Wednesday, April 15, 2020



What Would Hayek Do? Knowledge and Vaccines

Bloomberg opines the key to a lasting solution to the coronavirus pandemic is a vaccine. The most common projection is that it will take a minimum or one year to accomplish. Cooperation and innovation made possible by  open markets may provide the strongest measures yet to solve COVID-19. Do we have reason to optimistically question the current vaccine timeline assumption?

Perhaps the hesitation in making public projections is the number of unknowns and the fear of being wrong, as I heard from one top tier consulting firm hesitant to go public. But fearlessly making these qualified projections and sharing data is vital in the process of knowledge building. Hayek told us the use of knowledge held by dispersed individuals is essential for progress, now so more than ever. Widespread testing (combined with the right isolating behaviour) and finding a vaccine are widely seen as the key to getting the pandemic under control.

The application of knowledge is all too often hindered by regulation: In the instance of testing, Jeffrey Tucker points out the Centers for Disease Control had “previously nationalized all disease testing”. Writing at the American Institute for Economic Research, he says the group had just days earlier  “explained how a private researcher, funded by the Bill & Melinda Gates Foundation, was forcibly prevented from producing and distributing a valid test”.

At the President’s request, “by Friday America’s robust private sector, including Walmart, Walgreens,  CVS, Roche Laboratories, and LabCorp, came up with a solution for mass testing, noted Robert Luddy in the American Spectator mere days later. A multitude of sources have concluded “quick, easy testing was the key to South Korea’s success”.

On the timeline for a vaccine, “European Commission President Ursula von der Leyen surprised the world this week, suggesting that the regulatory process for vaccines could be sped up and that a coronavirus shot could be on the market within six months,” reported ABC News Australia. Her comment is at odds with the World Health Organisation (WHO), “which does not expect a fully-tested and approved vaccine to be ready to reach the market before the middle of 2021”.

CureVac, a German biotech company working on a coronavirus vaccine, was the inspiration for her public comments. It is not the only company making swift progress. A range of discoveries and trials in the testing phases are documented, taking place at lightening speed as new standards are set for responding to a pandemic. In the interim, modest improvements in treatment well-underway are poised to make a significant difference. Peter Diamandis is keeping a tally on some of the major milestones already achieved early this month, with a list that is by no means exhaustive.

As of March 21, there are 48 vaccine candidates in pre-clinical evaluation, and two in clinical evaluation, according to the World Health Organization.

Studies are happening at lightning speed which help inform vaccine development, potentially affecting timelines: “The good news is two independent studies by teams of infectious diseases scientists helping Italy’s fight against coronavirus have reported they found the fast-proliferating pathogen to be reasonably stable,” reports Mark Blunden in the UK: “The findings will add to a better understanding of the virus and how it spreads — and raise hopes that a future vaccine could have a higher rate of effectiveness against the strain.”. On currently available prospective treatments, here at EconLog David Henderson argues safe drugs should not be kept of the market today.

William Yeatman, a research fellow at the Cato Institute’s Robert A. Levy Center for Constitutional Studies, argues COVID-19 has spurred the suspension of regulations that were never needed in the first places so address the situation: The emergency Declaration under Title 42 gives health agencies greater flexibility to suspend regulations that get in the way of responding, with many suspensions recognising the effectiveness of private supply chains in responding.

The Intercept reports Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases recognizes the speed of delivering the manufacturing of a vaccine will come down to the private sector. “The federal government is not going to be able to make hundreds of millions of doses,” he said.

At the state level and federal level, a number of regulations have been eased or temporarily suspended. A number have been on the wish list for elimination during ordinary times, as pointed out during an interview with Yeatman.

Yeatman draws attention to the now well-known “fiasco in Seattle, where private parties had developed fairly effective tests for COVID and used it in violation of the law and FDA” as an example of rigidity that existed, citing New York Times coverage of the story. By going ahead before the regulatory roll-back, private players “arguably saved a lot of lives”.

Loosening of licensing regulations for nurses is another tangible, where previous measures had precluded a number of well-qualified and well-meaning people from getting behind the response.

Constitutional research fellows and economists don’t carry scientific credentials but may have a key role in crisis: to demonstrate the necessary conditions for the maximum application of scientific knowledge in an enabling environment, one that is conducive to the capital and collaboration necessary to fight COVID-19 or any future pandemic – and come out stronger, even if such a prospect seems distant in these tough times.

Hayek once noted “the range and variety of government action that is, at least in principle, reconcilable with a free system is (…) considerable”. Those actions include rolling back barriers to finding a solution in addition to new measures underway.

SOURCE 

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Could a 100-year-old vaccine protect against COVID-19?

Scientists around the world are racing to find ways out of the new coronavirus pandemic. Some are working to develop new drugs and vaccines, while others are looking to see whether therapies we already have may help against COVID-19.

In the latter category, researchers have dusted off one intriguing compound in our collective medicine cabinet — a century-old vaccine to fight tuberculosis, a bacterial disease that affects the lungs. A couple of early analyses, which have yet to be peer-reviewed, have found that countries that require this vaccine, called Bacillus Calmette–Guérin (BCG), seemed to have been hit less severely, in terms of both number and severity, by the coronavirus that causes the disease COVID-19.

Could this vaccine be protecting people from COVID-19? The short answer is: We don't know. But several clinical trials around the world are now examining whether this vaccine could protect against this new foe.

"I was originally quite skeptical" that the studies could tease apart all of the other factors that could be causing some countries to be hit harder with COVID-19 than others,” said Paula Cannon, a distinguished professor of molecular microbiology and immunology at the University of Southern California's Keck School of Medicine, who is not a part of any of these studies. Among those factors are the quality of the healthcare system, measures put in place to fight the disease and testing capacity.  Still, it is a "provocative idea" and the "data is tantalizing," Cannon said.

Dozens of countries, including Japan and China, require children — typically newborns — to receive the BCG vaccine as protection against tuberculosis, an infection that is typically more common in lower-income countries. Other countries, such as Spain, France and Switzerland, used to require the vaccine but stopped because the risk of catching the disease in those countries lessened, according to one of the preprint studies published in medRxiv on March 28. Other countries, such as the U.S., Italy and the Netherlands never had such a universal vaccine policy for the BCG vaccine.

But scientists have long known that "almost by lucky accident," the BCG vaccine doesn't just protect against tuberculosis, it also helps fight other viruses, respiratory infections in particular, Cannon said. The vaccine, "in some sort of unexpected and magical way, is like a broad immune booster," she said.

For example, one study conducted in Guinea-Bissau in West Africa found that children who were vaccinated with BCG had about a 50% reduction in overall mortality, largely because the vaccine reduced respiratory infections and sepsis, or blood poisoning, according to the medRxiv study. Other studies, mostly conducted in animals, have found similar broad-spectrum protections from the BCG vaccine.

