Wednesday, December 14, 2022


DeSantis Announces Major Move Against COVID Vaccine Makers

Florida Republican Governor Ron DeSantis announced on Tuesday that he was seeking a grand jury investigation into the way COVID-19 vaccines were marketed and promoted and whether wrongdoing occurred.

"It is against the law to mislead and to misrepresent, particularly when you're talking about the efficacy of a drug," DeSantis said on Tuesday.

"Just recently, Florida got $3.2 billion through legal action against those responsible for the opioid crisis," he noted of previous legal action to hold drugmakers and drug sellers accountable. "It's not like this is something that is unprecedented," DeSantis said of his efforts to probe COVID-19 vaccines and the way they were presented to Floridians.

"Today, I'm announcing a petition with the Supreme Court of Florida to impanel a statewide grand jury to investigate any and all wrongdoing in Florida with respect to COVID-19 vaccines," DeSantis said.

"We anticipate that we will get the approval for that," DeSantis explained of his petition. The grand jury, DeSantis expects, "will be something that will be impaneled mostly likely in the Tampa Bay area."

DeSantis added that the grand jury "will come with legal processes that will be able to get more information" about any wrongdoing, and will "bring legal accountability for those who committed misconduct," he said.

The announcement on Tuesday is a follow-through on a promise Governor DeSantis made earlier in December when he pledged that his administration would "work to hold these manufacturers accountable for this mRNA [vaccine] because they said there was no side effects and we know that there have been a lot," DeSantis said of his plan to "bring some accountability" for COVID-19 vaccine makers, namely Pfizer and Moderna who produced the mRNA vaccines.

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Top Doctor: Long COVID is Being Exaggerated to Extort Taxpayers

John's Hopkins Medical School Professor Dr. Marty Makary, who also serves as a health advisor for Virginia Governor Glenn Youngkin, is warning "long COVID" is being exaggerated in order to extort American taxpayers for more money.

"Long Covid is real. I have reliable patients who describe lingering symptoms after Covid infection. But public-health officials have massively exaggerated long Covid to scare low-risk Americans as our government gives more than $1 billion to a long Covid medical-industrial complex," Makary writes in the Wall Street Journal.

"The National Institutes for Health has been intensely focused on studying long Covid, spending nearly $1.2 billion on the condition. To date, the return on investment has been zero for the people suffering with it. But it’s been terrific for MRI centers, lab testing companies and hospitals that set up long Covid clinics," he continues. "I’ve talked to the staff at some of these clinics and it’s unclear what they are actually offering to people beyond a myriad of tests."

The White House continues to demand endless funding as Dr. Anthony Fauci claims the U.S. is still "in the middle" of a pandemic.

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Michigan Medicine Prof. of Biologic Nanotechnology investigates Adverse Reactions Associated with COVID-19 mRNA Vaccines

The founding Director of the Mary H. Weiser Food Allergy Center, and Ruth Dow Doan Professor at Michigan Medicine not to mention an exceptional allergy and clinical immunology specialist, Dr. James Baker Jr., spearheads a 200-patient interventional study titled “Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction.” Launched in the spring, this single-group assignment open-label study runs till December 2024. In the study, the participant receives a dose of Pfizer-BioNTech (Comirnaty) or Moderna (Spikevax), both mRNA COVID-19 vaccines. The goal? Determine primary and secondary endpoints associated with safety of the mRNA-based vaccines. Specifically, the study team hypothesizes that the individuals that have had adverse reactions to a dose of an mRNA COVID-19 vaccine will tolerate an additional dose and those with a personal history of allergic reaction will tolerate vaccination with an mRNA COVID-19 vaccine.

While the U.S. Food and Drug Administration (FDA) has deemed the mRNA COVID-19 vaccines safe and effective, various side effects and adverse events have been identified, including in the regulatory package insert. For example, a cardiovascular signal has been identified in the form of myocarditis and pericarditis in young persons.

Can persons that had an adverse reaction to the first or second dose of either mRNA -based COVID-19 vaccine (Pfizer-BioNTech or Moderna) safely tolerate an additional dose if they have a personal history of allergic reaction who declined COVID-19 vaccination administration can safely tolerate an initial dose?

In this study funded by both the University of Michigan and the Wallace Foundation, Dr. Baker along with Dr. Charles Schuler IV, seek 200 eligible to receive an initial or additional dose of either Comirnaty or Spikevax.

Participants in this study will also be required to have 1-2 in person visits along with phone call follow up visits.

The study hypothesizes that individuals that have had adverse reactions to a dose of an mRNA COVID-19 vaccine will tolerate an additional dose, and those with a personal history of allergic reaction will tolerate vaccination with an mRNA COVID-19 vaccine.

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Pathological Syncytia Formation with mRNA Vaccines

One of the curious findings from the original randomized trials of mRNA vaccines was an explosive rate of early infection after the first injection as compared with placebo. In a recent paper from Sfera et al., the description of pathological syncytia or fusion between immune cells is described: “The LNP technology, to put it simply, mimics viral envelopes with externalized phosphatidylserine (ePS), a universal “eat me” signal, that directs immune cells to engulf the particle.

However, as ePS is also a potential “fuse me” signal, LNP may inadvertently facilitate the formation of pathological syncytia. Moreover, ePS may activate a disintegrin and metalloprotease 10 and 17 (ADAM10) (ADAM 17), master regulators of syncytia formation, contributing further to the unintended consequence of cell-cell fusion…As mRNA vaccines are based on pre-fusion epitopes, the fusion pathology may be undeterred, allowing viral infection by syncytia formation to continue unabated.

This is significant, as it could account for the reoccurrence of COVID-19 symptoms in fully vaccinated individuals. The authors point out that SARS-CoV-2 utilizes more than just the ACE2 receptor to gain entry into the fused cells and by overlooking this possibility, vaccine developers have made a blunder.

This is further complicated by the choice of lipid nanoparticles and polyethylene glycol which facilitate entry into organs were syncytia as well as Spike protein will incite inflammation and immune system regulation. Sfera also considers pregnancy: “Several studies demonstrated that SARS-CoV-2 can activate HERV-W, an ancestral gene that encodes for the physiological placental fusogen syncytin-1 responsible for the merger of trophoblasts during the early pregnancy. This suggests that the reproductive post-vaccine events may be triggered by the furin cleavage site pathology.” Such processes could occur in the gravid uterus and compound the bleeding and clotting risks of ill-advised vaccination is this special population.

In summary Sfera et al. point out the following blind spots of well-funded DARPA consultants, BARDA funded academic researchers, and later, by Pfizer and Moderna in mRNA vaccine development: 1) pathologic syncytia formation, 2) use of lipid nanoparticles with PEG, 3) failure to consider SARS-CoV-2 could use alternative points of cell entry other than ACE2 (metalloprotease pathway, antibody dependent enhancement, cell penetrating peptides, viroporins).

With billions of people rushed into indiscriminate mRNA vaccination, virologists and immunologists will be picking up the pieces of a failed vaccine campaign that has left so many at risk for more SARS-CoV-2 infections and progressive complications over the months and years to come.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Tuesday, December 13, 2022


Soft censorship of my Tongue Tied blog is now in place

Google has put the blog behind a scare warning. Free speech is dangerous in their view, apparently. I can't say I am surprised. They have done the same to my Political Correctness Watch blog.

I do however back the blog up elsewhere so readers who encounter the scare notice can go straight to the backup site if they wish. See here. I will upload to the backup site only minutes after the original site updates

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My other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com/ (AUSTRALIAN POLITICS)

http://dissectleft.blogspot.com (DISSECTING LEFTISM)

https://immigwatch.blogspot.com/ (IMMIGRATION WATCH)

https://awesternheart.blogspot.com/ (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Danish Study Published in Nature Reveals the Prejudice Unvaccinated Individuals Face in Most Countries

The results of a global study from Denmark’s Aarhus University, reveal that across the globe people show prejudice and discriminatory attitudes towards individuals not vaccinated against COVID-19. The findings have been published in the journal Nature.

The study is part of the research project How Democracies Cope with COVID-19: A Data-Driven Approach (HOPE), https://hope-project.dk/#/about supported by the Carlsberg Foundation. It was made in cooperation with the Centre for the Experimental-Philosophical Study of Discrimination, supported by the Danish National Research Foundation.

The researchers set out to assess whether people express discriminatory attitudes in family and political settings across groups defined by COVID-19 vaccination status. Specifically, the sought to quantify discriminatory attitudes between vaccinated and unvaccinated citizens in 21 countries, covering a diverse set of cultures across the world.

Across three conjoint experimental studies (N=15,233), researchers demonstrated that vaccinated people express discriminatory attitudes towards the unvaccinated, often as high as the discriminatory attitudes often seen in common targets including immigrants, drug-addicts and ex-convicts. In contrast, there was little evidence that unvaccinated individuals display discriminatory attitudes towards vaccinated people.

