Tuesday, October 03, 2023

Do COVID-19 Vaccines Link to Cancer? 3/4 Reviewers Accept but Frontiers in Oncology Reject Manuscript

A recent paper uploaded to the Authorea preprint server, involves the possibility that COVID-19 mRNA vaccines could trigger changes leading to oncogenesis. Led by Rachel Valdes Angues, a senior researcher and Post Doc at Oregon Health and Science University (OHSU), and researcher Yolanda Perea Bustos, the pair point to a hypothesis for COVID-19 vaccines and oncogenesis, also known as tumorigenesis or carcinogenesis, a phenomenon referring to the process by which normal cells are transformed into cancer cells. This process represents one that is complex, and multistep, one that involves various genetic, epigenetic, and environmental factors. Overall, oncogenesis leads to the development and progression of cancer. The pair express a disturbing hypothesis, one that’s based on reviews of the medical literature: that COVID-19 vaccines may predispose some cancer patients to cancer progression, recurrence, and/or metastasis.

The recent paper was submitted to Frontiers in Oncology. Interestingly, three of the reviewers endorsed the paper's publication yet the paper was rejected on “editorial grounds.” Does the topic raise an inconvenient topic? This manuscript has not been peer-reviewed and should not be cited as evidence. But TrialSite calls attention to the disturbing premise, one that should be further vetted.

What’s this hypothesis based on? According to the two authors whose paper was rejected for “editorial” reasons, they argue, “One that raises alarm of “biological plausibility (i.e., induction of lymphopenia and inflammation; downregulation of ACE2 expression; activation of oncogenic cascades; sequestration of tumor suppressor proteins; dysregulation of the G4-RNA-protein binding system and type I IFN responses; unsilencing of LINE-1 retrotransposons) together with growing anecdotal evidence and reports filed to Vaccine Adverse Effects Report System (VAERS) suggesting that some cancer patients experienced disease exacerbation or recurrence following COVID-19 vaccination. In light of the above, and because some of these concerns also apply to cancer patients infected with SARS-CoV-2, we encourage the scientific and medical community to urgently evaluate the impact of both COVID-19 and COVID-19 vaccination on cancer biology, adjusting public health recommendations accordingly.”

What is this hypothesis?

The pair hypothesize that “COVID-19 and/or certain COVID-19 vaccines generate a pro-tumorigenic milieu that predisposes some (stable) cancer patients and survivors to disease progression and/or (metastatic) recurrence.” Importantly, the vaccines covered in this hypothesis include those that “promote the endogenous production of SARS-CoV-2 spike (S) glycoprotein” including the two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) and the adenovirus-vectored vaccines (Johnson & Johnson and Oxford/AstraZeneca).

Limitations of this hypothesis

The authors to their credit acknowledge that studying the matter of COVID-19 and cancer, using VAERS and other sources remains a tricky research affair. It’s likely difficult to truly prove that COVID-19 vaccines induce cancer because of the “other clinical and social factors resulting from the 111 pandemic, such as adverse effects related to SARS-CoV-2 infection (29,30); steep declines in cancer 112 screening, diagnosis and treatment (31); adoption of unhealthy behaviors (i.e., increased alcohol 113 consumption, reduced physical activity) during long pandemic lockdowns (32); stress induced by the 114 COVID-19 crisis (33); and the assumption that millions of adults will remain unemployed and without health insurance; will independently contribute to cancer mortality in the months and years to come.”

Evidentiary Summary

The pair articulate that COVID-19 vaccine-based “SARS-CoV-2 spike glycoprotein-based vaccines, and particularly mRNA vaccines, can possibly initiate a set of biological mechanisms that could, in theory, “collectively generate a (transient) pro-tumorigenic environment favorable to cancer progression and/or reactivation of dormant cancer cells (DCCs).”

Such tragic adverse events would be “attributed to the pro-inflammatory action of the lipid nanoparticles (LNPs); the impaired type I interferon (IFN) response and/or translational dysregulation of cellular microRNAs triggered by structurally modified mRNA (mRNA vaccines); as well as to the unique nature, expression pattern, binding profile, and proinflammatory and tumorigenic effects of the produced antigens, namely the SARS-CoV-2 spike protein and/or its subunits S1 and S2 (mRNA and adenovirus-vectorized 127 vaccines).”

Biodistribution evidence points to the possibility at least in rare occasions of substantial levels of soluble spike and/or its subunits and peptide fragments in the circulation of vaccinees, possibly persisting for weeks, or even months.