Weakened, live bacteria vaccine

The BCG vaccine is made up of weakened forms of live Mycobacterium bovis, closely related to the bacteria that causes tuberculosis. It was first developed in the 1920s in Paris and later shipped all over the world.

Now, countries from Japan to Denmark have their own BCG vaccines, made using different formulations of live bacteria — and each one has varying degrees of immune boosting ability, said Dr. Ofer Levy, the director of the precision vaccines program at Boston Children's hospital and a professor at Harvard Medical School.

Typically, live vaccines provide a "strong and long-lasting immune response" and sometimes even "lifelong protection" against the germ, whereas inactivated forms of vaccines, such as those in flu shots don't provide immunity that's "as strong," according to the U.S. Department of Health and Human Services.

While most vaccines prompt one arm of the immune system — the adaptive immune system — to create antibodies that target very specific pathogens, the BCG vaccine taps into the other arm, the innate immune system. This system doesn't discriminate against pathogens and releases immune cells rather quickly  to fight any foreign substance. The BCG vaccine thus boosts the body's  production of non-specific immune cells.

The medRxiv study and another preliminary study recently published in Research Gate came to similar conclusions: there seemed to be a correlation between countries that require BCG vaccines and a reduced spread and severity of COVID-19 cases. For example, Portugal — which has required BCG vaccines for infants —  has over 16,000 cases of COVID-19  but only 535 deaths whereas neighboring Spain has over 169,000 cases and over 17,000 deaths.

Similarly, Ireland, with 9,655 cases and only 334 deaths, requires the BCG vaccination, whereas the U.K. with 89,554 cases and 11,346 deaths no longer does. Based on these numbers, Ireland has a fatality rate 3.5% whereas the U.K. has a fatality rate of 12.7%. Of course, there are big population number differences across these countries, along with other variables that could affect death and infection rates.

These preliminary studies are "very flawed," because many factors  such as differences in wealth and testing ability, can affect the outcomes Levy told Live Science. But the authors are "doing the best they can in a very difficult situation."  While there's no direct evidence that BCG vaccines will reduce people's risk of developing COVID-19, "I'm enthusiastic about the hypotheses," Levy said.

It's difficult to draw firm conclusions, but there's enough scientific evidence to prompt clinical trials, and his team is looking into starting one in the U.S, he said. Clinical trials analyzing the protective effects of the vaccine against COVID-19 are already underway in other countries, including Australia and the Netherlands.

Vaccination or revaccination?

"I'm kind of puzzled," by the implication that the BCG vaccine might be able to protect for such a long period of time once someone has received it as a baby, Cannon said. Indeed, it's not clear how long the BCG vaccine effects can last.

The second study, which also has not been peer-reviewed, analyzed how countries with re-vaccination policies — or booster shots — fared in the COVID-19 pandemic. That study found that countries without re-vaccination policies had a 5.2% case fatality rate, versus a0.6% case fatality rate in countries that required re-vaccination.

"The big kind of asterisk, if you like, against all of these studies, is that they are really dealing with massively incomplete information," Cannon said. "We're all guessing what the true infection rates and the case fatality rates are because there isn't widespread uniform testing in every country."

Still, "I applaud the authors for at least, you know, doing what they could with the available data and providing some very provocative hypotheses," she said. "The good news is they're very testable."

In another world, we would be doing animal experiments to test this hypothesis. In this world, amid the coronavirus pandemic, we don't have time for that, she said. But the BCG vaccine has a "very safe track record," and likely can be tried in those who aren't old and who don't have weakened immune systems (since this is a live vaccine, it can potentially cause more side effects for older people or those with weakened immune systems), she added.

The human immune system is like an orchestra, "it's massively interconnected and what the BCG vaccine seems to do is maybe it gives like a little bit of extra control to the conductor," Cannon said. "So in the symphony of immune attack against respiratory viruses, the orchestra is able to go full blast, straightaway, all together, in sync, rather than kind of playing catch up."

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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Tuesday, April 14, 2020


Mass.: The only way this ends is through herd immunity

It has a bad rap, but in the long run it’s our best hope

Last week Governor Charlie Baker released projections of how many Massachusetts residents were likely to contract the coronavirus. By this reckoning, Baker said, the state would experience “somewhere between 47,000 and 172,000 cases during the course of the pandemic.” This represents between 0.7 and 2.5 percent of the state’s population.

These are daunting numbers. Unfortunately, they are not nearly daunting enough. Because while there is still a lot we don’t know about COVID-19, including exactly how many people are or have been infected, epidemiologists believe that this virus won’t begin to disappear until a far higher percentage of the population — at least 60 percent — develops immunity. If that doesn’t happen with a vaccine, it has to happen through exposure.

SOURCE 

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No, the United States Does Not Lead the World in Coronavirus Cases or Deaths

Last month, the media jumped on the news that the United States had more confirmed cases of the coronavirus than any other nation. That was bogus on two fronts. First, U.S. intelligence agencies believe that China is lying about its true numbers, and reports from inside the country tell of crematoriums working around the clock and people being paid off to keep quiet.

Second, the United States does not lead the world in coronavirus cases per capita—which is the best way to compare how the pandemic is being contained in each country. For much of the pandemic, Italy has been overwhelmed by the coronavirus, but Italy has fewer cases and deaths than the United States. The United States has nearly six times the population of Italy, and when you measure cases and deaths per capita it’s easy to see why Italy was overwhelmed and the United States is not.

Here are the top six countries by confirmed cases (based on the case numbers from the Center for Systems Science and Engineering at Johns Hopkins University as of 9:00 am ET April 12) in descending order (excluding China because their numbers are bogus):

USA (530,006)
Spain (166,019)
Italy (152,271)
France 130,730
Germany (125,452)
The United Kingdom (79,885)

Now, here are the top six countries by confirmed cases per million people (based on population numbers from the CIA World Fact Book) in descending order:

Spain (3319.33)
Italy (2440.14)
France (1926.80)
USA (1593.34)
Germany (1565.03)
United Kingdom (1214.78)

See? When looking at the number of confirmed cases compared to the population, the United States is not number one.

Just like with confirmed cases, when the United States’ whole number of coronavirus deaths passed 20,000, the media rushed in to say that the United States “now leads the world in deaths.” But does it really? Let’s look at the data.

Here are the total confirmed deaths of the top six hit countries in descending order.

USA (20,608)
Italy (19,468)
Spain (16,972)
France (13,851)
The United Kingdom (9,892)
Iran (4,474)

The United States has passed Italy for confirmed coronavirus deaths, that must mean we’re doing worse than they are, right? Wrong. Here are the top six countries for deaths per million people.