Many vaccinated people do not want close relatives to marry an unvaccinated person. They are also inclined to think that the unvaccinated are incompetent as well as untrustworthy, and they generally feel antipathy against them.

Discriminatory attitudes are more strongly expressed in cultures with stronger cooperative norms. According to the researchers, the reason for this appears to be that the vaccinated perceive the unvaccinated as free riders. The findings suggest that contributors to the public good of epidemic control (i.e., the vaccinated) react with discriminatory attitudes against perceived free-riders (i.e., the unvaccinated).

Part of the overall study looking solely in the United States showed that not only do vaccinated people harbor prejudice against the unvaccinated, but they also think they should be denied fundamental rights. For instance, the unvaccinated should not be allowed to move into the neighborhood or express their political views on social media freely, without fear of censorship.

“It is likely that we will encounter similar support for the restriction of rights in other countries, seeing as the prejudice and antipathy can be found across continents and cultures,” said co-author Michael Bang Petersen, who is a professor of political science at Aarhus University.

With low vaccine uptake still a challenge to pandemic management, the researchers warn authorities against employing a rhetoric of moral condemnation in their attempt increase vaccination rates.

“Moral condemnation may strengthen the cleavages and further feelings of exclusion that have led many unvaccinated to refuse the vaccine in the first place. Our prior research has shown that transparent communication about the safety and effectiveness of vaccines is a more viable public-health strategy for increasing vaccine uptake in the long term,” said Michael Bang Petersen.

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Molecular Changes linked to to Long COVID

One of the first studies of its kind, researchers at Mount Sinai in New York City associate long COVID symptoms with changes in gene expression during acute COVID-19. Specifically, researchers employed with this prestigious academic center in Manhattan are the first to publish a study associating changes in the blood gene expression during COVID-19 with post-acute sequelae of SARS-CoV-2 infection (long COVID) in patients over a year post hospitalization for severe COVID-19. Published in Nature Medicine on December 8, the team highlights the need for greater attention at the infection stage for improved understanding of how the processes that commence eventually turn into long COVID. The hope is that this research can help scientists better understand how the processes that start with SARS-CoV-2 infection led to long COVID. The goal? Develop prevention strategies and treatment options for COVID-19 survivors experiencing ongoing long COVID problems.

What did the Mount Sinai team discover?

Among other things, the New York City-based team found two molecularly distinct subsets of long COVID symptoms with opposing gene expression patterns during acute COVID-19 in plasma cells, the immune system’s antibody-producing cells.

In patients who went on to develop lung problems, antibody production genes were less abundant. However, for patients with other symptoms such as the loss of smell or taste and sleep disruptions, the same antibody production genes were more abundant instead.

Mount Sinai researchers led by co-corresponding author Noam D. Beckmann, Ph.D., Assistant Professor of Medicine (Data Driven and Digital Medicine) and Associate Director of Data Science Strategy at The Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai wrote that these opposing patterns observed in the same cells, as well as additional unique patterns observed in other cell types. They point to the existence of multiple independent processes leading to different long COVID symptoms; importantly, these processes are already present during acute infection.

Principal Investigator's Point of View

Dr. Beckmann went on the record “Our findings show that molecular processes leading to long COVID are already detectable during COVID-19 infection,” which of course has implications for future care regimens. The Mount Sinai professor continued, “Furthermore, we see the start of multiple molecularly distinct paths leading to long COVID, providing a unique viewpoint into differences between long-term symptoms.”

Study Data Sources

Using the Mount Sinai COVID-19 Biobank, the researchers examined gene expression data in blood samples from more than 500 patients hospitalized with COVID-19 between April and June 2020. More than 160 of these patients provided self-reported assessments of symptoms still present six months or more after hospitalization. The team tested each gene expressed in the blood for association with each long COVID symptom, accounting for ICU admission, COVID-19 severity during hospitalization, sex, age, and other variables. The team then tested for associations specific to each of 13 different types of immune cells, including plasma cells. Finally, these associations were categorized by whether they matched up with changes in patients’ levels of antibodies specific to the virus.

“For long COVID symptoms, like smell or taste problems, connecting antibody gene expression in plasma cells with the actual levels of antibodies against the SARS-CoV-2 spike protein demonstrates a direct link to the body’s response to the virus,” said lead author Ryan C. Thompson, Ph.D., Data Science Analyst at The Charles Bronfman Institute for Personalized Medicine. “On the other hand, the gene expression pattern for lung problems does not match up with SARS-CoV-2-specific antibody levels, highlighting the different immune processes leading to long COVID that are triggered by COVID-19.”

Long COVID Poorly Defined

The reality is that long COVID still remains poorly defined and future studies should take the initial stage of infection into account to characterize the molecular processes of long COVID more comprehensively and identify biomarkers that can help predict, treat, and prevent prolonged symptoms.

“Our findings show there is the potential to use data from the infection stage to predict what might happen to the patient months later,” said co-corresponding author Alexander W. Charney, MD, Ph.D., Associate Professor of Genetics and Genomic Sciences, and Co-Director of The Charles Bronfman Institute for Personalized Medicine. “We should not ignore the infection phase in research on long COVID—this is clearly a critical window of time where the body’s response to SARS-CoV-2 might be setting the stage for what is to come.”

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Exaggerated COVID-19 Death Rates used as Fright Factors

What did Emergency Use Authorizations (EUAs) do to lower the absolute risk of dying from COVID-19?

The phrases "fully vaccinated" and "fully antibody protected" mean different things, obviously. There is not a causation graph that proves that being "fully vaccinated" (a protocol of two shots, that is no longer a measure of efficacy or protection against newer SARS-CoV-2 variants) is any indication of Absolute Risk Reduction (ARR) from the risk of death from SARS-CoV-2. Since the original EUA products have diminishing benefits, the COVID-19 vaccination booster and bivalent booster rates are the only vaccination rates that should be considered to determine the ARR of deaths as a result of the COVID-19 variants of today. Even the nonvaccinated-person (as variable as this "group" is) COVID-19 death rates have changed.

There are hidden reasons for stories to come out the way they do. The recent stories that are being now told -- of achieving a universal saturation in humans of natural and injection-assisted antibodies to the variants of SARS-CoV-2 -- have many tangents. With these data from stories (clinical data are also the basis of "storytelling"), statisticians try to come up with one or two figures that represent statistics to comfort themselves with knowledge, such as how many individuals have died from COVID-19 -- 6,657,680 human deaths is a number that was published yesterday. But what do the statisticians' collective knowledge, represented by one figure, mean?

It means, for one thing, that only those official deaths, that were counted by official counters and recorded by official record keepers, that are the basis for COVID-19 policies and actions -- are not revealing everything we need to know. COVID-19 "death rates" are calculated for as many nations and geographic regions as can be officially monitored, but it is not now reasonable to call these numbers absolutely accurate figures.

Another confounding thing is that the number of deaths of individuals who were sometime-in-the-last-three-years infected with SARS-CoV-2 virus -- "had COVID-19" -- but were not only sick with COVID-19 (they were interfered with) -- having other added reasons that they died.

Yet another confounding factor to the official count is the number of deaths that occurred while attempting to mitigate the COVID-19 infections and contagion scope, with such actions "inadvertently leading to deaths of more individuals" than were in the death-by-COVID-19 designation (think: evasive tactics such as taking medications, receiving vaccinations, trying activities to avoid death from the virus, deaths at the hands of hospital staff, suicides, depression and personal abuses, etc.).

There are also the numbers of individuals that have not been revealed to the officials, those who have neither reported their SARS-CoV-2 infections, nor their recoveries, nor have their determined causes of deaths been clearly confirmed, nor has there been, or will be, a clear inventory of their virus-sharing contacts.

All these are confounding factors. This latter category -- 'contacts' -- is a juicy morsel of human geographical information, with absolute accuracy out of the reach of those demanding to convert us to that theory that the world surveillance of the human population would lower death rates.

But such a strained definition of correlation (of officials having knowledge of where we all are, what we own, what we spend, who we associate with -- correlated to our personal safety through submission to official policy) is a false authority attempt and an untenable conspiracy* that is yet currently being attempted by some so as to become centrally global in scope(if that ever made sense) -- just convince people to waive their own rights temporarily for "the sake of all". The COVID-19 death figure is to be your motivation to serve others in the way the government has found to be approved. Obey the mandates, lower the death rate -- is the mantra.