Could it be the case that sustained and systemic distribution of spike within the human body promote a range of unforeseen interactions with angiotensin-converting enzyme 2 (ACE2), the entry receptor for SARS132 CoV-2, either in its soluble circulating form or expressed in cells from various tissues and organs? As part of this hypothesis, the authors point out that in most cases, the spike protein associated with the SARS-CoV-2 virus itself usually only impacts respiratory tract tissues and organs.


Children’s Health Defense Australia: saving our kids after Covid lockdowns

Julie Sladden

Few would disagree that the health of the children today foreshadows the health of the population tomorrow. With that in mind, the past three years of pandemic fear and dystopia have upset any preconceived ideas that the health of the people is on solid ground. In a worldwide response that saw nations lockdown, mask up, and mass vaccinate – ‘to protect grandma’ – it seems scant regard was paid to the cost incurred on the future generation.

Australia was ground zero for many of the more tyrannical restrictions of freedom and it didn’t go unnoticed. ‘The whole world is alarmed by what’s happening in Australia,’ said Robert F. Kennedy Jnr., founder of Children’s Health Defense US. With many states enforcing closed schools, masking of children, social distancing, and mandates, it will be years before the full impact of these actions is known.

As early data emerges on the impact on education, health, and social development it seems those who might pay the greatest price are the next generation. It is timely then that the Australian Chapter of the Children’s Health Defense was officially launched on August 26 this year.

With a board packed with expertise – Professor Robyn Cosford, Emeritus Professor Ramesh Thakur, lawyers Julian Gillespie and Peter Fam, Dr Astrid Lefringhausen, AMPS secretary and registered nurse Kara Thomas, and medical freedom advocate Cloi Geddes – Children’s Health Defense (CHD) Australia is well placed to bring light to, and stand against, the incursions on children’s health over the Covid years. But the story doesn’t begin there. The Covid response may simply be the catalyst, in Australia at least, for a light to be shone on the deterioration in the health of children over recent decades.

‘What we’re seeing in our children now … is an epidemic of chronic disease,’ explains Professor Cosford. ‘The sorts of things that we used to be seeing in older adults, in our grandparents, and our great aunts and uncles. We don’t expect to be seeing them in our children. We’re seeing an epidemic of immunological disorders where nearly half of the children have some kind of allergic-type disease, and we have autoimmune diseases occurring in our children which never have been seen before… We have an epidemic of mental health … (with) some 40 per cent (suffering) with depression, anxiety, OCD, panic disorders, and so on.’

‘And then there’s a big epidemic we’re seeing of neurodevelopmental disorders … one in ten diagnosed with ADHD, one in five with learning disorders, (and) one in 36 with autism. These (figures) have increased dramatically over the last 20-30 years and were unheard of before now.’

With a mission to ‘end childhood health epidemics’ the road ahead looks long. These alarming trends in the health of our children have been brewing for years and now may well have been exacerbated by the additional insult inflicted by the Covid response.

‘I ask as a grandparent: Why did we use children and adolescents as human shields to protect the supposed grown-ups and elderly?’ asks Ramesh Thakur, in his presentation titled Our Enemy the Government. ‘A major study recently concluded that lockdown harmed the emotional development of almost half of all British children.’ With lockdowns, closing of schools, restricted socialising, and masking it seems the price was paid by the young, who were least at risk, ‘…for a few more months of existing without living by the elderly most at risk,’ concludes Thakur.

More concerning and down-right disturbing, information is delivered during the launch by fellow presenters including the adverse effects of the Covid injections, censorship of free speech in science and medicine, DNA contamination in the Pfizer Covid injections, and legal cases in process which aim to protect our future generations.

Julian Gillespie described the heartache of ‘being belted by a judiciary that’s not acting like a judiciary’ in the recent AVN Babies case. Despite this, an unexpected benefit was the growth in support as the story spread around the nation.

‘Even though we didn’t get the correct and proper decision from the High Court, there was a massive outpouring of donors who told their friends who watched our videos with Maria Z, or Graham Hood, Health Alliance Australia, and AMPS. Parents would (start to) question (as) those videos… were pushed out across the country.’

Speaking to supporters Gillespie is clear, ‘It is correct to feel good that you participated. It did make a difference. You’ve enabled us to get the message out which is just the most important thing to allow the court of public opinion to make its mind up. (And) there are millions of us who can share the information and (help) save lives.’


Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH)

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs


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