Spain (339.33)
Italy (311.97)
France (204.15)
The United Kingdom (150.42)
USA (61.95)
Iran (52.68)

Obviously, the media wants the public to believe that the situation in the United States is worse than anywhere else because that makes Trump look bad. Last month, when President Trump said the United States had done more coronavirus tests than South Korea, the media pounced on the claim and pointed out that the United States’ population is more than six times that of South Korea, and when you looked at testing per capita, the United States was still behind South Korea.

And through it all, the country that seems to avoid criticism from the media is China. They covered up the virus, even led the world to believe that it couldn’t be transmitted human-to-human for weeks. They’re even covering up the true extent of the spread of the disease in their country. Instead, the media chooses to push the narrative that things in the United States are worse than they really are because they hope it will result in Trump’s defeat in November. So, when the media tells you that the United States leads the world in coronavirus cases and deaths, they are wrong. The United States is a very big country, and when you measure coronavirus cases and deaths per capita, we don't "lead the world" at all.

SOURCE 

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'Some people have gone crazy': Eccentric French doctor trialing experimental coronavirus treatment championed by Trump hits back at experts who say it has fatal side effects and claims to get astonishing results

An eccentric French doctor has become a YouTube sensation and been approached by the French president for advice after he claims he has gotten astonishing results using Trump's favorite coronavirus treatment on sick patients.

Didier Raoult, a 68-year-old French infectious-disease specialist, has been using controversial antimalarial drug hydroxycholoroquine to treat COVID-19 patients.

The doctor has a history of defying conventional medicine practices, including blaming the pharmaceutical industry for the state of research, dismissing climate change predictions as 'absurd' and, more baffling still, touting the growing fears in the early days of the coronavirus pandemic 'crazy'.

But Raoult has now become an unlikely hero amid the pandemic, after he said he has given the experimental drug to more than 2,400 patients, with highly positive results.

His stance has divided opinion in France and overseas after many conservative medics warned of the dangers of using the drug to treat the virus, typically used to treat malaria and some autoimmune diseases, due to a lack of evidence over its effectiveness. 

But panicked members of the public view him as a hero in the pandemic, with his each of his YouTube videos getting at least one million views and people urging their doctors to let them try the medication.   

Raoult is not the most conventional of doctors, often sporting a long white beard and a skull ring on his finger in his online videos and being known for challenging conventional medicine throughout his career.

The doctor has spoken out on Twitter and YouTube urging healthcare professionals and governments to not delay their use of hydroxychloroquine until after clinical trials.

Trials could take several months by which point thousands more lives could be lost to the killer virus. 

'Some people have gone crazy with methodology,' Raoult argues in a video posted this week. 'Our objective as doctors is to make people better.'

Emmanuel Macron met Raoult this week at his research institute in Marseille, where the doctor presented his research on coronavirus to the French President. 

French authorities have now permitted the drug to be used in 'the most severe cases.' 

However, Raoult's approach has come under fire from many in the medical world. Several experts have argued that further clinical trials are needed to determine its effectiveness in treating coronavirus.

Concerns have also been raised that it can have fatal side effects, especially in people with pre-existing heart conditions. 

More than 50 cases have been reported where coronavirus patients have developed serious heart problems after taking hydroxychloroquine, according to a doctor at France's drug-safety monitoring center.

Raoult said that 10 of the 2,400 patients he has treated using the drug have died, and recommends it be administered at an early stage of the virus.

Jean-Paul Stahl, a French doctor of infectious diseases, told the Wall Street Journal that he was turning patients away after they have seen Raoult's campaign and are now asking for the drug. 'We have to say no,' Stahl said. 'It's a matter of patient safety.'   

The controversial drug is a favorite of Donald Trump's. During his daily coronavirus press briefings, the president has repeatedly plugged the use of hydroxychloroquine as a miracle cure for the deadly virus. He has even said he'd consider taking hydroxychloroquine himself.

The president announced Sunday the government has purchased and stockpiled 29 million doses of the hydroxychloroquine to send to hot spot areas of the country battling the virus.

'I want people to live and I'm seeing people dying,' he explained Sunday about why he continually touts the drug, which scientists say has not gone under enough testing in regards to the coronavirus.

Chloroquine – sold under the brand name Arlan – kills malaria parasites in the blood, stopping the tropical disease in its tracks.

But tests of the drug – which has been used for 70 years – on COVID-19 patients in China show it has potential in fighting the life-threatening virus. Chinese officials claimed the drug 'demonstrated efficacy and acceptable safety in treating COVID-19 associated pneumonia'.

South Korea and China both say the drug is an 'effective' antiviral treatment against the disease, according to a report by US virologists.

The Wuhan Institute of Virology – in the city where the crisis began – claimed the drug was 'highly effective' in petri dish tests. Tests by those researchers, as well as others, showed it has the power to stop the virus replicating in cells, and taking hold in the body.

Twenty-three clinical trials on the drug are already underway on patients in China, and one is planned in the US and another in South Korea.

Professor Robin May, an infectious disease specialist at Birmingham University, said the safety profile of the drug is 'well-established'.

He added: 'It is cheap and relatively easy to manufacture, so it would be fairly easy to accelerate into clinical trials and, if successful, eventually into treatment.'

Professor May suggested chloroquine may work by altering the acidity of the area of cells that it attacks, making it harder for the virus to replicate.

Chinese scientists investigating hydroxychloroquine penned a letter to a prestigious journal saying the 'less toxic' derivative may also help'.

'I've seen people that are going to die without it, and you know the expression, when that's happening, they should do it. What really do we have to lose? We also have this medicine's been tested for many years for malaria and for lupus, so it's been out there. It is a very strong powerful medicine, but it doesn't kill people,' the president said.

'But what do I know? I’m not a doctor,' Trump conceded.  'I'm not acting as a doctor. I'm saying, do what you want.'

The president has also argued there isn't time to conduct in-depth studies on hydroxychloroquine's effect on the coronavirus.

'I would love to go to a laboratory and spend a couple of years testing something. We don't have time. We don't have two hours because there are people dying right now,' he said.

But his claims have often contradicted his own advisers, who say studies of its effectiveness are still too small to prove it is safe.

Dr Tony Fauci has previously warned against seeing the malaria medication as a wonder drug, saying Americans should not consider it a 'knock out' drug when it comes to treating the coronavirus. 

'We’ve got to be careful that we don’t make that majestic leap to assume that this is a knockout drug. We still need to do the kinds of studies that definitely prove whether any intervention is truly safe and effective,' he told 'Fox & Friends' last week.

Some doctors in the US have already started treating patients with the drug but there have been reports of at least one death connected to the medication.

Lack of availability is also sparking a worrying trend for people self-medicating with hydroxychloroquine.