During this current COVID-19 disease period of changing variants, there is a current single figure representing the death rate from the disease called COVID-19, using one figure. This is supposed to scare us into giving our wills to a central organization that is planning to eradicate the disease COVID-19. We can admit that the figure is indicative of a large number of deaths, roughly calculated at 853.8 deaths of individual human beings -- per million population. With the starting point of "a nearly accurate population estimate" for the world of 8,002,627,404 live humans (the Current World Population from the Worldometers website at 0815 hours Mountain Standard Time on 12-10-2022), we can divide 6,657,680 (current official COVID-19 deaths) by 8,002,627,404 and then worry about how to stop that number from becoming a larger number:

It is not reasonable for the World Health Organization to consider being the One that is skilled and powerful -- so much so that it can attempt to persuade and/or mandate us all to a single-source treatment policy. It is advisory only, and advice can be and will be, in many cases in this vast world --- unuseable when that advice is also untenable.

The current conspiracy (or the milder tone of "collusion") to surveil and control our healthcare through the central organization WHO is untenable. The plans to convince us are dependent on waiving rights of masses of human populations in various and diverse countries.

There are 0.083194% of the World's Human Population that have officially died from COVID-19. Or for more clarity, the decimal fraction of the world's humans that have died from COVID-19, officially, is 0.000831937

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Monday, December 12, 2022




Pharmaceutical Trials: When Left’s Obsession With Race Kills

One of the last things Francis Collins, then-director of the National Institutes of Health, did before retiring was to pressure Moderna into delaying the release of its COVID-19 vaccine because he wanted more minorities in its clinical trials.

Moderna’s CEO, Stephane Bancel, was happy to oblige him, saying that diversity “matters more to us than speed.”

That decision was not based on science, and it likely cost lives. A new study by law professor Michael Conklin, and a new book by another law professor, David Bernstein, explain why.

The race labels that we are all familiar with—black, white, Asian, Hispanic, etc.—are not scientific. Quite the contrary, Bernstein traces their origins to “a combination of amateur anthropology and sociology, interest-group lobbying, incompetence, inertia, lack of public oversight, and happenstance.” They have no basis in biology, tell us nothing about genetics, and are therefore useless to medical research.

For that reason, when the federal government standardized our race labels in 1977, it said that they “should not be interpreted as being scientific or anthropological in nature.” Since then, scores of scholars and researchers have warned that our arbitrary labels should never be used in medical research.

But the bureaucrats at the Food and Drug Administration and National Institutes of Health, and the leadership of at least one of our major pharmaceutical companies, ignored them.

Conklin explains that “there is no statute or regulation that explicitly mandates pharmaceutical trials reach any racial quota among their study participants,” but the FDA requires companies to gather such data and “recommends” that they submit it when seeking approval for new medicines.

The FDA claims that “[e]nsuring people from diverse backgrounds join clinical trials is key to advancing health equity.” But, as any doctor or medical researcher who isn’t blinded by ideology will tell you, it isn’t.

Ideology, however, trumps science for many on the left.

Take Harvard Medical School professor Farrah Mateen, for example. In a 2021 paper, she called for racial quotas in medical trials to advance “health equity” even while admitting that “[r]ace is a social construct, a poorly defined marker of genetic diversity, and an imprecise proxy for the relationship between genetics and ancestry.”

In truth, our arbitrary race labels are utterly useless to the science of medicine, which needs to understand how drugs will react to biological and genetic traits.

To give an example of how useless race labels are for medical research, consider the category “black.” According to U.S. law, “black” is anyone descended from one of the black tribes of Africa. The race-obsessed, like Collins, Bancel, or Mateen, might think that this category tracks at least somewhat reliably with biological and genetic traits. After all, they might say, all these people trace their origin to one continent and share a skin color.

But the truth is that there is more genetic diversity among Africans than between other geographically organized people groups. In fact, there is more diversity among Africans than there is between Africans and Eurasians.

Genetic diversity is a lot more than skin color. Not that the race-obsessed care.

If our medical experts, bureaucrats, and drug manufacturers were interested in science, they wouldn’t use our arbitrary race labels in medical research. And if they cared about saving lives, they wouldn’t have delayed the rollout of a COVID-19 vaccine so that they could increase the color diversity of clinical trials.

But they weren’t interested in science, and they didn’t care about saving lives. At least, they didn’t care as much about those things as they cared about signaling their obedience to ideology.

People likely died because of Moderna’s decision to delay its vaccine. We’ll never know how many. But even if we did, it wouldn’t change these people’s behavior. Reality finds no purchase in the minds of the race-obsessed.

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Elon Musk Annihilates Two Leftist Shibboleths With A Single Five Word Tweet, And They Are Big Mad

It's no secret that billionaire Elon Musk has done nearly everything possible to rile up the political left since his purchase of Twitter finalized a month and a half ago, from freeing formerly frozen conservative accounts to releasing the Twitter Files detailing how previous management put their thumb on the scales to censor the right. However, a simple five-word tweet on Sunday morning may have finally driven them all insane permanently.

"My pronouns are Prosecute/Fauci," Musk wrote at 5:58 a.m. eastern time Sunday. So yeah, it was much earlier in Texas or California where Musk was likely located, because when has sleep - which the guy never does anyway - ever gotten in the way of an opportunity to massively troll the left?

If you're counting, that's two leftist shibboleths destroyed by Musk, a self-identified political centrist who believes in free speech. First, pronouns. Leftists love them some pronouns, especially ones that describe something different from someone's actual biological sex or are made up out of thin air. So, as actress Gina Carano found out the hard way, they get big mad when someone pokes fun at their new religion.

The other leftist shibboleth is, of course, America's Doctor Himself, Dr. Anthony Fauci, long may his name be blessed. While anyone with half a brain is at least questioning Fauci's approach to lockdowns, school closures, alternative Covid treatments, masks, and vaccine mandates as policies that resulted in massive suffering and death, leftists still revere the guy because he's one of them and they naturally agree with his totalitarian approach to tackling the pandemic.

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China’s dangerous zero-Covid retreat

China’s scrapping of strict Covid controls represents not so much a shift in gear, as a screeching hand-break turn. It is abrupt and haphazard and comes at a particularly risky time. Hundreds of millions of people will soon be on the move for Chinese New Year, which is next month, and the spread of the virus, already fast, will accelerate rapidly. The transition to living with Covid has not been easy for any country but will be particularly difficult for China – and dangerous for the communist party.

After almost three years of instilling fear – with brutal lockdowns, mass testing, sweeping quarantine and claustrophobic surveillance – the virus is suddenly being portrayed as quite benign

Only last month Xi Jinping was being portrayed as the commander in chief of a ‘people’s war’ against the virus. There was to be no turning back until it was defeated. In his address to the communist party congress Xi did not even note the enormous economic costs, the social toll and the mental stress he was imposing on China – and those brave enough to point them out were quickly silenced.

Now the very term ‘zero Covid’, used as a demonstration of party virility and a measure of superiority over bungling western democracies, has been eradicated from party propaganda. After almost three years of instilling fear – three years of at times brutal lockdowns, mass testing, sweeping quarantine and claustrophobic surveillance – the virus is suddenly being portrayed as quite benign. ‘Everyone should treat it with a normal heart – there is no need to be nervous or even fearful,’ declared Wang Guiqiang, director of the infectious diseases department at Peking University First Hospital.

In a review this week of China’s three-year fight against Covid, Xinhua, the state news agency, not only avoided any mention of contentious lockdowns, such as the two-month long shutdown of Shanghai earlier this year, but also made no mention of zero Covid – as if the policy had never existed. It was a rewriting of history, remarkable even by communist party standards. Thanks to party leadership, China had ‘survived the most difficult moment’, it insisted. Hysteric alarmism was replaced by what seems a remarkable complacency, given the challenges China still faces.

When China’s National Health Commission said this week that it was dropping many of its quarantine and mass testing measures, and that it would reduce the use of lockdowns, it presented the change as a logical response to the changing nature of the threat. But the party does not do logical. Its principal concerns will have been the mounting damage to the economy and the wave of unrest that has swept China.

It has been reported that Xi was swayed by a letter sent by Terry Gou, the head of Foxconn, which assembles most of the world’s iPhones for Apple. Its vast factory complex in Zhengzhou was the scene last month of large-scale rioting. Gou warned Xi that strict Covid controls threatened China’s central position in global supply chains. That may well have had some influence, but more likely the trigger for easing restrictions was the often-violent protests against zero Covid that swept across China. They shook the party leadership because they were so geographically widespread and involved a broad range of social groups from migrant and factory workers to students and the urban elite. It was not so easy to blame the unrest on the usual foreign ‘dark hand’ or other ‘bad elements’ – it was an expression of popular anger and frustration, and it targeted Xi and the party.

