Australia: Top doctor Luke McLindon sacked, shunned for divisive Covid research
Gynaecologist and obstetrician Luke McLindon has proved to be a headache, even an embarrassment, to the bosses at Brisbane’s Mater Hospital.
In June, the leading health facility terminated his job as the head of fertility services for not having the Covid-19 vaccine – against Queensland Health’s mandate.
And now the controversial doctor has stirred up a storm over data he says makes a preliminary link between the Covid-19 vaccine and miscarriages.
His unfinished research – which is heavily disputed by the Mater and counter to multiple studies that have found the vaccine is safe for pregnant women – was leaked and promoted by anti-vaxxers online.
Dr McLindon wants his early research to be investigated further, but his personal stance against vaccine mandates is not helping his fight for serious consideration of his findings.
“I’ve been shunned and isolated and in a very difficult place both personally and professionally,” he told The Sunday Mail. “I am not an anti-vaxxer, I’m just against mandates, and as a GP I delivered the scheduled immunisations to patients for years.
“As an obstetrician my patients were mostly all vaccinated. “I have never encouraged anyone not to be vaccinated.”
Dr McLindon, a long-time clinical researcher in infertility and recurrent miscarriage, told peers in a closed meeting that he had discovered a rise in the number of early pregnancies lost to women following the Covid-19 vaccine.
“I told the group that the rates looked too high but needed further investigation and made it clear the findings must not be spread,” he said.
“I was horrified by what I saw online. “It was used as anti-vax fodder and my actual data was not yet complete. “Those numbers were very early and they were worst possible scenario. “They needed to be moderated and adjusted as more time passed.
“News travelled fast in the medical world in Queensland and I have been distanced and frozen out.”
The doctor said at 51 he will likely have to start life again in a different career.
The Royal Australian and New Zealand College of Obstetricians and Gynaecologists recommends all people trying to conceive to have the Covid vaccine. Several studies have found the vaccine to be safe for pregnant women.
As he fights for his reputation, Supreme Court documents show the doctor lost his position at the Mater as he failed to adhere to the vaccine mandate for medical professionals.
Dr McLindon is one of a group of Queensland doctors who launched a legal challenge to the chief health officer’s vaccine mandates for hospital and healthcare workers.
“That is my personal decision due to a heart condition,” he said.
A Mater spokesman confirmed that the doctor no longer practised at the Mater but would not clarify the reason. Dr McLindon said he too was not at liberty to comment on the reason for his termination.
But court documents show that Mater chief executive Dr Peter Steer terminated his employment on June 9 as he had not complied to the vaccine mandate and did not provide an exemption.
“I wish to have peers review my findings before formally releasing,” Dr McLindon said. “The aim is to find a reputable international journal who sees the importance of this work to add to the scientific literature in this space.
“I have an intimate knowledge of these women’s menstrual cycles, time of conception, bloods, ultrasounds, vaccination status and timings.”
Colleagues say the controversial gynaecologist is a respected doctor and a “decent human being”. “Research needs to start somewhere,” one doctor said. “As experts in a field we have an obligation to be intellectually honest. “This includes being absolutely sure of your data and allowing others in the field to crosscheck your findings.”
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Better COVID-19 vaccines are on the way. What do they do? And what technology might we see in the future?
By Paul Griffin
Regulators in Australia and the United States last week approved Omicron-specific boosters, following approval in the United Kingdom in mid-August.
In Australia, a Moderna Omicron booster has been provisionally approved for use in adults aged 18 and over. Supplies are expected to arrive in the coming weeks, however the Australian Technical Advisory Group on Immunisation (ATAGI) is yet to advise the government on how the vaccine will be used.
So what's new about the Omicron booster? And what sorts of advances in vaccine technology might we see next?
Why do we need new vaccines?
The current COVID-19 vaccines will go down in history as one of the greatest achievements of medical science. Developed at record pace — without omitting any of the usual steps to ensure safety and efficacy — the vaccines significantly decreased the risk of severe disease and death.
But they're less effective at reducing infection. Frequent boosters have been required to protect against new sub-variants. This is because the spike protein, which the vaccines target, has changed. And over time, our protection has reduced due to waning immunity.
What are the Omicron-specific vaccines?
