Thursday, November 03, 2022



The naked authoritarianism of the pandemic response is unforgiveable

Forgiveness is now officially on the Covid menu. The left-leaning Atlantic magazine in the US has called for a ‘pandemic amnesty’ in which people ‘forgive one another for what we did and said’ during Covid. At issue is the question of school closures and other restrictions and mandates now deemed excessive. The Atlantic is something of a mouthpiece for Joe Biden’s hopeless Democrats, but in this instance the article is actually worth paying attention to. Not because of any particular insights but because of the distinct whiff of fear that oozes out of every other sentence.

‘But the thing is: We didn’t know,’ the author whines (in italics!), claiming ignorance as a defence against implementing erroneous Covid polices because she was operating under conditions of ‘tremendous uncertainty.’ ‘We lacked definitive data.’ ‘It wasn’t nefarious. It was the result of uncertainty.’ ‘Obviously some people intended to mislead…’. As well as this bizarre post-rationalisation: ‘In some instances, the right people were right for the wrong reasons. In the face of so much uncertainty, getting something right had a hefty element of luck.’

Well, no. In some instances the right people were right for the right reasons. At The Spectator Australia in particular, where a veritable army of writers including Rebecca Weisser, Ramesh Thakur, James Allan, David Flint, David Adler, Rocco Loiacono, Augusto Zimmerman, Alexandra Marshall and many others risked opprobrium and worse for writing for the correct reasons – out of principle, out of conviction and out of sound research.

Indeed, a recent (much-appreciated) letter to the editor of this magazine spelled out the rewards of such an approach;

‘You and your team were like a light shining through the darkness of Covid hysteria. It meant a lot to my wife and I that we were not the only ones saying “what the hell…?” I am a former journalist (what has happened to our profession?) and I look forward to The Spectator Australia every week. The quality of writing is first rate but it is the fearless pursuit of truth which is truly outstanding. Your work is critical for public discourse in Australia as our political class, big business, media, bureaucracy and educational system all seem to have been captured by nonsense and wokeism.’

It is because of ‘uncertainty’ that in a democracy we supposedly seek a plurality of views on difficult issues, and we insist on accountability. By ensuring that as many people as possible get exposed to as many ideas as possible we hopefully avoid compounding bad thinking, and we trust the public – rather than the authorities – to make those final decisions that affect our lives and livelihoods.

It is utterly disingenuous for those who made such catastrophic and reckless mistakes during Covid to now say that ‘they didn’t know’ about such-and-such an outcome because of the ‘fog of uncertainty’ and that the alternative to their authoritarian overreach and draconian measures was ‘millions of dead bodies’. These same individuals deliberately and ruthlessly suppressed anyone who did try to shed some light on potential risks, problems or alternatives to the orthodoxy.

Many people were horrified by the police brutality, by the obfuscation and lies surrounding vaccine mandates, and were repelled by the QR codes and having their kids being forced to stay home or wear worthless masks all day long. But the censoring of them and the humiliation meted out to them was merciless. Dr Jay Battacharya was just one of many brave experts who spoke out early and loudly warning that lockdowns would not only fail but would cause more deaths than they could ever possibly save, not to mention doing untold economic damage.

Yet for speaking out he was demonised and hounded out of the public square. For merely asking questions, the Greens in the Australian Senate smeared and vilified the editor of this magazine in his role at Sky News along with Rita Panahi and Alan Jones. Gideon Rozner at the IPA cut a solitary figure in Melbourne when he did a video pleading for lockdowns to end in Melbourne and was vilified and demonised remorselessly.

So let’s skip the ‘fog of uncertainty’ nonsense. There were plenty of voices warning against nearly all of the policies that were being enacted, often brutally so, but rather than such plurality of opinion being encouraged, those voices were viciously silenced, humiliated, denigrated and demonised. It’s called wilful ignorance and it is no defence under the law.

But get used to hearing this argument that nobody knew any better. That it was all so confusing and we all did our very best. Plenty of people did know better and did try and speak up.

The Atlantic author claims that ‘dwelling on the mistakes of history can lead to a repetitive doom loop…. Let’s acknowledge that we made complicated choices in the face of deep uncertainty…’.

No. Let’s have a royal commission into the abuse of power during Covid, and a Senate inquiry, too, for good measure. To ensure this never happens again.

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Unvaccinated, COVID-19 Infected Identified with 90%+ Humoral Protection Against SARS-CoV-2 for 20 Months

Natural immunity is powerful and long-lasting

Carlota Dobaño, Anna Ramirez-Morros, as well as physician-scientists at both ISG Global Hospital Clinic, University of Barcelona, and other Spanish academic research institutions, conducted a longitudinal cohort study involving 247 Barcelona-based primary health care workers who were infected with SARS-COV-2, the virus behind COVID-19.