The party does not do admissions of failure, although that is what its easing of controls amounts to. The country is ill-prepared for the sudden switch away from Xi’s zero-Covid dogmatism. A vast bureaucracy and industry has been built to impose Xi’s will and to fight his fight – as represented by the massed ranks of white hazmat-suited enforcers. But they have not put in place the basic tools needed to live with the virus. Only two thirds of those aged 80 and over, the most vulnerable to serious illness or death, have received the initial course of vaccination, usually two shots, and only two-fifths of this age group have had a booster. Chinese vaccines are less effective than their western counterparts, especially against the latest Omicron variants, and Xi has stubbornly refused to allow the import of foreign jabs. There is also little natural immunity, since most people have until now been shielded from the virus. According to government statistics, China has 3.6 intensive care beds per 100,000 people, compared to 29.4 in the United States and a little over seven in the UK.

The healthcare system could be quickly overwhelmed, and modelling of the likely impact does not make for comfortable reading for healthcare workers – or the party. Up to a million people are at risk of dying in a ‘winter wave’ of Covid, according to projections reported by the Financial Times. Figures from Wigram Capital Advisors, which provided modelling to governments during the pandemic, suggest the number of deaths could reach 20,000 a day by mid-March, with the demand for critical care beds peaking at ten times capacity.

Chinese New Year falls on 22 January – the year of the Rabbit. In any usual year the annual holiday sees the world’s largest migration of people, with perhaps 400 million on the move. This time could be even busier with considerable pent-up demand for travel and a hunger to see loved ones after years of restrictions. Not only does it stand to be a ‘super-spreader’ event, but inadequately prepared rural areas could be overwhelmed by the virus.

After their initial euphoria, financial markets have become much more cautious. The economy is unlikely to quickly bounce back. Few people are ruling out an abrupt reversal by the party, imposing travel restrictions or even more severe lockdowns if there is an explosion in the number of cases. But the rapid return of the zero-Covid straight-jacket could in turn trigger more unrest among a population emboldened by what is seen widely as the success of their protests in forcing rare concessions from the party.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Sunday, December 11, 2022



FDA Says Ivermectin Doesn’t Work Against COVID-19 but Points to Studies That Show It Does

The FDA’s website states, “Currently available data do not show ivermectin is effective against COVID-19.”

But half of the studies to which the FDA points support using ivermectin against COVID-19, according to the review.

The papers cut against the drug agency’s repeated exhortations for people not to take ivermectin for COVID-19. In Twitter posts, public statements, and emails, FDA officials have repeatedly warned against ivermectin. Some of those statements triggered a lawsuit from doctors who say the agency’s role is to approve drugs, not to issue recommendations. The suit was dismissed this week.

Dr. Pierre Kory, who frequently prescribes ivermectin for COVID-19 and co-authored a meta-analysis that concluded the drug is effective against the illness, told The Epoch Times that the government’s position on ivermectin “is one of the most glaring examples of the corruption of modern evidence based medicine.”

“There’s one message they want everyone to understand. And that message is that ivermectin doesn’t work,” Kory said. “That’s not a scientific conclusion, that’s theirs. That’s their perverted and distorted interpretation of the data.”

The FDA’s media office did not respond to a request for comment.

Dr. Janet Woodcock, a top official at the agency who was its commissioner from January 2021 to February 2022, told The Epoch Times via email that “ivermectin has been shown to be ineffective against COVID in large randomized trials.”

Studies

The FDA’s website points to a U.S. National Library of Medicine database of studies analyzing ivermectin against COVID-19. There are 88 studies listed in the database.

Out of studies that are listed, have been completed, and have results reported, half show or indicate ivermectin effectively combats or prevents COVID-19, according to the review by The Epoch Times.

They include papers reporting on results from randomized, controlled trials, which are often offered as the highest level of evidence by U.S. government officials. Such trials feature a group that receives a placebo and a group that receives the drug, randomization into groups, and blinding, or shielding operators and/or patients from the knowledge of which participants are receiving ivermectin.

Among the papers is a randomized, blinded, controlled trial that found people who received ivermectin and doxycycline, an antibiotic, recovered faster from COVID-19 than those who received a placebo.

Bangladeshi researchers reported the results from the trial of 363 participants on May 13, 2021, in the Journal of International Medical Research.

“Patients with mild-to-moderate COVID-19 infection treated with ivermectin plus doxycycline recovered earlier, were less likely to progress to more serious disease, and were more likely to be COVID-19 negative by RT-PCR on day 14,” they said. PCR has been used to test for COVID-19.

Another paper, published on July 7, 2022, in the International Journal of Infectious Diseases, found that that ivermectin decreased the level of COVID-19 and its viability. Israeli researchers in the randomized, controlled, open label trial compared 47 patients who received ivermectin against 42 who received placebos and said that “ivermectin significantly reduced the time of viral shedding and affected viral viability when initiated in the first week after evidence of infection.”

“There were lower viral loads and less viable cultures in the ivermectin group, which shows its anti-SARS-CoV-2 activity,” the researchers said. SARS-CoV-2 is a name for the virus that causes COVID-19.

A third paper concluded that a regimen of ivermectin and carrageenan works as a prophylaxis, or preventative medicine. Argentinian researchers found in the observational trial involving 229 health care workers that ivermectin helped prevent COVID-19 infection. A followup study involving nearly 1,200 workers confirmed the results. Both sets were reported in the Journal of Clinical and Biomedical Investigation on Nov. 17, 2020.

Ivermectin “could have saved so many lives,” Héctor Carvallo, one of the researchers, told The Epoch Times via email, adding that “it’s been a crime against mankind to prevent its prescription.”

Some other studies, including the largest ones, either found indications that ivermectin works against COVID-19 but did not achieve statistical significance or found no evidence that ivermectin is effective.

That includes a randomized, controlled, double-blind 2021 study by Mexican researchers that found ivermectin did not significantly impact hospitalization duration or mortality, and a randomized, controlled, double-blind 2022 trial by U.S. researchers that concluded ivermectin did not prevent hypoxemia, hospitalization, or death.

FDA Intervention

Scientists in Australia in April 2020 found that ivermectin worked well against the COVID-19 virus in cell culture, prompting doctors in multiple countries, including Peru and the United States, to start using it against the new illness.

Ivermectin is approved by the FDA to treat parasites. One version is used on horses and other animals.

The FDA quickly warned against using the animal form and said that people should “not take any form of ivermectin unless it has been prescribed to them by a licensed health care provider and is obtained through a legitimate source.”

Studies later in the year suggested ivermectin worked well in humans who had COVID-19, including halting the progression of disease (pdf), helping patients improve faster, and preventing COVID-19 infection, though other studies returned results that did not support ivermectin as a treatment.

The FDA maintained its stance against COVID-19, and created a new web page on March 5, 2021. It initially said, “The FDA has not reviewed data to support use of ivermectin in COVID-19 patients to treat or to prevent COVID-19; however, some initial research is underway.”

In August 2021, the FDA urged people against using ivermectin by telling them that “you are not a horse.” It linked to the page, which was updated the following month with the language it now contains about data not showing ivermectin is effective.

American doctors are allowed to prescribe drugs approved for one use for a different use, a practice known as off-label. But doctors who prescribed ivermectin soon found that many pharmacies stopped filling prescriptions, citing advice from the FDA and other U.S. government bodies.

Half of Studies Supportive

The FDA does not cite studies on its website to support its statement that data “do not show ivermectin is effective against COVID-19.”

“Clinical trials assessing ivermectin tablets for the prevention or treatment of COVID-19 in people are ongoing,” the agency adds, providing a link to the U.S. National Library of Medicine’s database.

Of the 88 studies listed there, 56 fall under one of three categories: have not been completed, were completed but results have not been reported, or were completed and have since been retracted or otherwise withdrawn.

Of the remaining 32, 16 found or indicate ivermectin is effective as a COVID-19 treatment or prophylactic, according to the Epoch Times review.

Two of the trials were randomized, controlled, and blinded. Nine others were randomized and controlled but were not blinded at all. Most of the rest were observational, meaning they analyzed data from real-world settings like hospitals, or used observational data to create what’s known as a synthetic control group.

The set of papers includes results of a randomized, controlled, open label observational trial (pdf) that found ivermectin combined with doxycycline, an antibiotic, reduced the time to recovery and the mortality rate, and a randomized, controlled, double-blinded trial that found ivermectin and doxycycline quickened recovery and patients were less likely to see their disease progress.

Of the 16 other studies, six reported mixed results. For instance, Spanish researchers reported in The Lancet in February 2021 that ivermectin did not have an impact on testing results, but that there was “a marked reduction” of self-reported symptoms such as loss of smell and cough, and lower levels of viral loads. The result “warrants assessment in larger trials,” the researchers said.

The remaining 10 studies returned results that did not favor ivermectin or did not achieve statistical significance.