Demand for a cure is ramping up as the US death toll topped 20,000.

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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Monday, April 13, 2020

Cure for coronavirus? The antimalarial drug hydroxychloroquine (HCQ)

Worried Medicaid patients in an urban emergency room are reportedly asking doctors for “dat Klorokine pill.” Meanwhile, highly educated persons are quoting media reports that HCQ is very dangerous because it can trigger fatal heart rhythms.

Governors and state medical and pharmacy boards are threatening physicians who prescribe and pharmacists who dispense HCQ for COVID-19. One rationale is that lupus and rheumatoid arthritis patients might not be able to get their prescriptions filled from the millions of doses drug manufacturers are now cranking out. Apparently, HCQ is not too dangerous for them.

Evidence is pouring in from around the world, including Los Angeles, where very ill patients were symptom-free within 12 hours after receiving HCQ combined with zinc.

In Brazil, HCQ plus azithromycin is being sent to patients’ homes based on a telemedicine consultation, and patients are reportedly cured at home. Virologist Paolo Zanotto of the University of São Paulo states that the drug should be given before day 5 to prevent lung damage. He believes opposition to the drug is political: President Trump and Brazilian President Bolsonaro have recommended it.

“If the people were not saying that this is ‘Bolsonaro’s remedy’ or ‘Trump's remedy,’ it would be different. If it were ‘Doria’s drug’ or ‘Lula’s drug,’ I guarantee it would be a success. There is a lot of ideology involved in the problem. For some, if the death of millions is needed to take Trump and Bolsonaro out, so be it.”

Can HCQ cause heart rhythm disturbances? Yes, but rarely. These have occurred in ICU patients who had heart damage from the coronavirus. Can it kill you? Very rarely—everybody has heard about the man who drank aquarium cleaner containing ten times the recommended dose of chloroquine.

Are there controlled, peer-reviewed studies? No. These take years; this novel coronavirus has been known for about 4 months.

Are Americans willing to learn from patients and Brazilians? Will American doctors be allowed to try promising drugs before millions are denied “unproved” remedies?

SOURCE 

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Haywire Immune Reaction Linked to Most Severe Cases

An immune system gone haywire may be doing more damage than the coronavirus itself in patients with the severest forms of Covid-19, doctors and scientists say, a growing theory that could point the way to potential treatments.

Much remains unknown about the path the virus takes in the sickest patients, but an increasing number of experts believe a hyperactive immune response, rather than the virus, is what ultimately kills many Covid-19 patients.

The out-of-control immune response eventually causes the patients’ lungs to stop delivering oxygen to the rest of organs, leading to respiratory failure and in some cases death, the experts said. The malfunctioning immune system might be driving the rapid decline in lung function experienced by some patients, including younger and relatively healthy ones, after the initial onset of symptoms, doctors said.

As scientists race to better understand the phenomena, pharmaceutical companies including Roche Holding AG are partnering with hospitals to explore whether drugs proven to tamp down an out-of-control immune response could help the sickest Covid-19 patients.

Some doctors are already administering the drugs to patients who are unable to breathe without the support of ventilators, or to prevent deterioration of patients who appear ready to slip into respiratory failure.

“You remove one piece of the storm, and it can quiet the whole thing,” said Kevin Tracey, president of the Feinstein Institutes for Medical Research at Northwell Health, which is testing Kevzara, an anti-inflammatory drug from Regeneron Pharmaceuticals Inc.

Doctors have used the term “cytokine storm” to describe an overactive immune response triggered by external pathogens such as bacterial and viral infections. Proteins called cytokines are part of the immune system’s arsenal for fighting disease.

When too many are released into the bloodstream too quickly, however, it can have disastrous results, including organ failure and death.

As with other diseases, it is a mystery why cytokine storms are experienced by some but not all Covid-19 patients, doctors said. Genetics may be a factor.

In the most severe coronavirus patients, the disease appears to have two stages, doctors and researchers said. First the immune system fails to respond quickly or effectively enough to the virus. Then the immune response becomes too aggressive and floods the body with cytokines.

The surge of cytokines damages blood vessels and allows fluids to seep into the lungs, filling them up like water balloons, doctors say.

“The virus initiated it,” said Ya-Chi Ho, an assistant professor at the Yale School of Medicine who studies infectious diseases. “The second problem is our immune system handled it wrongly, and induces this cytokine storm and clogs our lungs. That’s why patients die.”

Drugs called corticosteroids can be used to treat patients with cytokine storms, but studies are mixed on their effectiveness, with some studies indicating that Covid-19 patients might be at a higher risk of death when treated with steroids. Some doctors are reluctant to use steroids because they broadly damp the immune response, which is risky in patients fighting infections.

Drugs targeting specific cytokines rather than the entire immune system may be more effective, doctors said.

Among the most promising targeted treatments, doctors said, is Roche’s rheumatoid-arthritis drug tocilizumab, which is marketed under the brand name Actemra. The drug was approved in 2017 to treat cytokine storms caused by cancer treatments known as CART cell therapies.

On Tuesday, a federal agency that supports health research said it is committing $25 million to accelerate a late-stage study of Actemra in Covid-19 patients.

Last month, doctors from Seattle’s Swedish Health Services used Actemra to treat a 45-year-old emergency-room physician who was infected while caring for patients from a nursing home in Kirkland, Wash.

The man was transferred to Swedish and put on life support after his lungs and kidneys began to fail, said Samuel J. Youssef, a cardiothoracic surgeon at Swedish. Lab tests showed the man’s inflammation levels were 200 times greater than the normal range, indicating he might be suffering from a cytokine storm.

The doctors at Swedish decided to administer Actemra after discussing a small Chinese study that had shown that 21 Covid-19 patients with high levels of inflammation had been successfully treated with the drug. Over the next two days, the patient’s inflammation levels began to decline and his blood-oxygen levels increased, Dr. Youssef said. After a week, he was well enough to be taken off life support on March 23, and was released from the hospital on Sunday.

“All we did was quiet the storm and support his body— his kidneys, his lungs, his heart—to give him the time to fight the virus,” said Dr. Youssef, who attributes the recovery both to Actemra as well as other interventions like being put on life support.

SOURCE 

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Are we all authoritarians now?

‘China bans 23million from buying travel tickets as part of “social credit” system’, said one outraged headline in the Guardian, just one year ago. The Chinese social-credit scheme set out to penalise citizens for their errant behaviour while rewarding others for good behaviour. The State Council, China’s chief administrative authority, said the scheme’s purpose is to ‘allow the trustworthy to roam everywhere under heaven while making it hard for the discredited to take a single step’.