Most manufacturers of approved COVID-19 vaccines began making boosters targeting previous variants as far back as Alpha. But until Omicron, these variant-specific boosters offered no significant advantage over vaccines targeting the original, or Wuhan, strain.
The new Omicron boosters combine two different targets in the one vaccine, known as a bivalent vaccine. This provides broader cross-protection — against the currently circulating variants but possibly against future variants too.
The first of these boosters, manufactured by Moderna, targets the BA.1 Omicron sub-variant in addition to the original or Wuhan strain. It also provides some protection against BA.4 and BA.5. This is now approved in the UK, Australia and US.
The US has also approved the Pfizer bivalent booster, which targets the spike of BA.4/BA.5 as well as the original strain.
What vaccine technology might we see next?
Scientists are working to develop COVID-19 vaccines that:
offer longer lasting protection
protect against new variants and sub-variants
provide similar levels of protection from a single dose
don't require freezing or refrigeration, and that have an extended shelf life
deliver a strong response from lower doses of active ingredient.
More than 120 potential COVID-19 vaccines are in clinical trials. Here are some of the improvements they're working on.
More robust protection against new variants
Most vaccines approved so far target the entire spike protein. But many vaccines under development specifically target the part of the spike protein that binds to the corresponding receptor on our cells. This is less likely to change than other parts of the spike protein, delivering more robust protection against new variants.
Candidate vaccines using this approach include Icosavax and one from the Serum Institute of India.
Easier storage
DNA-based vaccines are similar to mRNA vaccines (Pfizer and Moderna) but are more temperature-stable, making them easier to transport and store. One such vaccine, by manufacturer Zydus, has already received an emergency use authorisation in India and is injected into the skin. Another, by Inovio, is undergoing phase three trials.
Greater immune responses from lower doses
With current COVID-19 vaccines, the body is given instructions to make the spike protein, or the spike protein itself is delivered. The vaccines cannot replicate or reproduce themselves. Vaccines that can replicate have the potential to generate stronger immune responses or strong enough responses from lower doses.
Variant-proof vaccines
Finally, many vaccines under development have the ambitious target of protecting against all coronviruses or vaccines that are essentially variant-proof. While this has not so far been achieved for any similar family of viruses, there are many promising candidates.
Many rely on combining antigens from many different parts of the virus or even multiple coronaviruses. Others combine multiple receptor-binding domains (potentially allowing the vaccine to give a broader immune response against a range of variants) with other innovative technologies.
Different routes of administration
Current vaccines rely on administration via a needle and syringe. This is an issue for people with needle phobias, and presents challenges for the disposal of sharps. So many vaccines being developed are given via alternate routes.
One way to deliver vaccines is through the nose, known as intranasal vaccination. Rather than injecting, you breathe it in.
Giving the vaccine via the same route the virus gains entry has the potential to generate a response that's better able to stop the virus entering in the first place.
One of the main limitations of nasal vaccines is getting a strong enough immune response to be effective. However there are many promising candidates, including one I'm working on.
Vaccines given via the skin are also a promising area. In addition to the DNA vaccines injected into the skin, others are being developed using vaccine coated onto patches, essentially made of microscopic needles. This is easier to administer.
It may also have some advantages in terms of immune response and its ability to be stored at room temperature. One such vaccine that looks promising has been developed by a group originally from the University of Queensland.
Finally, oral vaccines you drink are also under development. While potentially the most convenient method of administration, it's also one that poses great challenges in terms of getting a strong enough response for the required effect.
While up to five vaccines in development are exploring this avenue of administration, including one I'm involved in, they are in relatively early phases of clinical trials.
https://www.abc.net.au/news/2022-09-05/covid-omicron-vaccine-booster-target-omicron/101401478
****************************************************Also see my other blogs. Main ones below:
http://edwatch.blogspot.com (EDUCATION WATCH)
http://antigreen.blogspot.com (GREENIE WATCH)
http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)
http://australian-politics.blogspot.com/ (AUSTRALIAN POLITICS)
http://snorphty.blogspot.com/ (TONGUE-TIED)
https://immigwatch.blogspot.com/ (IMMIGRATION WATCH)
https://awesternheart.blogspot.com/ (THE PSYCHOLOGIST)
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