Assessing natural SARS-CoV-2 induced levels of immunoglobulins M (IgM), G (IgG), and A (IgA) in response to the spike as well as nucleocapsid proteins associated with the novel coronavirus, the Spanish researchers tracked the patients for 616 days covering the range when they were first tested positive to SARS-CoV-2. Both the vaccinated and those who were previously infected and benefited from natural immunity both face risk with waning humoral immunity combined with mutating variants of SARS-CoV-2—the latter leading to the emergence of immune-evading pathogens.

Both of these dynamics can lead to vulnerabilities associated with risk for COVID-19 reinfection. While studies and real-world observations find association with comorbidities and COVID-19 severity, the impact of comorbidity on residual antibody levels (from previous infection) hasn’t been studied. The authors detected a robust natural immunity as measured in humoral protection against SARS-CoV-2 among unvaccinated health care workers subjects.

Humoral Responses

While the richest economies developed vaccines for a mass vaccination program in response to the COVID-19 pandemic, a sizable number of the human population around the world has yet to be vaccinated. While many of this global cohort survive based on natural induced antibodies (assuming they have been infected with SARS-CoV-2) how robust is this natural immunity? While studies have demonstrated that it may be active for one year or more, apex research institutes such as the National Institutes of Health (NIH) centered their research investment on vaccine-induced immunity, largely avoiding the topic of natural immunity until they absolutely had no choice but to include it in discussions. But now long does natural immunity persist?

With the vaccines, a primary measure of effectiveness is the inducement of neutralizing antibodies against SARS-CoV-2. But the humoral immune response to the novel coronavirus represents another vital immunity response. This class of immunity consists of immunoglobulins in reaction to SARS-CoV-2 viral antigens (spike and nucleocapsid proteins). When a person is first infected, IgM and IgA represent key humoral responses, while later, the immune response centers on IgM and IgG neutralizing actions.

The Study

The study is a real-world evidence study involving 247 health care workers from Barcelona, Spain who were diagnosed as positive for SARS-CoV-2, the virus behind COVID-19. The study team collected samples covering different time points between March 2020 and November 2021. The goal of this study: to identify and quantify the impact of comorbidities on antibody response to COVID-19. Comorbidities included autoimmune disease, cancer, obstructive pulmonary disease, and more.

How were antibody responses quantified?

The investigators evaluated levels of IgG, IgA, and IgM against the spike protein, subunit S2, nucleocapsid protein, receptor binding domain (RBD), and the C-terminal region of the pathogen while seeking to better understand how antibody levels modified over time.

Results

In what could be considered stunning results, naturally induced antibody levels, as measured by seropositivity against the novel coronavirus, remained cumulatively over 90% even a year after the initial infection. Yes, the level of natural immunity as measured by humoral response proxies gradually declined leading to materially less protection, however, the 90% level of protection persisted during the study period.

For example, Dobaño, Ramirez-Morros, and team report a 95.65% seropositivity rate in the unvaccinated cohort with 95.65% (IgA and IgG) in response mostly to the spike protein as well as RBD-responses that were lower (IgA and IgM), at 47.83%.

Interestingly, while RBDs associated with both Alpha and Delta were associated with comparable IgG seropositivity, as to the wildtype (original) strain, Beta and Gamma variants of concern were associated with lower seropositivity levels.

Low Reported Reinfection Rate

The robustness of humoral powered natural immunity was considerable given that the subjects of this study—again health care workers from Spain who were not vaccinated but were infected by SARS-CoV-2 in the past—experienced a COVID-19 reinfection rate of only 3.23%.

Multivariate regression models suggested comorbidities from fever and hospitalization to smoking, obesity, and other factors associated with lower antibody levels. A year later, antibody levels associated with age, occupation, hospitalization, duration of symptoms, and a host of other factors.

Stable persistence of IgG and IgA responses and cross-recognition of the predominant variants circulating in the 2020–2021 period indicate long-lasting and largely variant-transcending humoral immunity in the initial 20.5 months of the pandemic, in the absence of vaccination.

Conclusion

The authors point out that those health care workers that didn’t get vaccinated experienced robust antibody levels even up to approximately 1.7 year with seropositivity over 90% up to 20.5 months after COVID-19 symptom onset.

The authors point out:

“The maintenance of anti-S IgG, whose levels highly correlate with neutralizing antibodies, appears to be clinically relevant in protecting individuals particularly against the wild type and Alpha variants, despite lack of vaccination, consistent with having symptomatic infections in low responders, and those reinfected with the more transmissible Delta variant.”

Furthermore, the Spanish team reports that the “antibody kinetics after natural infection appear to be stably sustained, more so than after vaccination, which has led to the implementation of booster immunizations, particularly in the face of more contagious VoCs like Omicron.”

The authors remind that individuals who benefit from natural immunity also gain further protective benefit from vaccination, as unfolding study data suggests so-called hybrid immunity offers the greatest protection against COVID-19.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH)

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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