Such an insidious assault on civil liberties by the Chinese state, under the guise of protecting social stability, was roundly and rightly condemned in the UK as authoritarian, illiberal and staunchly un-British. Britain firmly believes in the autonomy of the individual and the right to free movement, it was said. The Chinese Communist Party’s dictatorial actions were held up as exemplary evidence of the differences between our two countries and our two systems.

One year later, the Sun newspaper reports that British Transport Police have been ‘deployed… to enforce a ban on unnecessary travel’. The Guardian dutifully announces that ‘Dominic Raab advises UK public to avoid all non-essential travel’. The BBC unquestioningly reports the London mayor proclaiming that key workers and ‘nobody else’ should be using public transport. The freedom of movement ideal was ditched rather quickly. Suddenly, the British government has restricted travel for almost 60million citizens – the same number of people quarantined in China’s Hubei province – but this was hardly questioned in the media.

The West has also long criticised the covert monitoring of citizens carried out by China’s ruling Communist Party. The government stalks the public’s social-media activities to find details of illicit online behaviour. It films people secretly using CCTV and drones. Ordinary people are encouraged to send in their own footage to the authorities to ensure that the state doesn’t miss anyone in its official trawl. Last year, the Wall Street Journal compared China’s attempts to enrol the public to snitch on miscreants to the East German Stasi. Fast forward six months and the same paper reports casually on Western internet users ‘naming and shaming people they believe have flouted lockdown orders, travelled or socialised recklessly’, without making any moral judgement on the shamers.

How have we lost our moral compass in such a short space of time? The medical basis for state-enforced isolation is still debatable. But even if it is a fundamental necessity to protect lives, should we be welcoming confinement so eagerly? Should we really be asking for ever-more state powers to enforce lockdowns? Shouldn’t we be defending liberty, free movement and assembly rather than accepting restraint at the behest of the political and medical establishment?

I am not suggesting that we all rush out and hug each other, but it seems that Western values can be usurped and abandoned much more easily than we ever imagined. That ought to be a cause for concern, and maybe something worthy of national debate. Instead, those advocating for the liberal rights that have upheld the cause of Western societies for centuries are frequently shouted down and branded ‘irresponsible’ or ‘dangerous’. In the words of the Chinese state, penalties will be enforced in order to ensure a harmonious society. Responsible citizens and trustworthy actions are rewarded; dissenters are blacklisted.

One Chinese dissident warned that China’s social-credit system would give ‘officials unparalleled scrutiny over every minute of everyone’s life’. So what are we to make of Google’s announcement last week – made without permission from any of us – that it will release all of our location data to the authorities? It seems that the footnote ‘in order to prevent the spread of coronavirus’ is all that is needed to justify such a monstrous breach of privacy. Facebook is also in talks with the US government about the possibility of sharing our location data. After months of alarmist criticism of Huawei’s potential to reveal users’ data to the Chinese state, few in the media or Twittersphere are raising critical concerns about the same thing happening in the West. Some are raising their glasses. After all, it might save lives, so it’s all right, apparently.

The media seem to have forgotten the maxim of ‘holding truth to power’ and are perhaps intent on simply holding power. During China’s Cultural Revolution, intellectuals were forced to participate in ‘struggle sessions’ – a vicious form of public humiliation. There were echoes of this at the weekend when Scotland’s Chief Medical Officer, Catherine Calderwood, was forced to make a grovelling televised appearance to beg for the nation’s forgiveness. She had ‘made a mistake and let people down’. ‘I cannot justify it’, she said. ‘I did not follow the advice I am giving to others, and I am truly sorry for that… What I did was wrong.’ The media were delighted with the scalp. Her crime? She had driven to her second home in a car.

Actually, there is one good lesson to learn from China, and that is the proud – and often unsung – tradition of rebellion. China has had a couple of revolutions, after all. In recent weeks, thousands of migrant workers and working-class protesters from Hubei province have revolted, overturning police cars and fighting with state forces who refused to allow them to cross over into the neighbouring Jianxi province. These desperate people have been locked down for months. They have no work and no money, even though they are healthy. But the neighbouring provincial authorities were worried about the risk of the second wave of the virus.

In these topsy-turvy times, the best lesson to take from China is how, even in the most dire circumstances, ordinary people can still keep the spirit of free movement, critical engagement and non-complicity alive.

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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Sunday, April 12, 2020

No lockdown in Sweden

by Jeff Jacoby

DID SWEDEN BLUNDER? Or did everyone else?

In response to the COVID-19 pandemic, most of the world's governments have gone to unheard-of lengths to keep people apart and try to slow the spread of the virus. Schools and businesses have been shuttered, public gatherings banned, construction projects halted, restaurants darkened, air travel grounded, borders locked. Tens of millions of "nonessential" workers have been furloughed or laid off. In some jurisdictions, people are forbidden to leave their homes except for food or essentials. Leaders worldwide have made the wrenching decision to incur a devastating economic recession in order to prevent a devastating death toll.

But not in Sweden.

In Scandinavia's most populous nation, life has continued more or less normally. Public gatherings of more than 50 people have been banned. Grade schools and day care are still open. So are parks, restaurants, stores. Streets are still full of people. Swedish health officials have advised residents older than 70 to stay home and emphasized the importance of hand washing. But unlike elsewhere, their public messaging has not reflected frantic desperation.

Why has Sweden adopted an approach so different from other nations'? Not because the country has been untouched by COVID-19. Far from it: As of Tuesday, it had recorded 7,693 confirmed cases and 591 deaths. Sweden's coronavirus death rate (fatalities per million residents) is 59 — markedly higher than that in the other Scandinavian countries, all of which are enforcing stiff social-distancing restrictions. Then again, Sweden's infection and death rates are far lower than in Switzerland, a country of comparable population. Switzerland is in lockdown. Yet three times as many infections have been confirmed, and the death rate is 94.

Such widely divergent results help explain why Sweden's health authorities, led by state epidemiologist Anders Tegnell, have charted a different course. Their goal has been to keep sickness rates low enough that hospitals aren't overrun, without taking a sledgehammer to the economy and throwing vast numbers of people out of work — because unemployment, too, correlates with increased mortality.

Like epidemiologists everywhere, Tegnell is operating in uncharted territory and making projections on the basis of mathematical models. But scientists are using different models and coming to conflicting conclusions. In Britain, researchers at Imperial College London calculated last month that without draconian social distancing measures, as many as 250,000 UK residents might die. A few days later, scientists at Oxford, working from a different model, reported that more than two-thirds of the British population might already have been infected without knowing it — implying that widespread resistance to the virus was already accumulating through "herd immunity."

No one knows yet which conclusion will turn out to be right. Most governments have opted for extreme restrictions, and the severe economic pain they entail, in hopes of keeping deaths from spiking uncontrollably. Sweden's health officials, who are granted considerable autonomy under Swedish law, have so far resisted that approach. Tegnell isn't dogmatic about his position — in a BBC interview, he acknowledged "self-doubt" and said he is "more than prepared" to switch gears if developments warrant.

