Pfizer’s COVID-19 Vaccine Goes Into Liver Cells and Is Converted to DNA: Study
Confession: I scoffed when I heard early claims that Covid vaccine alters your DNA. It seems that reality beats the improbable as far as the Pfizer vaccine is concerned. I am glad I had the more conventional AstraZenica shot, not available in the USA due to pressure from America's Big Pharma.
The academic journal article is here. The study was of "in vitro" liver cells but cells elsewhere would presumably be similarly affected. The big question is how extensive such effects are
The messenger RNA (mRNA) from Pfizer’s COVID-19 vaccine is able to enter human liver cells and is converted into DNA, according to Swedish researchers at Lund University.
The researchers found that when the mRNA vaccine enters the human liver cells, it triggers the cell’s DNA, which is inside the nucleus, to increase the production of the LINE-1 gene expression to make mRNA.
The mRNA then leaves the nucleus and enters the cell’s cytoplasm, where it translates into LINE-1 protein. A segment of the protein called the open reading frame-1, or ORF-1, then goes back into the nucleus, where it attaches to the vaccine’s mRNA and reverse transcribes into spike DNA.
Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus.
“In this study we present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro,” the researchers wrote in the study, published in Current Issues of Molecular Biology. “BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.”
BNT162b2 is another name for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand name Comirnaty.
The whole process occurred rapidly within six hours. The vaccine’s mRNA converting into DNA and being found inside the cell’s nucleus is something that the Centers for Disease Control and Prevention (CDC) said would not happen.
“The genetic material delivered by mRNA vaccines never enters the nucleus of your cells,” the CDC said on its web page titled “Myths and Facts about COVID-19 Vaccines.”
This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldn’t occur.
The CDC says that the “COVID-19 vaccines do not change or interact with your DNA in any way,” claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response.
Pfizer didn’t comment on the findings of the Swedish study and said only that its mRNA vaccine does not alter the human genome.
“Our COVID-19 vaccine does not alter the DNA sequence of a human cell,” a Pfizer spokesperson told The Epoch Times in an email. “It only presents the body with the instructions to build immunity.”
More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose.
The Swedish study also found spike proteins expressed on the surface of the liver cells that researchers say may be targeted by the immune system and possibly cause autoimmune hepatitis, as “there [have] been case reports on individuals who developed autoimmune hepatitis after BNT162b2 vaccination.”
The authors of the first reported case of a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that “spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals” as it has been shown that “severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage,” which the virus’s spike protein appears to be responsible for.
Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. It was assumed that the vaccine’s spike protein would remain mostly at the injection site and last up to several weeks like other proteins produced in the body. But studies are showing that is not the case.
The Japanese regulatory agency’s biodistribution study (pdf) of the Pfizer vaccine showed that some of the mRNAs moved from the injection site and through the bloodstream, and were found in various organs such as the liver, spleen, adrenal glands, and ovaries of rats 48 hours following injection.
In a different study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomes—that mediate cell-to-cell communication by transferring genetic materials to other cells—for at least four months after the second vaccine dose.
The persistence of the spike protein in the body “raises the prospect of sustained inflammation within and damage to organs which express the spike protein,” according to experts at Doctors for COVID Ethics, an organization consisting of physicians and scientists “seeking to uphold medical ethics, patient safety, and human rights in response to COVID-19.”
“As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles,” they said.
Dr. Peter McCullough, an internist, cardiologist, and epidemiologist, wrote on Twitter that the Swedish study’s findings have “enormous implications of permanent chromosomal change and long-term constitutive spike synthesis driving the pathogenesis of a whole new genre of chronic disease.”
Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccine’s mRNA will integrate with the cell’s genome is unknown. The authors said more investigations are needed, including in whole living organisms such as animals, to better understand the potential effects of the mRNA vaccine.
“At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination,” the authors said.
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Explaining vaccine rejection
The 2020–2022 pandemic split parties and ideologues, separated friend from friend and family members from family members. Neighbors were dangerous, and strangers even more so: the invisible enemy stalking our lands overturned every other concern in life: The conflicts it spurred replaced bonds of affection with fear and hatred.
More than ever, we need calm and level-headed thinkers, honest and willing to admit past errors, with eyes wide open for the corruption of industry or government itself. In other words, we need as little politics as humanly possible. As I wrote in a previous piece: we need “people without a clear ideological position, and who can thus appeal to audiences across the political spectrum.”
Two sane figures recently attempted the impossible: to speak calmly to the other side, trying earnestly to explain what happened—Konstantin Kisin, of the popular show Triggernometry, and Columbia sociology professor Musa al-Gharbi.
Kisin begins his monologue with “You’re struggling to understand why some people are vaccine hesitant. Let me help you.”
He uses no study result, no appeal to the biological effect of the drug that has become the main symbol of the Covid conflict; no death rates or R0; no projection of spread or what number of lives lockdowns may or may not have saved. Instead Kisin, for 13 spellbinding minutes, walks us through the many good reasons that people had—before and during Covid—to distrust the elites in politics, business, and media. If this is a question of (dis)trusting the establishment (including “the” Science), you must ask what the establishment did to no longer deserve that trust.
The tale begins years ago, with the Brexit vote and with the election of Donald Trump. Those events shocked the pompous leaders of the universities, the pollsters who confidently said it wouldn’t happen, the media pundits who so convincingly described to us the madness of such prospects.
For a brief moment after the unthinkable had happened, if you recall, there was an earnest desire for inclusivity—for inviting in the views that had gone overlooked in the other half of these countries. Outlets like the New York Times made an effort to portray conservative views and show the kinds of people who had long felt alienated and ostracized from civilized society. As despicable and difficult it was for their core audience to see, revealing perspectives and objections is better than silencing and hiding them.
The efforts didn’t last long and in 2019 and 2020, the monolithic thoughts that dominate these institutions willingly put their blinders on—tighter and more aggressively than before.
Kisin’s final minute is the most powerful thing in these disease-ridden past two years:
“The same people who told you Brexit would never happen; Trump would never win, and that when he did win, it was because of Russian collusion, then because of racism; that you must follow lockdown rules while they don’t; that masks don’t work and then that they do; that protests during lockdowns are a health intervention; that ransacking black communities in the name of fighting racism is mostly peaceful justice; that Jussie Smollett was the victim of a hate crime; that men are toxic; that there’s an infinite number of genders; that Covid didn’t come from a lab, and then that it probably did; that closing borders is racist, and then that it’s the most important thing to do; that the Hunter Biden story is Russian disinformation, and then that it’s not; that they would not take Trump’s vaccine, and then that you must take the vaccine; that Governor Cuomo is a great Covid leader, and then that he’s a granny killer and a sex pest; that the number of Covid deaths is one thing and then another; that hospitals are filled with Covid patients, and then that many of them caught Covid in hospital.
These are the same people now telling you that the vaccines are safe, you must take it, and if you don’t you will be a second-class citizen.
Understand vaccine hesitancy now?”
https://www.theepochtimes.com/skepticism-as-a-new-way-of-life_4302371.html
***********************************************Also see my other blogs. Main ones below:
http://edwatch.blogspot.com (EDUCATION WATCH)
http://antigreen.blogspot.com (GREENIE WATCH)
http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)
http://australian-politics.blogspot.com/ (AUSTRALIAN POLITICS)
http://snorphty.blogspot.com/ (TONGUE-TIED)
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