Thursday, March 21, 2024
New Canadian vaccine works
As SARS-CoV2 evolves into more distant Omicron variants, companies continue to invest in research and development and potentially vie for lucrative government contracts for future COVID-19 vaccine deals. In this context, the Canada based Providence Therapeutics mRNA platform appears to support the acceleration of next-generation COVID-19 vaccine candidates.
Researchers affiliated the clinical-stage mRNA platform company developing vaccines for cancers and infectious disease, report on a study comparing their investigational mRNA vaccine with the Pfizer-BioNTech COVID-19 vaccine BNT162b2 (Comirnaty). When considering this approach to mRNA vaccine development the company touts its “dynamic and adaptable responses, emphasizing the importance of sustained vaccination strategies.”
How did the Canadian company’s experimental vaccine targeting COVID-19 compare against Pfizer-BioNTech BNT162b2 in a Phase 2 clinical trial?
With results of this study (NCT05175742) published in Nature Scientific Reports, the study team based out of Canada reports on the results of the head on comparison study leveraging trial sites in Canada and South Africa.
The Study
In this investigation, the sponsor-funded study looks at their COVID-19 vaccine called PTX-COVID19-B mRNA Humoral Vaccine, developed to prevent COVID-19 in a general population. Importantly, the Pfizer-BioNTech vaccine does not stop viral transmission but reduces the probability of morbidity and mortality.
For comparison of the vaccines, the study’s protocol was designed to produce the data to evaluate the safety, tolerability, and immunogenicity of PTX-COVID19-B compared to Pfizer-BioNTech COVID-19 vaccine in healthy seronegative adults aged 18 to 64.
An observer-blind, double-dummy, randomized immunobridging phase 2 study, the researchers compared the immunogenicity induced by two doses of 40 μg PTX-COVID19-B vaccine candidate administered 28 days apart, with the response induced by two doses of 30 µg Pfizer-BioNTech COVID-19 vaccine (BNT162b2), administered 21 days apart, in Nucleocapsid-protein seronegative adults, again ranging in age from 18–64 years.
The study team reports that both vaccines were administrated via intramuscular injection in the deltoid muscle. Two weeks after the second dose, the neutralizing antibody (NAb) geometric mean titer ratio and seroconversion rate met the non-inferiority criteria, successfully achieving the primary immunogenicity endpoints of the study. PTX-COVID19-B demonstrated similar safety and tolerability profile to BNT162b2 vaccine.
Importantly, a non-inferiority trial is a study that determines if a new treatment is not worse than an active treatment it is being compared to. These trials are used when a placebo (an inactive treatment) cannot be used, or when the incremental benefits of newly developed treatments may be only marginal over existing treatments, which appears to be the case here.
While NAb with lowest response was detected in subjects with low-to-undetectable NAb at baseline or no reported breakthrough infection, the study investigators also found that the study result demonstrates induction of cell-mediated immune (CMI) responses by PTX-COVID19-B.
Cell-mediated immunity (CMI), also known as cell-mediated immune response or cell-mediated immune defense, is a crucial aspect of the immune system's defense mechanism. It involves specialized cells, primarily T lymphocytes (T cells), which directly attack and destroy infected or abnormal cell
Summary
According to the entry, the candidate PTX-COVID19-B demonstrated favorable safety profile along with immunogenicity similar to the active comparator BNT162b2 vaccine.
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Now That Puberty Blockers Have Been Banned, it’s Time to Ban Covid Vaccines for Children Too
Puberty blockers have finally been banned in the U.K. The decision came after an independent review of services for children under 18 and a sharp rise in referrals to the Gender Identity Development Service run by the Tavistock and Portman NHS Foundation Trust, which is closing at the end of March.
“We have concluded that there is not enough evidence to support the safety or clinical effectiveness of puberty-suppressing hormones” an NHS spokesperson told the Telegraph on March 12th 2024.
MPs and media personalities have come out in support of this move. But in reality, most of them have remained silent on this issue up until now. It has previously been considered too politically sensitive and controversial to comment on, with the threat of being branded a ‘transphobe’ or ‘bigot’ no doubt playing a significant role in their collective silence. Nonetheless, I have yet to meet a single person, outside of social media, who agrees that puberty blockers are either ethical or safe. Thankfully, strong and courageous voices, such as J.K. Rowling, Allison Pearson, Molly Kingsley and Jordan Peterson have been calling out the dangers of this practice from the start. They are now clearly vindicated.
When the issue is stripped back to its essence, puberty blockers have been banned on the basis of long established medical ethics. Specifically, that children should never be given a medical intervention which they do not need and which poses known and serious risks to them – a view which before 2020 would have been the reasonable position to take. Indeed, to argue otherwise would have been regarded as extreme. The factor which changed after 2020 was the rollout of the Covid vaccines to children. Seemingly overnight, medical ethics was suspended and inverted in favour of pushing ahead with the vaccine rollout. However, if we apply the same principles behind the banning of puberty blockers to the Covid vaccines, they would also be banned for children with immediate effect.
The Covid vaccine rollout to children has always been controversial. Consider:
Covid vaccinations were not recommended by the Joint Committee on Vaccination and Immunisation (JCVI) for under-16s, a decision overridden by the Chief Medical Officers in England, Wales, Scotland and Northern Ireland.
When Matt Hancock was Health Secretary, he stated in Parliament that the Covid vaccines were for the adult population only. He said that children would not be offered the vaccine because it had not been tested on children and that they were at low risk from Covid. Despite this, he then supported the rollout to the nation’s children.
There are still no long-term safety data for the Covid vaccines (and at the time of the rollout to children, incomplete short-term and no medium-term safety data).