U.S. researchers, for example, found that ivermectin probably worked better than a placebo, but that the results did not achieve statistical significance, prompting them to say in October that “this study adds to the growing evidence that there is not a clinically relevant treatment effect of ivermectin at this dose and duration.”

The FDA did not respond to a request for comment on the revelation that half of the studies it points to support using ivermectin (IVM) against COVID-19.

Woodcock, the FDA’s principal deputy commissioner, reviewed the studies. She was unimpressed.

The Bangladeshi trial, for instance, was criticized for primarily including young persons, and having a higher number of dropouts in the placebo arm. Woodcock said the Israeli study did not report “clinical outcomes” and noted many of the other papers had small numbers of participants.

“There are only a couple studies here that really look at the effects of IVM and see a positive clinical effect and they are much smaller than the negative studies,” Woodcock told The Epoch Times in an email.

The trials in favor of ivermectin are on the smaller side, and more likely to be observational. But that doesn’t necessarily mean they are inferior, Kory said. He cited research that found there was little difference between observational studies and randomized-controlled trials, as well as a paper that said “study design is only one factor that determines study quality.”

The FDA isn’t the only government group opposed to using ivermectin to treat COVID-19. The National Institutes of Health (NIH) COVID-19 Treatment Guidelines Panel recommends against it, citing several of the larger trials that found little or no benefit for ivermectin. The panel cites none of the papers that found a positive effect.

Criticism of Design

Many of those studies have been criticized over their design. One major factor, critics say, is participants not receiving ivermectin soon after a positive test or the start of symptoms.

In one trial, researchers acknowledged that more than 4 out of 10 participants did not receive the dosage level that was listed as the “goal dose.” Further, the median time from the start of symptoms to treatment was six days, and the treatment duration was just three days. The trial, called ACTIV-6, was backed by the NIH.

The corresponding author for the trial did not return a request for comment. The authors said that “there was no evidence of a differential treatment effect based on the median time of symptom onset to receipt of study drug.”

In another trial that reported little difference between the treatment and control groups, the treatment group received ivermectin days after starting to show symptoms.

Ivermectin works best when applied within 24 hours of symptom manifestation, according to a meta regression of ivermectin studies performed by by an unnamed group of researchers.

“They literally try to treat as late into the disease as they can, for a short duration as they can, at the lowest dose that they can. And they also try to find as healthy and mild patients as you can,” Kory said.

“And yet, when they conduct those kinds of trials, it’s on the front page of a high-impact journal and the conclusion states, ‘this shows there’s no role for ivermectin in treatments.’ Absolutely absurd. And so it’s it’s really just corruption of these trials.”

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Friday, December 09, 2022


Covid jab resisters are seen as 'incompetent, untrustworthy' and not marriage material - study reveals

I don't share that view. I reluctantly had two shots but I am perfectly happy that my girlfriend is an ardent anti-vaxxer

A huge global study has revealed the emergence of Covid vaccine snobbery, with vaccinated people seeing the unvaccinated as 'incompetent, untrustworthy' and even poor marriage material.

The study of 15,233 people from 21 countries, including Australia, found vaccinated people were more discriminatory about the unvaccinated than they were towards ex-criminals and drug addicts.

The study, led by Denmark's Aarhus University, also showed the vaccinated generally hold more strongly negative attitudes towards unvaccinated individuals than the other way around.

Its authors claim vaccinated people were 'motivated to exclude the unvaccinated from family relationships and even protected political rights'.

They did however note the reaction was understandable because of the importance of widespread vaccination.

But they also advised governments to take urgent steps to heal the wounds caused by discrimination on the basis of vaccination status during the pandemic.

The study did not include any findings on attitudes about the effectiveness of vaccines, which were estimated to have saved millions of lives.

In June 2022, the highly respected Lancet medical journal estimated that vaccinations prevented up to 20 million deaths from Covid in 185 countries between December 2020 and December 2021.

But the new study's results cast previously unpopular defences of the unvaccinated in a completely new light.

Those include Scott Morrison's call in November 2021 that the unvaccinated should be allowed to order a cup of coffee if they want one - which was criticised by Queensland premier Annastacia Palaszczuk.

The survey also appears to at least partly support claims by fringe politicians and protest groups that discrimination against unvaccinated people was a real thing in Australia.

One Nation leader Pauline Hanson's efforts to introduce her controversial Covid-19 Vaccination Status (Prevention of Discrimination) Bill in November 2021 to federal parliament were defeated.

Covid vaccinations commenced in Australia in February 2021.

As of December 7, 2022, more than 64 million doses of Covid vaccines have been administered in Australia, and 96 per cent of Australians have had at least two doses.

An estimated 500,000 Australians remain unvaccinated, with their reasons a mix of fears about potential health impacts and a personal stand against vaccine mandates.

The 'discrimination' against unvaccinated people worldwide is so serious that study's authors 'urge authorities across the world to heal the cleavages in society left by the Covid-19 pandemic'.

'The study shows that prejudice towards the unvaccinated is as high or higher than prejudice directed towards other common and diverse targets of prejudice, including immigrants, drug-addicts and ex-convicts,' the authors wrote.

'In contrast, researchers find that the unvaccinated display almost no discriminatory attitudes towards the vaccinated.'

The findings directly contradict a public perception that 'anti-vax' and so-called 'freedom' protesters were antagonistic towards vaccinated people.

They also further strengthen the claims that Australian state governments overreached with tough Covid public health orders - such as thousands of fines, which were recently ruled invalid.

The study, titled Discriminatory Attitudes Against the Unvaccinated During a Global Pandemic, was authored by post-doctorate student Alexander Bor and Michael Bang Petersen, a professor of political science.

The data was collected from 21 countries - including Australia - between December 3, 2021 and January 28, 2022.

The global study involved picking 500 respondents each from Australia, Brazil, Denmark, France, Germany, Italy, Mexico, Russia, Spain, Britain, and the United States.

At the time, Sydney and Melbourne were in the grips of an Omicron outbreak, interrupting Christmas plans for millions of frustrated people who had taken up vaccinations.

Queensland's case numbers were just beginning to take off.

The study revealed attitudes 'in all inhabited continents' towards the unvaccinated were so extreme that many vaccinated people 'do not want close relatives to marry an unvaccinated person'.

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Military background of the Covid vaccines explains a lot

Like blurry shapes in a swirling kaleidoscope that suddenly stops, three critical pieces of the pandemic puzzle came into focus this week.

First is the publication on 6 December of an explosive account of The Truth about Wuhan by Dr Andrew Huff, former vice president, from 2014 to 2016, of the EcoHealth Alliance (EA), the dodgy New York-based not-for-profit that funnelled millions of dollars from the US Department of Defense and Dr Fauci’s National Institute of Allergies and Infectious Diseases to the Wuhan Institute of Virology (WIV).

Huff is a highly credentialed whistleblower, who served in Iraq, has a Masters in security technology, and a doctorate in bioterrorism. He was shocked when he saw that the EcoHealth Alliance was transferring gain-of-function techniques to Chinese scientists at the WIV allowing them to make dangerous viruses more infectious and says Sars-CoV-2 was developed during his time at the organisation.

This is supported by Peter Daszak, founder of the EA who boasted in 2016 in a speech to the New York Academy of Medicine presciently titled ‘History and Future of Pandemics’, that he and his colleagues at the WIV had sequenced the spike protein of Sars-like bat coronaviruses and inserted them into pseudo particles to ‘see if they bind to human cells’, observing that with each step they moved closer and closer to a virus that could ‘really become pathogenic in people’.

Amongst those who attended Daszak’s speech was Ian Lipkin, professor of epidemiology at Columbia University and one of the authors of the infamous paper, ‘The Proximal Origin of Sars-CoV-2’. Unredacted emails released in the last fortnight show that the paper was written at the behest of Fauci to rubbish the idea that the virus could have been created in a lab and smear anyone who said otherwise as a crackpot conspiracy theorist. Yet the emails show all the authors knew that the virus could be made more infectious in a lab. Despite – or perhaps because – Daszak refuses to disclose the specific virus that the WIV enhanced, Fauci has continued to fund the EA during the pandemic to the tune of nearly $7 million.

Huff says he sounded the alarm over biosecurity risks at the WIV because of its lax lab management and resigned in 2016 because of ethical concerns with the organisation. But in late 2019 he was offered a job at the US Defense Advanced Research Projects Agency (DARPA). He thinks DARPA already knew about the lab leak and wanted him inside the tent to make sure he couldn’t speak out as they embarked on a massive cover-up of their role in funding the creation of Sars-CoV-2. When he spoke out, he says he was subjected to extraordinary harassment including being stalked by military-grade drones. While China can be expected to lie about the pandemic, Huff’s account explains why Fauci and the Department of Defense would be so keen to cover up what happened in Wuhan.