Swedish culture is highly trusting, but Swedes aren't being asked to take their government's policy on faith. "Hospital data is published all the time, so Sweden's 'experiment' is being conducted in the open," writes Fraser Nelson in the Telegraph. "Every time a patient is admitted, the data is updated on a COVID-19 live website. . . . If Tegnell's analysis proves wrong, the public will be able to see it unravel on his dashboard."

Critics of the strategy haven't been shy. One Swedish epidemiologist called it "a huge experiment" that could "crazily" wrong. An immunologist at the prestigious Karolinska Institute warned that the policy "is leading us to disaster." Some lawmakers are proposing tighter coronavirus restrictions. At the same time, other Swedes have strongly defended the non-lockdown policy — including Johan Giesecke, another Karolinska scientist and author of a textbook on infectious disease epidemiology.

So did Sweden blunder? Or did everyone else?

All we can say at this point is that it's too soon to be sure. But by marching to the beat of its own drummer, Sweden is making it possible for scientists to evaluate competing strategies in real time. However the experiment turns out, we'll all have a clearer idea about the best way to fight pandemics in the future. Sweden's anomalous approach may succeed or it may fail. Either way, mankind stands to gain.

SOURCE 

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Projected death toll dramatically lowered after anti-malaria drug approved

Americans for Limited Government President Rick Manning today issued the following statement reacting to the IHME’s death toll projections being lowered to 60,415 from 81,766:

“Projections on the number of cases of COVID-19 are far less important than the actual deaths from the China-originated virus.  Now, the most influential projection of future deaths from the disease has lowered that guess again. Just one week ago on April 1, the death projection was 93,651, it was lowered on April 4 to 81,766 and just one week into April the projection is now at 60,415.

“While the public health care bureaucrats will attribute the precipitous drop in the all-important death projections to social distancing, the model assumed that social distancing would be implemented in its projections.

“What has significantly changed in the past week was President Trump’s successfully convincing the Food and Drug Administration to allow the anti-malaria drug, hydroxychloroquine  and other antivirals to be prescribed to treat the disease on March 31.  While correlation does not necessarily mean causation, it is significant that doctors across the nation have been given the go-ahead to use this treatment and many are reporting success that should not be discounted.  Those governors who are restricting the use of this medicine need to reevaluate that political decision in order to help save as many of the lives of their constituents as possible.

“President Trump has put the health of Americans first and has risked his economic legacy to protect American lives. Now, as the death projections continue to collapse, Americans for Limited Government urge the country to come behind President Trump as he looks toward restarting the economy. The great news that we are winning the war against the COVID-19 virus will hopefully lead to our economy re-opening around the country not suffering as a hot spot by May 1.”

SOURCE 

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'Social Justice' in a Pandemic

America is in the midst of the coronavirus pandemic and the resulting economic meltdown caused by shutting everything down. It’s affecting every American in some way, and we’ll need to unite to get through it. The worst may be yet to come.

“This is going to be the hardest and the saddest week of most Americans’ lives, quite frankly,” said U.S. Surgeon General Vice Admiral Jerome Adams over the weekend. “This is going to be our Pearl Harbor moment, our 9/11 moment. Only it’s not going to be localized. It’s going to be happening all over the country.”

Unfortunately, unity is not exactly this nation’s strong suit in recent years. Some are trying to fit the round peg of COVID-19 into the square hole of social justice.

“COVID deaths are disproportionately spiking in Black + Brown communities,” complained Rep. Alexandria Ocasio-Cortez. “Why? Because the chronic toll of redlining, environmental racism, wealth gap, etc. ARE underlying health conditions. Inequality is a comorbidity. COVID relief should be drafted with a lens of reparations.”

This is, of course, in line with the Democrats’ view that the current crisis is a “tremendous opportunity to restructure things to fit our vision.” But it’s also an extension of their view that America is such a racist backwater that even equal-opportunity viruses actually target minorities.

It does seem to be true that, at least in some areas, blacks are contracting and dying of COVID-19 at a higher rate. According to ProPublica, “As of Friday morning, African Americans made up almost half of Milwaukee County’s 945 cases and 81% of its 27 deaths in a county whose population is 26% black. Milwaukee is one of the few places in the United States that is tracking the racial breakdown of people who have been infected by the novel coronavirus, offering a glimpse at the disproportionate destruction it is inflicting on black communities nationwide.”

But the numbers don’t tell the whole tale. In fact, ProPublica’s story inadvertently draws attention to something that might be a bigger factor than race. “Louisiana has not published case breakdowns by race, but 40% of the state’s deaths have happened in Orleans Parish, where the majority of residents are black.”

When Hurricane Katrina struck in 2005, residents of New Orleans declined to observe evacuation orders, evidently believing that, no matter what transpired, government would come to their aid — as it does on a daily basis. The resulting death toll there was terrible.

Could it be that the inner-city communities around the country — where populations disproportionately depend on government checks, government food stamps, and government housing — are simply not complying with warnings or protocols regarding the current pandemic? In other words, rather than a failure of social justice, is it a failure to abide by social distancing?

It’s beyond troubling that when so many Americans of every color are legitimately suffering, Democrats are so focused on scoring cheap political points by dividing us.

SOURCE 

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Japan too wants to bring back some manufacturing from China

Coronavirus is causing Japan to reconsider depending on China for its supply and manufacturing base, reports the Japan Times.

Japan has earmarked ¥243.5 billion of its record economic support package to help manufacturers shift production out of China as the coronavirus pandemic disrupts supply chains between the major trading partners.
The extra budget, compiled to offset the devastating effects of the pandemic, includes ¥220 billion for companies shifting production back to Japan and ¥23.5 billion for those seeking to move production to other countries, according to details posted online.

It's not a huge amount of money yet but the trend it bucks is important. Japan's relationship with China has gotten complicated over the past few years. They're longtime rivals but China has made itself Japan's top trade partner while, at the same time, threatening Japan's sovereignty over the Senkaku Islands just this week. Prime Minister Shinzo Abe has sought warmer relations with China despite this. But the pandemic is forcing his hand. It's unwise for any nation to depend on communist China too much for anything, given its habit of lying about important things.

Abe could have reacted to the pandemic a bit quicker.

[M]any in Japan are inclined to blame China for mishandling the early stages of the outbreak and Abe for not blocking visitors from all of China sooner. Until last month, only visitors from Hubei, the epicenter of the outbreak, and one other province had been banned.
Advantage...Trump. Who, by the way, wanted U.S. firms to start leaving China well before the COVID outbreak. Countries that can afford to leave China, will.

