COVID-19 mRNA Vaccine Impacts on Menstrual Cycles—The Unfolding Science

A recent study led by researchers at Boston University (BU) looked into the impact of COVID-19 vaccines on menstrual cycles.The researchers sought to better understand what have been many anecdotal reports that vaccines were changing women’s periods. Reports of cycles arriving earlier with heavier bleeding were relatively commonplace. Interestingly, the recent study results represented by corresponding author Amelia Wesselink, Ph.D., MPH Department of Epidemiology, BU’s School of Public Health reported that indeed, there can be observed changes in menstrual cycle, however, such changes are likely not the fault of the COVID-19 vaccines but rather the result of individual’s immune system reacting to the vaccine.

Yet this very answer implies an impact of the vaccine. What do other studies suggest? The overall data ranges but generally, point to some impact of COVID-19 vaccination on menstrual cycle, at least temporarily. Of course, long term study data is needed.

In an underlying prospective cohort study, the BU-led researchers found one-day average delay I menses plus a higher incidence of long menstrual cycles post COVID-19 vaccination. However, these deviations mostly were resolved by the next menstrual cycle. The study team argued, “Other menstrual cycle characteristics, including cycle regularity, bleed length, heaviness of bleed and menstrual pain, were not strongly associated with COVID-19 vaccination.”

What are the findings of another research?

TrialSite has covered the topic as objectively as possible, chronicling several studies involving menstrual cycles and COVID-19 vaccines. For example, a retrospective study published in the journal Women’s Health found some interesting results. Led by Maria Christina Martinez-Avila, a clinical epidemiologist at the BIOTOXAM Research Group, University of Cartagena, the team conducted via survey across targeted social networks. The Columbian investigators queried 950 women in the 18–41-year age range between July and September 2021, to better understand the impact of COVID-19 vaccination on menstrual cycles. Ultimately, 408 of the subjects met the inclusion criteria. The study authors concluded that “SARS-CoV-2 infection and COVID-19 vaccination can influence the menstrual cycle and cause alterations.” This class of study comes with limitations.

In another piece in 2021, TrialSite surveyed unfolding reports of menstrual cycle issues possibly linked to the COVID-19 vaccines.

In the heavily vaccinated Mediterranean nation social media was abuzz during 2021, with women sharing their experiences, ranging from irregularity to unusual amounts of bleeding. In other cases, postmenopausal women report bleeding. At the same time, medical establishment experts cannot explain the observations or even link such a phenomenon to the jabs, perhaps in part, because these observations could be associated with any number of other causes.

Regardless of the ever-growing number of complaints after vaccination by 2021, clinical investigators sought to study the situation in more detail. For example, the American government has put $1.76 million to study the subject in a study led by Johns Hopkins University’s Mostafa Borahay, M.D., Ph.D., associate professor of gynecology and obstetrics at Johns Hopkins University School of Medicine. In Israel, chairman of the Israel Society of Obstetrics and Gynecology, Professor Roni Maimon of Shamir Medical Center, initiates Israel’s first investigation into the matter.

By early 2022, another major National Institutes of Health (NIH) funded study sponsored by Oregon Health and Science University (OHSU) and led by Dr. Alison Edelman, a professor of obstetrics and gynecology, demonstrated that COVID-19 vaccination can cause changes to the timing of menstruation. A survey conducted by anthropologists found numerous reports of unusually heavy flows and even breakthrough bleeding among some people who hadn't menstruated in years. However, the results of the study also show the effects are temporary.

By quarter one 2023, Dr. Peter McCullough reported that according to the “EVA Project,” 78% of participating women reported at least some menstrual changes post COVID-19 vaccination. In regard to both the Pfizer-BioNTech and Moderna vaccines, McCullough wrote, “Both forms of the vaccine use lipid nanoparticles which for years have been known to be taken up by reproductive glands (ovaries and testes) and dump their payload of genetic code for the WIV BA4/BA5 Spike protein which starts producing the tissue damaging Spike within an hour .” The mainstream fact checkers would label this “misinformation” but was it fully that?

The outspoken critic of the COVID-19 vaccines continued:

“The mRNA is now known to circulate in the bloodstream for 28 days and continues to bombard the ovaries with more mRNA throughout the ovulatory cycle. Genetic vaccines loaded on lipid nanoparticles, are almost by design as depicted by Wang et al. destined to influence ovulatory cycles, gametocyte production and viability, thus interfering with the complex and delicate reproductive cycle of human beings.”

By April 2023, TrialSite reported that even the mainstream Washington Post was allowing editorials with a critical view of the mRNA jabs. Were they impacting women’s menstrual cycles?

Arnie Mazer reported for TrialSite that in the recent editorial, Kate Clancy, a biological anthropologist and professor at the University of Illinois, wrote about how after she received her first dose of the Covid vaccine she got her period, and the bleeding was so heavy she “was swapping out overnight-strength pads every hour.”

In one TrialSite reporter’s review of possible COVID-19 vaccine side effects, Simay Bayatli shared case series involving alternations to menstrual cycles associated with the COVID-19 vaccine. Yet this evidence isn’t as strong.

In an opinion piece, Ronald Kostoff showcases the high number of menstrual issues reported in association with the COVID-19 vaccines when compared to influenza vaccine. This data was derived from the Vaccine Adverse Event Reporting System, which was designed to detect safety signals, but individual cases are often not conclusive proof as often they are not adjudicated.

A group of outspoken critics of the COVID-19 vaccines, including McCullough and women’s health physician Dr. James Thorpe and others, again used VAERS data to identify safety signals involving menstruation.