The third piece of the puzzle to emerge in the last week is provided by Sasha Latypova, a pharmaceutical insider who worked in clinical trials for 25 years. She brings an insider’s focus to a key feature of the response to the pandemic that was hiding in plain sight. The development of the Covid vaccines was undertaken within the framework of the US government’s bioterrorism program under the aegis of the National Security Council.

The diabolical predicament in which we find ourselves is that Operation Warp Speed and its successor under President Biden, was run, at the highest levels, by the military not by vaccine developers, and the products are deemed to be military medical countermeasures. As a result, those in charge of producing them are also charged with regulating their safety and efficacy which they are not required to prove to anyone. They do this under the Emergency Use Authorisation Act (1997) which allows the Department of Health and Human Services (HHS) to dispense with normal safety and efficacy regulations in a public health emergency, if no other effective treatment exists. This provides an important incentive to disregard existing medication to treat Covid or to damn it as ineffective. It also explains why the more than 32,500 deaths and 1.47 million injuries which have been reported to the US database of Covid Vaccine Adverse Events through to 25 November, more than for any vaccine in history, can be ignored when other vaccine rollouts have been halted after 50 deaths.

HHS is also empowered under the Other Transactions Authority Act (2015) to order undisclosed medical countermeasures from pharmaceutical companies without being subject to any scrutiny. Likewise, the companies are not obliged to share the intellectual property developed with taxpayer funds with the government. Millions of dollars can be channelled to companies who can reward government officials with well-remunerated jobs in the private sector in a constant revolving door. It also means pharmaceutical companies have not had to detail to regulators the content of, for example, their proprietary lipid nanoparticles, or tests to prove what they are, what they do, and how they can be consistently manufactured. Indeed, the failure of contractors to comply with standard good manufacturing practices has been disregarded.

Finally, under the PREP Act the Public Health Emergency Declaration of 2020 exempts anyone acting within the framework of the Act from any liability for any injury or death for as long as their is a ‘public health emergency’, which no doubt explains why President Biden recently renewed the emergency declaration.

Without anyone to hold anyone to account, the US government and the vast majority of governments around the world, including ours, have showered billions of dollars on the manufacturers of the most lethal vaccines ever created. Big Pharma hasn’t captured the regulator, the Department of Defense has captured Big Pharma in a mutually rewarding deadly embrace.

For us, however, like Pandora, there is no way out of our dilemma. All that we have left is hope that those who, like gods, have been given unlimited power might give it way, a hope which as Friedrich Nietzsche argued may be ‘the most evil of evils because it prolongs man’s torment’.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Thursday, December 08, 2022


Here Is How the FDA Made the RSV Wave More Dangerous

Forget Covid-19 and Monkeypox. Respiratory syncytial virus (often shortened to RSV) may be the biggest public health threat this season. RSV is a virus that often results in mild cold-like symptoms for many infected adults. However, it can be deadly for children. RSV is estimated to be responsible for 1 out of 50 children’s deaths globally and 1 out of 56 deaths for children in developed countries.

RSV is rapidly spreading across the US and threatens our youth. The Center for Infectious Disease Research and Policy at the University of Minnesota reports the highest hospitalization rates for flu (including RSV) in a decade—with children and seniors most affected. California recently reported its first RSV complications-related death for a child. Fearing the worst is yet to come, Colorado Governor Jared Polis signed an order extending the Covid-19 emergency declaration to include RSV and other respiratory viruses. Governors in other states could follow his lead.

The younger the patient, the more difficult RSV is to treat. Infants with RSV cannot safely use most medications to treat the virus’s symptoms. Because infants are particularly susceptible to developing bronchitis or pneumonia from RSV, carefully monitoring breathing patterns is vital.

There are very few devices that effectively monitor an infant’s oxygen levels, and many of them are only found in hospitals. There used to be one widely available to parents until the Food and Drug Administration ordered it off the market.

Nearly a year ago, the FDA sent a warning letter to Owlet regarding its Smart Sock—a product that monitored an infant’s pulse and oxygen intake. The letter stated the FDA determined the Smart Sock is a medical device that needed to undergo the agency’s approval process before reaching the market. At the time, Smart Socks had been on the market for five years, boasted a 90 percent accuracy rating according to peer-reviewed research, and helped over 600,000 parents care for their children.

Unable to undergo the time-consuming and expensive process, Owlet released a version of the Smart Sock this January. But the latest version no longer monitors an infant’s heart or lungs. Consequently, the FDA drove parents’ best option to carefully monitor their baby’s vital organ function off the market.

In an article I wrote for the American Institute for Economic Research shortly before the Smart Sock was pulled from store shelves, I warned, “The cost of the agency’s decision is hundreds of thousands of infants going without a highly reliable monitoring device and countless sleepless nights for parents fearing for their children’s health or life.” As RSV sweeps across the country, there will be tragically more of both.

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Could COVID hold key to curing cancer? Virus' notorious spike protein kills hard-to-treat lung tumors in lab studies

The virus has claimed the lives of six million people and caused unprecedented global disruption — but Covid might actually hold clues to curing cancer.

In lab studies, a modified version of Covid's spike protein killed the most treatment-resistant and deadliest form of lung cancer.

The spike protein is the unique part of Covid that is used to infect people as it is the structure that binds to human cells in the first instance.

It could also infect and kill lung cancer cells, as when combined with other cells, the protein can set in motion the process of cells dying.

Kalipada Pahan, professor of neurology at RUSH Medical College in Chicago and lead investigator of the study, said: 'If these results are replicated in lung cancer patients, it would uncover a promising avenue of this devastating disease.

'Intranasal spike S1 protein could be used for late-stage lung cancer when there’s no other therapy to stop the progression.'

The researchers said there have been anecdotal cases of people with lung cancer whose conditions improved after being infected with Covid, which bolsters their theory.

In the study, published in the journal Cancers, the team took a cloned version of the spike protein that is available to buy for scientists.

They then exposed it to non-small cell lung cancer cells from humans in a petri dish. They found that when the protein was added, it sparked the death of the cancer cells.

Next they gave the protein to the mice with established lung cancer by spraying it up their nose every other day, and gave another group of mice a saline solution as a control.

After four weeks, they examined the mice's tumors and found that the number and size of tumors had decreased in the group given the Covid spike.

Lung cancer is the main cause of cancer related deaths in the world, and has quite a low five-year survival rate.

Rates have not improved despite a multitude of therapies for lung cancer.

According to the American Cancer Society, there will be around 236,740 new cases of lung cancer in this year alone.

Non-small cell lung cancer makes up around 84 percent of all lung cancers, found a study.

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Sex, Racial, and Ethnic Representation in COVID-19 Clinical Trials. A Systematic Review and Meta-analysis

Hong Xiao et al.

Key Points

Question: Compared with their representation in the US population with COVID-19, are female participants and racial and ethnic minority persons underenrolled in COVID-19 prevention and treatment trials?

Findings: In this systematic review and meta-analysis of 122 US-based COVID-19 clinical trials with 176 654 participants, female participants were underrepresented in treatment trials, Asian and Black participants were underrepresented in prevention trials, and Hispanic or Latino participants were overrepresented in treatment trials.

Meaning: These findings show systemwide differences in representation for several key demographic groups in COVID-19 prevention and treatment trials in the US.

Abstract

Importance: Since the onset of the COVID-19 pandemic, there have been calls for COVID-19 clinical trials to be fully representative of all demographic groups. However, limited evidence is available about the sex, racial, and ethnic representation among COVID-19 prevention and treatment trials.

Objective: To investigate whether female participants and racial and ethnic minority individuals are adequately represented in COVID-19 prevention and treatment trials in the US.

Data Sources: Identified studies were registered on ClinicalTrials.gov or published in the PubMed database from October 2019 to February 2022.

Study Selection: Included studies must have provided the number of enrolled participants by sex, race, or ethnicity. Only interventional studies conducted in the US for the primary purpose of the diagnosis, prevention, or treatment of (or supportive care for) COVID-19 conditions were included.

Data Extraction and Synthesis: Data on counts of enrollments by demographic variables (sex, race, and ethnicity) and location (country and state) were abstracted. Studies were broadly categorized by primary purpose as prevention (including vaccine and diagnosis studies) vs treatment (including supportive care studies). A random effects model for single proportions was used. Trial estimates were compared with corresponding estimates of representation in the US population with COVID-19.

Main Outcomes and Measures: Sex, racial, and ethnic representation in COVID-19 clinical trials compared with their representation in the US population with COVID-19.

