out there and that's what dictators do," Hern said.....

The Oklahoma Attorney General John O'Connor and the Republican National Committee both said, separately, that they are pursuing litigation against Biden's mandate, claiming it is unconstitutional and an overreach of federal government.

According to Oklahoma Commerce Department, 1,962 companies employ over 100 people in Oklahoma meaning that the federal requirements will impact 678,122 Oklahomans. Oklahoma Senator James Lankford and Representative Kevin Hern issued similar rebukes of the President.

“My family and I chose to receive a COVID-19 vaccine, and I am grateful for it. Every Oklahoman and American should have that same choice and option. Federal employees and contractors, members of our military, health care workers, and everyone else in our nation should be able to choose whether to get vaccinated. Period. The Biden proposal ignores the natural immunity millions of Americans have because they have recovered from COVID and the millions of other Americans that do not want to be forced to take a vaccine for a multitude of personal, religious, and medical reasons,” Lankford explained.

“The federal government has once again overstepped into the lives and livelihoods of American citizens,” Hern added. “Private companies, especially small businesses, are already suffocating under the oppressive restrictions put in place at the start of the public health emergency last year. My colleagues and I have warned of the slow march to socialism for years, and we were called liars for it. Turns out it’s not so much a slow march as it is a sprint. More restrictions, more mandates, more socialist policies are never the answer.”

Oklahoma AG O'Connor declared, "We respect the right of Oklahoma businesses and individuals to make healthcare decisions for themselves and their families. My office will vigorously oppose any attempt by the federal government to mandate vaccines. We are preparing litigation to stand up for our rights and defend the rule of law against the overreach of the federal government."

The RNC Chairwoman Ronna McDaniel stated, “Joe Biden told Americans when he was elected that he would not impose vaccine mandates. He lied. Now small businesses, workers, and families across the country will pay the price. Like many Americans, I am pro-vaccine and anti-mandate. Many small businesses and workers do not have the money or legal resources to fight Biden’s unconstitutional actions and authoritarian decrees, but when his decree goes into effect, the RNC will sue the administration to protect Americans and their liberties.”

Oklahoma House Speaker Charles McCall added, “The Oklahoma Legislature acted aggressively this session to stop unconstitutional federal overreach like President Biden proposed today. We saw this coming and are already prepared to block it in Oklahoma. This type of unilateral overreach is precisely why House Bill 1236 and the additional litigation funds for the attorney general were such big priorities this session. I applaud the attorney general for utilizing the tools the Legislature provided to defend Oklahoma’s rights as a state. President Biden is about to see the U.S. Constitution still matters in Oklahoma. This isn't the only unconstitutional Biden administration action Oklahoma needs to challenge. Our country is a republic of states, not a monarchy, and the president does not have the constitutional authority to issue these type of edicts.”

In other words, Oklahoma isn't playing this communist, tyranny bull crap.




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