Captain Obvious prediction: Taiwan will end up benefiting from some of the coming avalanche of divestment from the mainland. Taiwan is free and transparent, its legal system is predictable, and it has handled the COVID pandemic very well. Because of this, its economy may rebound ahead of others. It also enjoys a defense pact with the United States, which has a decades-long defense pact with Japan.

SOURCE 

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IN BRIEF

Drill, baby, drill: Trump signs executive order encouraging mining for minerals on the moon (Washington Examiner)

Coronavirus was spreading in New York City weeks before first case, compounding the mayor's lackluster response (New York Post)

Kansas legislature cites constitutional rights in rescinding governor's limit on religious gatherings (Washington Examiner)

"We want to have some common approach to this across the state": Arkansas blocks mayors from implementing stay-at-home orders (The Daily Wire)

Nothing to see here... Official Chinese newspaper reports chance of 10,000-20,000 new cases in Wuhan. It's quickly deleted. (The Daily Wire)

Taiwan shows up China, sending hard-hit countries lifesaving coronavirus supplies (Fox News)

Tone-deaf celebrities organize major benefit for China-complicit WHO (The Federalist)

Policy: How Woodrow Wilson let flu deaths go viral in the Great War (RealClearInvestigations)

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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Saturday, April 11, 2020


Meet the former NYT reporter who is challenging the coronavirus narrative

As daily life across America is upended by the coronavirus crisis -- with mass business closures plunging the economy into freefall -- one former New York Times reporter is sounding the alarm about what he believes are flawed models dictating the aggressive strategy.

Alex Berenson has been analyzing the data on the crisis on a daily basis for weeks and has come to the conclusion that the strategy of shutting down entire sectors of the economy is based on modeling that doesn’t line up with the realities of the virus.

"The response we have taken has caused enormous societal devastation, I don't think that's too strong a word," he told Fox News in an interview Thursday.

Berenson is a former reporter who worked for the Times from 1999 to 2010 primarily covering the pharmaceutical industry. He recently came to prominence again with a book, “Tell Your Children The Truth About Marijuana, Mental Illness, and Violence,” which challenged prevailing narratives on marijuana.

In the face of a broadening consensus on both the left and the libertarian right that sees marijuana as mostly healthy and even a positive in some circumstances, Berenson argued that the evidence instead shows a link between the drug and serious mental illness and an epidemic of violence.

Now he’s turned to challenging the narratives on the response to the coronavirus. What Berenson is promoting isn’t coronavirus denialism, or conspiracy theories about plots to curb liberties. Instead what Berenson is claiming is simple: the models guiding the response were wrong and that it is becoming clearer by the day.

"In February I was worried about the virus. By mid-March I was more scared about the economy. But now I’m starting to get genuinely nervous," he tweeted this week. "This isn’t complicated. The models don’t work. The hospitals are empty. WHY ARE WE STILL TALKING ABOUT INDEFINITE LOCKDOWNS?"

Hospitals, of course, are not empty in places like hard-hit New York City, and tales are widespread of overburdened doctors and emergency rooms. Berenson acknowledged as much in the interview Thursday.

Concerns that this virus is significantly more contagious and deadly than any ordinary flu strain are what's driving the current government approach, in America and around the world. Perhaps due in part to more testing, America reports the highest number of cases in the world right now, with more than 430,000 cases and nearly 15,000 deaths. Symptoms vary widely, with some patients reporting only minor discomfort yet others dealing with crushing physical pain and struggling to breathe, forced to go on ventilators.

But Berenson is taking a broader look. He initially challenged the model put forward by the Imperial College in London, when one of the authors of the models appeared to significantly walk back projections that the U.K. would see 500,000 people killed by the disease to closer to 20,000 -- although the author later said that the 500,000 prediction was without social distancing measures, and 20,000 was with them in place. That model is being used to advise the U.K. government on its strategy for the virus.

“That was March 22 or 23, and ever since then I’ve been paying incredibly close attention to the modeling and trying to figure out whether it lines up with what we’re seeing in reality -- and the answer is it hasn’t lined up at all," he said.

Recently he’s been focusing on discrepancies within the University of Washington’s Institute for Health Metrics and Evaluation (IHME) model. That model has come under renewed scrutiny as it has revised its metrics multiple times. It once predicted more than 90,000 deaths by August but recently issued a new estimate that has the figure closer to 60,000. Government officials say it's a model that's moving with what the country is doing.

"We believe that our health care delivery system in the United States is quite extraordinary," Dr. Deborah Birx said at a White House press briefing on Wednesday. "I know many of you are watching the Act Now model and the IHME model— and they have consistently decreased the number, the mortality from over almost 90,000 or 86,000, down to 81,000 and now down to 61,000. That is modeled on what America is doing. That’s what’s happening."

Dr. Anthony Fauci said that the indicators are that social distancing efforts are working: "Because remember, what you do with data will always outstrip a model. You redo your models, depending upon your data, and our data is telling us that mitigation is working."

But Berenson argues that those models have social distancing and other measures baked into them. As for further proof, he says that outside of places like New York there has not been a national health crisis that was predicted -- nor are there signs that the level of lockdown in various states has made a difference.

“Aside from New York, nationally there’s been no health system crisis. In fact, to be truly correct there has been a health system crisis, but the crisis is that the hospitals are empty,” he said. “This is true in Florida where the lockdown was late, this is true in southern California where the lockdown was early, it's true in Oklahoma where there is no statewide lockdown. There doesn't seem to be any correlation between the lockdown and whether or not the epidemic has spread wide and fast.”

He has also argued, in lengthy Twitter threads, that the drop in cases seen in various states has come before lockdowns would have had an impact -- since it takes a few weeks for social distancing measures to take effect due to the window between infection and symptoms.

Berenson blames the models for a response that has effectively shut down large sectors of the economy and is causing significant financial harm to Americans. On Thursday it was announced that the number of Americans seeking unemployment benefits swelled to 6.6 million last week, surging for the third consecutive week. Congress has sought to alleviate the pain by boosting those jobless benefits.

His is a view that has seen some sympathy from President Trump, who has spoken about the "cure being worse than the problem" and has indicated that he is keen to end the strict measures as soon as is possible -- saying Wednesday he wants to re-open the economy with a "big bang."

Berenson says the correct response in the initial days of the crisis would not have been to do nothing, but instead to adopt a more measured and targeted approach.

“There was incredible pressure to do something ... so these lockdowns all cascaded, every governor tried to outdo the next. And no one stopped and said ‘OK what about Japan, they don't seem to have a terrible epidemic, they wear masks, maybe we should wear masks,” he said.

He said other measures such as protecting individuals particularly at risk, and even things such as banning large gatherings such as concerts and sporting events could have been appropriate. But now he fears it may be too late for officials to say they overreacted.