The group, criticized by the medical establishment, reported that “COVID-19 vaccines, when compared to the Influenza vaccines, are associated with a significant increase in AE with all proportional reporting ratios of > 2.0: menstrual abnormality, miscarriage, fetal chromosomal abnormalities, fetal malformation, fetal cystic hygroma, fetal cardiac disorders, fetal arrhythmia, fetal cardiac arrest, fetal vascular mal-perfusion, fetal growth abnormalities, fetal abnormal surveillance, fetal placental thrombosis, low amniotic fluid, and fetal death/stillbirth (all p values were much smaller than 0.05). When normalized by time-available, doses-given, or persons-received, all COVID-19 vaccine AE far exceed the safety signal on all recognized thresholds.”

Thorpe et al. concluded in a preprint that pregnancy and menstrual abnormalities are significantly more frequent following COVID-19 vaccinations than that of influenza vaccinations.” Again, mainstream critics would argue that self-reported cases in VAERS isn’t necessarily conclusive proof.

The Centers for Disease Control and Prevention (CDC) organized a working group looking into the matter. The VSD Menstrual Irregularities Working Group (MI-WG) protocol sought an evaluation of possible association between COVID-19 vaccination and abnormal uterine bleeding. In partnership with Kaiser Permanente, their researchers included Stephanie Irving, Tia Kauffman, Allison Naleway, Kim Vesco, Michelle Henninger while CDC VSD Site Investigators included Heather Lipkind, Malini DeSilva; and CDC Investigators included Naomi Tepper, Christine Olson and Eric Weintraub.

The CDC-sponsored investigation included “Background Reports” acknowledging that “menstrual irregularities following COVID-19 vaccine have been increasing, especially on social media platforms and in the Vaccine Adverse Event Reporting System.”

The reports prompted the National Institutes of Health (NIH) to release a Notice of Special Interest for investigating these claims. While there are a handful of publications around menstrual changes and COVID-19 infection, the conclusions range from “women should be reassured that SARS-CoV-2 has no impact on abnormal uterine bleeding (AUB) of any type including the symptoms of heavy and/or irregular menstrual bleeding” to “patients had various extents of transient menstrual changes, mainly manifesting as prolonged cycles and decreased volume.”

This research team shared a report of one study indicating 16% of female or non-binary patients with COVID-19 infection reported changes in menstruation, which correlated with a greater number of COVID-19 symptoms. See the link.

A large observational study in Sweden found that COVID-19 vaccination was not tied to an increase in hospital admissions or visits with a healthcare professional due to menstrual changes or bleeding in premenopausal women. This study included 2,946,448 Swedish participants aged 12 to 74 years.

The study team did report, “Postmenopausal women were more likely to have contact with the healthcare system because of vaginal bleeding in the months following their shot compared with when they were unvaccinated, with the highest risk after the third dose, although the associations were weak.”

“These findings do not provide substantial support for a causal association between SARS-CoV-2 vaccination and healthcare contacts related to menstrual or bleeding disorders,” the researchers wrote in The BMJ.

The EMA COVID-19 vaccine safety update identified the distinct possibility of an association of menstrual irregularities, such as heavy menstrual bleeding, to the Moderna mRNA vaccine (mRNA-1273).

Prasad S. Nishtala, Department of Life Sciences, University of Bath and colleague conducted a systematic review of safety incidence associated with COVID-19 vaccines including menstrual cycle and other related issues.

One cohort study examined reports made to V-Safe, finding that from 63,815 respondents who reported irregularities or vaginal bleeding, 41.9% received the mRNA-1273 vaccine, demonstrating a plausible link between mRNA-1273 and menstruation. See the study.

One study suggests that “many of these reports could be a case of positive rechallenging where the menstrual change has occurred after the first dose and has resumed following the second dose, indicating the possibility that the vaccine has triggered the irregularities.” See EMA report.

Prasad Nishtala and colleague reports that the study could confirm this hypothesis, meaning more monitoring is necessary.

According to another study, menstruation represents “a process of endometrium shedding, which occurs monthly as the body discards the buildup of the uterus lining and is regulated by levels of estrogen and progesterone hormones.” See the link.

The UK-based study authors point out that the immune response to the Moderna mRNA COVID-19 vaccine may lead to the endometrium (a component of the immune system) to adapt its immune environment to protect the uterus leading to abnormal menstrual changes such as those observed, as suggested in a piece published by the University of British Columbia.

Yet the phenomenon of menstrual irregularities, common with women, can also be observed in the absence of COVID-19. Can a true correlation between Moderna’s mRNA COVID-19 vaccine and such irregularities be established, especially if select studies cannot compare incidence with baseline rates? See the link.

In another study, Edelman A, Boniface ER, Benhar E, et al., “Association between menstrual cycle length and coronavirus disease 2019 (COVID-19) vaccination: a U.S. Cohort Obstet Gynecol. 2022,” the group investigated menstrual cycle data between vaccinated and unvaccinated individuals finding that less than 1-day change in cycle length in association with both COVID-19 vaccine doses (0.64 day-increase (98.75% CI 0.27–1.01). Of this population, 35% had received the mRNA-1273 vaccine. The authors suggest the boost in cycle length is mostly driven by persons who received their COVID-19 vaccine doses within a single cycle period.

In 2023, Iranian investigators from University of Tehran had their systematic review published in the August 2023 edition of the Journal of Reproductive Immunology, finding that 1) many women experience menstrual disturbances post COVID-19 jab 2) vaccine-induced menstrual disturbances raises the concern among reproductive-age women and 3) COVID-19 vaccines can lead to menstrual disturbances through changes in immune and endocrine pathways.

As observed above, is it a bit disingenuous to evade vaccine root cause by pointing to an immune system response?

https://www.trialsitenews.com/a/covid-19-mrna-vaccine-impacts-on-menstrual-cyclesthe-unfolding-science-1f1ba7e6

*************************************************

Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH)

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

***************************************************