Covid vaccines pose known and very serious risks (these include potentially fatal myocarditis, pericarditis etc.) Tragically, there have also been coroner confirmed deaths caused by the Covid vaccines.
A child can still catch and spread Covid when vaccinated against the virus.
Healthy children are at extremely low risk of serious illness from Covid, so the risks posed by the vaccines outweigh any possible benefit for a child.
When Sajid Javid was Health Secretary, he stated that 12 to 15 year-old children would have the final say on whether or not to receive the Covid vaccine. Children were told that they were allowed to override their parents’ decision. This remains, in my opinion, the most egregious act of the entire pandemic.
The Government chose Pfizer, the pharmaceutical company with a long history of criminal and medical negligence (and which paid the biggest criminal fine in U.S. history) as the company to provide the Covid vaccine for our children. This really should have been a red flag from the start.
One of the most controversial points was the decision by the U.K. Government to shut down its own Ethics Committee when its members raised serious concerns about the Covid vaccine rollout to children.
Like puberty blockers, the general public appears to have been opposed to the Covid vaccine rollout to children. In the end, 89.4% of five to 11-year-olds did not receive a single Covid vaccine or booster. This is despite a multi-million pound marketing campaign directed at children and their parents. Over 50% of the 12-15 year old cohort did not receive a single dose either.
The evidence keeps stacking up against the Covid vaccines
MPs have said they believe the MHRA were aware of heart and clotting issues caused by the Covid vaccines in February 2021 but did not highlight the problems for several months. The all-party parliamentary group (APPG) on pandemic response and recovery raised “serious patient safety concerns”, claiming that “far from protecting patients” the regulator operates in a way that “puts them at serious risk”. Some 25 MPs across four parties wrote to the Health Select Committee asking for an urgent investigation.
The group also warned that the MHRA Yellow Card reporting system – which encourages patients and doctors to flag-up medicine side effects – “grossly” underestimates complexities, and in some instances picks up just one in 180 cases of harm.
MPs and peers have also accused the Health Secretary of withholding data that could link the Covid vaccine to excess deaths, and criticised a “wall of silence” on the topic. A cross-party group has written to Victoria Atkins to sound alarm about the “growing public and professional concerns” at the U.K.’s rates of excess deaths since 2020.
With the growing evidence that something is seriously amiss with the Covid vaccines, surely we should stop giving them to our children? Currently within the U.K., children who are considered vulnerable (including those with Autistic Spectrum Disorder and ADHD) and those living with clinically vulnerable adults are eligible for the vaccine. It is also possible for parents to privately purchase the Covid vaccine for their children if they are 12 years old or over. In light of the ban on puberty blockers, it makes sense to apply this thinking to the Covid vaccines too.
Things will change when members of the public speak up
Being critical of puberty blockers will become the accepted narrative now that they have been banned. Members of the public, media personalities and politicians will begin to openly express this position (which has always been the majority view). However, we need to get to a point when people begin to express opinions which they genuinely hold but are still considered controversial. Expressing lawful opinions about sensitive topics, particularly when it comes to safeguarding children against harm, should be encouraged and not vilified.
All of the safeguarding training across workplace sectors is easily dismantled and destroyed in the face of moral cowardice. As a former headteacher, with 30 years’ experience within the education sector, I had to attend annual safeguarding training which laid out what an education professional must do when he or she has concerns about a child. The training always highlighted examples in which entire organisations have been complicit in widespread abuse.
We are told that it is not just the perpetrators of the abuse who are accountable. Those who are not directly involved in the abuse, but who remain silent about it, are equally accountable under law. These individuals, woefully lacking in moral courage, place their self-preservation ahead of the needs of the children in their care. It is also a serious breach of their legal duty to safeguard children against harm.
Of course, cancel culture, as well as employers evangelised by whatever the latest thing happens to be, inhibits free speech. If an opinion goes against the current narrative, employees are likely to be attacked for expressing it. Whether that be criticism of puberty blockers, the Covid vaccines, climate alarmism, drag queen storytime or anything else. Expressing lawful opinions about controversial and politically sensitive topics will almost always result in some sort of attack. However, we must draw a line when it comes to safeguarding children against harm.
As the only U.K. headteacher to publicly express concerns about lockdowns, masking kids and the Covid vaccines for children, I have experienced multiple attacks and personal losses. This is why I am now taking my former employer, East Sussex County Council, to court. In the end, expressing my valid concerns in a lawful and moderate manner cost me my career. My employer tried to silence me through the complaints and investigation process, but I continued to express my concerns. I was fulfilling my legal and moral duty in doing so. My philosophical belief in the importance of critical thinking, freedom of speech and safeguarding children underpins my case. It is predicted to set an important legal precedent for free speech in the workplace and has gained the overwhelming support of the public, high-profile free speech advocates and the Daily Telegraph.
But it needn’t result in expensive court cases and conflict if everyone expressed their lawful opinions about the things which matter. The ban on puberty blockers is a fantastic development in the battle to protect our children, but those who were silent about it are partly responsible for the delay. This abhorrent medical intervention should have been banned long ago. The same principles applied to the ban on puberty blockers should now be applied to the Covid vaccines for children. Children do not need this medical intervention, which is ineffective and known to cause harm. The general public is clearly in agreement so the time to speak up about it is now. Silence should never be an option when safeguarding children against harm.
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Also see my other blogs. Main ones below:
http://edwatch.blogspot.com (EDUCATION WATCH)
http://antigreen.blogspot.com (GREENIE WATCH)
http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)
http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)
http://snorphty.blogspot.com (TONGUE-TIED)
https://immigwatch.blogspot.com (IMMIGRATION WATCH)
https://awesternheart.blogspot.com (THE PSYCHOLOGIST)
http://jonjayray.com/blogall.html More blogs
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