Results: Overall, 122 US-based COVID-19 clinical trials comprising 176 654 participants were analyzed. Studies were predominantly randomized trials (n = 95) for treatment of COVID-19 (n = 103). Sex, race, and ethnicity were reported in 109 (89.3%), 95 (77.9%), and 87 (71.3%) trials, respectively. Estimated representation in prevention and treatment trials vs the US population with COVID-19 was 48.9% and 44.6% vs 52.4% for female participants; 23.0% and 36.6% vs 17.7% for Hispanic or Latino participants; 7.2% and 16.5% vs 14.1% for Black participants; 3.8% and 4.6% vs 3.7% for Asian participants; 0.2% and 0.9% vs 0.2% for Native Hawaiian or Other Pacific Islander participants; and 1.3% and 1.4% vs 1.1% for American Indian or Alaska Native participants. Compared with expected rates in the COVID-19 reference population, female participants were underrepresented in treatment trials (85.1% of expected; P < .001), Black participants (53.7% of expected; P = .003) and Asian participants (64.4% of expected; P = .003) were underrepresented in prevention trials, and Hispanic or Latino participants were overrepresented in treatment trials (206.8% of expected; P < .001).

Conclusions and Relevance: In this systematic review and meta-analysis, aggregate differences in representation for several demographic groups in COVID-19 prevention and treatment trials in the US were found.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH) Also here

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH) Also here

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Wednesday, December 07, 2022


Victory for lockdown opponent

Governor Kemp credits consistent, good management for his 8-point victory over his Democratic opponent, Stacey Abrams in their second matchup for the Georgia chief executive office.

In the end, Mr. Kemp was done in neither by the fierce national media criticisms of how he handled Covid, the corporate meltdown over the state’s new voting laws, the massive resources that poured in for Ms. Abrams, nor even by former President Trump’s strident campaign against him in the state’s primary.

“We just had a great record to run on, which obviously I didn’t have last time,” he told the Washington Examiner in an interview. When he ran in 2018, he was only the secretary of state. This time, his record included tax cuts, teacher pay raises and an economy less damaged by Covid than those of many other states.

At a time when Mr. Trump’s word was often golden in so many states’ Republican primaries, Mr. Kemp not only defeated but in fact clobbered his Trump-backed Republican primary opponent, Senator Perdue, by 50 points.

“I told our folks going into the primary, ‘We have a record to run on offensively in this campaign and I don’t ever want to be on the defensive; I want to take the fight to David Perdue and I want to take the fight to Stacey Abrams,’” he explained.

“And that’s what we did. And if you really look back, I think our team did a really good job of keeping them on their heels and keeping things focused on what we were; we never allowed anybody to get us in the weeds on all this other stuff.”

He added: “And we just ignored all the outside noise; stuff she was pushing, stuff the Left was pushing, stuff that President Trump or whoever may have been pushing.”

Mr. Kemp credits how he has handled tough times, both campaigns and outside forces, as moments that paved the way and prepared him for this year. “Ever since I got elected in ‘18, the likelihood of us having a rematch was going to be there,” he said.

“So, we developed our own ground game, our own, really, operation to get the vote out, to go after low propensity voters and swing voters and offered them a message of hope and prosperity that appealed to them.”

Mr. Kemp said he was prepared to be outspent but knew that his team had offered an argument to voters, something for them to vote for and not against, and it served his party well.

“We won every single other constitutional office, and we had a good night with our legislative candidates as well, and we got Herschel (Walker) in a runoff with Warnock,” he said.

“It’s tough beating an incumbent, but anytime you got an incumbent in a runoff in Georgia, there’s an opportunity to knock them off.”

Mr. Kemp went into his first race for governor against Ms. Abrams in 2018 as the underdog, with her as the superstar who ran on becoming the nation’s first black female governor. She failed, but the media favorably covered her high-profile denial of the election result and spurious claims of mass voter disenfranchisement.

Within two years, many outlets were already writing Mr. Kemp's political obituary when he became the target of Mr. Trump’s wrath. Mr. Kemp had enraged Mr. Trump by certifying President Biden’s victorious slate of presidential electors in Georgia.

A few months later, he faced a different form of wrath from Mr. Biden, corporate America and every other news organization in America. They were falsely calling the state’s new voting reform law “Jim Crow 2.0,” even though most of them hadn't even bothered to skim the legislation — they just took Democrats’ word for it.

Major League Baseball went so far as to move the All-Star Game out of the state. As he did then, Mr. Kemp shrugs. “Two of the largest investment companies in the state, Delta Air Lines and Coca-Cola, really were the ones that started that,” he said of the allegations the voting law would somehow suppress minority vote, “and then obviously Major League Baseball piled on.”

He added that “we had a lot we had to stand up to and push through. But I think when we did that, I stayed really focused on what our people wanted, not what the political pressure and a few people wanted.”

He also didn’t cave under political pressure when he was the first to reopen small parts of the economy during the pandemic — after the first wave of “stop the spread” and “flatten the curve” passed.

“Of the governors that were doing that at that time, I took obviously the most grief,” he said. “At one time, every state around us had their state parks closed or some of their beaches closed, and we never did that,” he said.

As a result, Georgia’s tourism industry held up fairly well even during the worst part of the pandemic. Plus, people were actually able to go out and walk on the beach.

“We had some regulations around that, but people could get out there and do some exercise and give their kids something to do,” Mr. Kemp said. “We had people from other states coming and putting in in our boat ramps because they just needed some sanity to get out on the lake and go fishing or do whatever.”

Mr. Kemp said his approach was to strike the right balance and not get paralyzed by the public health experts. “I know they had a job to do,” and the state’s commissioner of public health, Dr. Kathleen Toomey, “did too, but she was one of the best and well-trained epidemiologists in the world who was advising me,” he said.

“We didn’t do mandates on the vaccine or mask, and we pushed hard to get our kids back in the classroom because both Dr. Toomey and I said early on that we got to think about the livelihood effect of people not having economic viability, not having their kids in the classroom, just how hard that is for parents to have to deal with that with no outlet,” he added.

“I took a lot of grief from it just because of my political situation on other things that were going on with the president and just those politics,” he said. Early in the pandemic, people may forget, Mr. Trump himself and several mayors were very critical of Mr. Kemp’s failure to lock down his state.

“It was a tough time to go through,” said Mr. Kemp. And he left the criticism of Mr. Trump at that. “But also, it was just listening to those folks that were worried about losing their business, and they were worried about where their kids were going. ... What was going to happen to their kids? And that’s really who we were fighting for.”

Mr. Kemp has now filed paperwork with the Federal Election Commission to create Hardworking Americans Inc., a federal political action committee that he plans on using to help Republican candidates for federal office in Georgia.

He says standing up for policies and principles is just what he does. He adds he doesn’t do it for personal benefit, though sometimes it works out that way.

“In some ways, us standing up to Major League Baseball after we passed the election bill was one of the really first times that somebody started standing up to the woke cancel culture, if you will,” he said.

“We never backed down from that either, which ended up, looking back, really helped me in the primary and in the general.”

Kemp added that he wanted to help other Republicans stand up in similar fashion going forward.

https://www.nysun.com/article/brian-kemp-beat-trump-stacey-abrams-and-the-corporate-left ?

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Surprise: WSJ Uncovers 'COVID Spending' Scandal

One of the eternal truths of politics is that governments are generally very bad at allocating resources efficiently and effectively, especially under the auspices of "emergency." The bigger the government, the more true this reality generally tends to be. Even – or especially – when government intervention or spending is obviously called for, as was the case during the COVID pandemic, shoveling large sums of money out the door as quickly as possible will inevitably lead to the old cliched triumvirate of waste, fraud, and abuse. This recent emergency binge was no exception, witnessing waste, fraud and abuse on a mind-blowing scale.

The Wall Street Journal has uncovered one example of this phenomenon, revealed in a new investigative report:

When Covid-19 struck, the U.S. government gave hospitals tens of billions of dollars to help them cope with the strains of the pandemic. Many of the hospitals didn’t need it. The aid enriched some well-off systems, while failing to meet the needs of many that were struggling, according to a Wall Street Journal analysis of federal financial-disclosure reports. The mismatch stemmed in part from the way the federal government determined how much a hospital should get. A main factor used to allocate relief was a hospital’s revenue, rather than Covid caseload or financial distress. The idea was that revenue was a good indicator of a hospital’s size.

Among the recipients were large, wealthy hospital owners—including some nonprofits—that reported profits from patient care during the periods they got aid. Some were well off enough to put money into investment funds, while others spent on new facilities and expanded campuses. Hundreds of other hospitals that got federal funding, however, reported losses. Some were forced to lay off nurses and make other cuts, saying they didn’t get enough aid to overcome their strains. Some served areas that had among the highest Covid death rates. The revenue-based award system, especially prevalent in the early days of the pandemic, tended to favor hospitals with higher prices

Some mistakes are unavoidable in an undertaking of this scope and magnitude, along a very accelerated timeline, but the Journal piece painstakingly reviews pieces of how "more than $175 billion in aid to a range of healthcare providers, including hospitals, doctors, dentists, clinics, nursing homes and other facilities," mostly within the window of a year-and-a-half stretch. Meanwhile in Florida – where the state government was remarkably effective in the aftermath of the devastation of Hurricane Ian this fall – Gov. Ron DeSantis has announced additional aid from Tallahassee to homeowners in need, after he said FEMA has declined some requests for assistance:

Gov. Ron DeSantis announced in Southwest Florida, the region of landfall for Hurricane Ian, that Florida will pay $25 million of its own money for emergency relief in light of FEMA denying the state’s request. “Unfortunately, we got word last week that FEMA had denied our request for funding our state-led housing initiatives, citing their quote ‘limited authority.’ But we’re not just gonna sit there and take no for an answer,” he said. FEMA sent a Dec. 2 letter to the DeSantis Administration issuing denial for a request to expand the state’s housing recovery program: "Due to the limited authorities FEMA has to approve and pay for this type of work, as well as our inability to confirm that authorizing this policy expansion would achieve the intended outcomes for disaster survivors, your request is denied."

I suspect we haven't heard the last of this dispute.

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH)

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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Tuesday, December 06, 2022


Long COVID: How clusters of symptoms have emerged and changed over the pandemic

Since the first COVID "long haulers" were reported in 2020, millions of people have experienced long COVID.

While long COVID has no strict definition, it's generally used to describe an illness following a SARS-CoV-2 infection with symptoms that last at least two to three months.

It can manifest as a whole suite of symptoms ranging from body aches and pains to brain fog, and these can substantially vary between people, says Lou Irving, respiratory physician and head of the Royal Melbourne Hospital's post-COVID clinic.

But under that broad "long COVID" umbrella, clusters of symptoms have emerged, and as the pandemic's worn on, those symptoms have shifted.

Senior respiratory physiotherapist Janet Bondarenko has been working in Melbourne's Alfred Hospital post-COVID clinic since its doors opened two years ago.

Early on, most people referred to the post-COVID clinic had been severely sick and many hospitalised. "We saw a lot of breathlessness in people, and they could only manage walking a few metres at a time," Ms Bondarenko says. "Then we started to see memory and concentration issues."

And while she still sees these symptoms in patients now, she also sees more people with heart-related symptoms. "If they're going from sitting to standing, their heart rate will jump and they'll get palpitations, chest pains, things like that," Ms Bondarenko says.

This is an example of what's known as "autonomic dysfunction", where a part of our nervous system that controls things like blood pressure doesn't work properly.

If a person's blood pressure drops, their heart has to work harder and pump faster to compensate and keep blood moving around the body. This, in turn, produces symptoms such as dizziness and extreme fatigue.

"What's interesting is people now often present with breathlessness, but it's not breathlessness caused by the respiratory disorder," Ms Bondarenko says. "It's breathlessness from fatigue and from this autonomic dysfunction."

New data from Australia's longest-running post-COVID clinic has revealed a high proportion of patients are women in their 40s and 50s, painting a picture of who might be more affected by this emerging condition.

Jason Kovacic, a cardiologist at the Victor Chang Cardiac Research Institute, says it's still the case that a very sick person is more likely to develop long COVID, but now people with an extremely mild case can end up in a bad way.

"I have a couple of notable patients who just can't nail down when they had COVID, but they came to the clinic or to the ER with a full hand of long COVID symptoms," Professor Kovacic says.

"They're dizzy, lightheaded, fatigued, and short of breath, and they get to see me because they've got a resting heart rate of 120 and a blood pressure of 90 over 60."

First, Professor Kovacic runs tests to rule out other causes of low blood pressure and fast heart rate, such as myocarditis. "But this group of people tend to have a normal heart that's beating fast with low blood pressure and palpitations and, understandably, a lot of anxiety as well."

Why the shift in symptoms?

Just as different variants (and subvariants) of the SARS-CoV-2 virus have wreaked various levels of havoc on our body, it appears they impart different lingering after-effects too.

"Different strains of the virus are interacting with immune systems differently and triggering different events," Professor Kovacic says.

"The likelihood of getting long COVID was probably double with Delta than what it is with Omicron.

"I think that really speaks to this interaction of what the specific strain of the virus is doing, and how that interacts with the immune system of each person."

Exactly why long COVID develops in some people and not others is still a mystery, but our genetics likely plays a role, as does our history of previous conditions.

Some studies suggest COVID-19 infection can reactivate the Epstein-Barr virus, which causes glandular fever and is linked to chronic fatigue syndrome.

"They're not the same conditions, but there are parallels between chronic fatigue and long COVID, and some of the immune dysfunction that's related to glandular fever is very similar to what happens with long COVID," Professor Kovacic says.

Professor Irving suspects researchers will eventually discover subtypes of sorts within the broader "long COVID" cohort. "I think we'll find there are groups where the virus can activate autoimmune responses, in some people it can activate autonomic responses, and in others it can bring out mental health issues."

While vaccination may lower our risk of developing long COVID, the only surefire way is to not get infected with COVID-19 in the first place.

Management and recovery

The goal for post-COVID clinics is to get people back to their usual activities while managing symptoms.

Treatment depends on each person's symptoms, but recovery typically involves plenty of rest to start, then taking lots of short breaks as activity slowly builds.

Exercise rehab can be helpful too, Ms Bondarenko says, but not for everyone.

"There's two different clusters: some people respond well to exercise but for other people, it could potentially make them worse."

Some people with severe symptoms such as postural orthostatic tachycardia syndrome, or POTS, a condition where most of your blood remains in your lower body when you stand up, can benefit from medications.

But recovering from long COVID takes time, and for most, that's between six and 12 months, Ms Bondarenko says.

"Often the concentration and brain fog is quite highly linked with fatigue, so once the fatigue starts to get better, all those other symptoms tend to resolve as well. "But it does get better with time, and most people get better."

Professor Irving agrees. "Common roadblocks are frustration, doing too much too soon, which can set you back, and financial worries, because not everyone can afford to take time off.

"But from experience, everybody gets better — it just takes time."

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Mask wearing disrupts decision-making ability, Australian study finds

Mask wearing can seriously disrupt a person’s ability to make decisions, particularly when they feel under pressure, a new Queensland study has found.

Dr David Smerdon of the University of Queensland's School of Economics studied 8500 worldwide chess players aged between 5 and 98, comparing how they played a game of chess both with and without masks on.

After analysing almost three million individual chess moves he found wearing a mask substantially reduced the quality of a player’s decisions.

But the disruption to decision making was also only temporary and players were able to recover from their initial brain fog within four to six hours, before returning to their normal playing capability.

“We found that the early part of the game you’re not playing as well as you usually would,” Dr Smerdon said.

“The data showed masks were more likely to decrease performance in situations where there was a demanding mental task with a high working memory load.

“The decrease in performance was due to the annoyance caused by the masks rather than a physiological mechanism, but people adapted to the distraction over time.

“The results suggest that the effect of masks may depend on the type of task, the duration of the task and working memory load.”

Dr Smerdon said it was important to find out what -if any- kind of effect mask wearing had on the general population, with his initial findings also indicating minimal disruptions to children’s decision making.

“From a methodical point of view, it’s been hard to get evidence on this topic and chess gave us those circumstances as it requires calculation, memory, problem-solving and pattern recognition and has been used extensively in psychology, neuroscience and economics to measure changes in cognitive performance,” he said.

“What surprised me was the level of effect for experts, particularly in very important games, the effect is very large.

“When we looked at just juniors, up to the age of 18 we didn’t find any effects of mask (wearing), and that could be because of the comparison of kids to the overall (study) numbers or maybe because they are just more adaptable.”

Dr Smerdon said understanding the impact of mask wearing could help individuals and organisations, particularly if it becomes mandatory again in future.

“A lot of communities have discussed mask policies since they were introduced,” he said.

“This is something to keep in mind for occupations in the STEM fields of science, technology, engineering and mathematics as well as other professions that demand a high level of working memory such as language interpreters, performers, waiters and teachers.

“For example, education policy makers may need to bear in mind the disruptive effects of masks when designing exam conditions to address concerns about student health and fairness.”

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Also see my other blogs. Main ones below:

http://edwatch.blogspot.com (EDUCATION WATCH)

http://antigreen.blogspot.com (GREENIE WATCH)

http://pcwatch.blogspot.com (POLITICAL CORRECTNESS WATCH)

http://australian-politics.blogspot.com (AUSTRALIAN POLITICS)

http://snorphty.blogspot.com (TONGUE-TIED)

https://immigwatch.blogspot.com (IMMIGRATION WATCH)

https://awesternheart.blogspot.com (THE PSYCHOLOGIST)

http://jonjayray.com/blogall.html More blogs

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