“Now we’re in a bad spot because there’s clearly a dangerous political dynamic right now -- the economy is in freefall, a lot of people are hurting. If we acknowledge what is clearly happening ... the people who made these decisions, I think there’s going to be a lot of anger at them, so they don't want to acknowledge it, so they say 'oh it's the lockdown that saved us,'” he says.

Berenson is not a known partisan. His Twitter feed and other works contain few references to specific politicians, and there’s no indication that he’s in this to bash or defend Trump or either political party. But he noted that, like with his conclusions on marijuana, there has been a distinct lack of interest from the left.

“I went to Yale and I worked for the New York Times, the people on the left hold themselves out as being science-driven, as being smarter, they think they're smarter but they won’t look at facts that won’t meet their narratives,” he said.

He voiced frustration that these arguments have been ignored by a lot of mainstream outlets.

“That is frustrating for me ... but everyone needs to hear this counterargument, whether or not it's right, you need to hear it because the damage we are doing to ourselves right now is so enormous.”

SOURCE 

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Authoritarianism on full display amid the lockdowns

We are going to have to begin today’s Morning Briefing with a preemptive strike/disclaimer sort of thing. I have been writing a lot in the last month about being cautious and responsible while fighting the spread of the virus. I’ve been sticking to the rules and being more isolated than I usually am. Still, I’ve occasionally expressed my wish that we had a clearer endgame and I’ve also mentioned some worries about various petty tyrants using this crisis to turn the Constitution into the toilet paper so many people need right now.

My approach is prudent, my concerns valid.

Every time I attempt to explain that, however, somebody pipes up about me not understanding the gravity of the situation.

I write this from the bottom of my heart as an early response to the first person who wants to pipe up this morning: I’ve been out of my house a total of five times since March 7th, so shut it. I’m taking everything plenty seriously.

Glad we had that talk.

Now let us move on to my disdain for the overreaction of the petty tyrants, like the ones who arrested a man for playing in a park with his six-year-old daughter and wife while trying to comply with social distancing rules.

Sure, the bosses of the petty tyrants let the guy go, but he was still hauled away in handcuffs in front of his family by the local Idiot KGB.

In the more dystopian 21st-century department, a New Jersey city is sending out drones to get all up in the business of the local social distance scofflaws.

Do we all feel safer with our airborne overlords watching over us?

Reiterating: I'M GLAD WE'RE FIGHTING THIS.

A little less totalitarian glee wouldn't be a bad thing, however. That's all I'm saying.

But hey, on the bright side, some of the more heavy-handed municipalities are finding a way to profit off of all of the anxiety and fear:

Manhattan Beach is cracking down on those violating city's physical distancing guidelines. Since zero tolerance policy went into effect last week, officers have issued 129 citations. They say violators can face $1,000 fine

Don't worry kids, the police are assuring us that none of this is reminiscent of a police state.

One of the worst of the petty tyrants has been Eric Garcetti, the mayor of my longtime city of residence, Los Angeles. It's quite obvious that he's relishing his authoritarian turn in the spotlight. He gave everything a Soviet flare last week when he encouraged the citizens of the City of Angels to snitch on neighbors who aren't obeying lockdown rules.

Not creepy at all.

Here in Arizona, we've been told to both stay at home but get outside and breathe some fresh air, as long as we maintain proper social distancing. It seems to be working so far.

Granted, we are quite spread out here in the Southwest -- even in the cities -- so distancing is easier.

My point, however, is that we’re keeping our distance without the threat of arrest from the state. Sure, people from state-to-state are different, but I maintain that human nature tends to react badly to threats, especially when that human nature is also American nature.

We have already been told this week to expect death tolls here in the U.S. that are far lower than originally predicted because we’ve been heeding the social distancing suggestions. Most places haven’t gone full Eric Garcetti while exhorting citizens to remain at home and/or away from each other. We’re still making it work though.

There is a very real possibility that we could have pulled this off without the Eric Garcetti and Gavin Newsom types fetishizing their political authority.

Just sayin'.

SOURCE 

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IN BRIEF

CDC loosens guidelines for some exposed to virus to return to work (NBC News)

CDC releases early demographic snapshot of worst cases, which skew toward those with underlying conditions, men, and African Americans (The New York Times)

Over 300,000 people have recovered from coronavirus around the world (Newsweek)

Ninety percent of federal PPE stockpile depleted amid pandemic (National Review)

A cumulative 16 million and counting: Weekly unemployment claims swell another 6.6 million (Fox Business)

Americans could start receiving relief checks starting today (USA Today)

Regulatory state: Thirty regulations that stymied Trump's virus response (Washington Examiner)

**********************************

For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

**************************


Friday, April 10, 2020

Coronavirus questions that the media slide over

ANN COULTER

It’s probably a coincidence, but I notice that as businesses go under, jobs are lost, careers are ended and trillions of dollars are drained from the economy, the people most avidly pushing the coronavirus panic are doing quite well.

No politician or government official has taken a salary cut. To the contrary, dusty bureaucrats now find the entire country transfixed by their every utterance. Cable news hosts still make millions of dollars -- and now they get to work from home!

Annoyingly, though, journalists can’t seem to relay the basic elements of a news story: who, what, where and why.

First, who’s dying? It appears to be mostly the old, people with specific medical conditions and vapers.

To be sure, that’s not as important as daily updates on Chris Cuomo’s personal battle with the coronavirus, but it might be kind of important to the 17 million Americans who’ve been thrown out of work, many of whom are not elderly, immunocompromised or vapers.

Second, the “what.” What exactly constitutes a “coronavirus death”?

It turns out a person with Stage 4 lung cancer and a bullet through the heart will be counted as a “coronavirus death” if he also tested positive for the disease, OR merely exhibited symptoms associated with it (symptoms that are coextensive with the flu and pneumonia).

We’re told that, if anything, coronavirus deaths are being undercounted because the numbers don’t include those who die of it at home.

If so, then the death count also excludes those who die at home of other things, like heart attacks and poisonings. Many of these people might have survived -- except they were too scared to go to a hospital or couldn't find an EMT to take them there, per current edicts.

The “where” is: Where did the virus originate, and where did it first land in this country?

Despite the media’s best efforts -- DON’T CALL IT THE “CHINESE VIRUS”! -- people know that the virus began at a wet market in China.

But where did it start in this country? Washington state was the site of our very first case. Washington state is also 9.3% Asian. Even now, it has eight times more coronavirus cases per capita than neighboring Oregon (4.8% Asian).

Could it be that Chinese-Americans have more contact with the epicenter of this plague than other Americans? As the left always lectures us, BELIEVE THE SCIENCE!

The virus next leapt to New York (9% Asian) and New Jersey (10% Asian). The worst-hit borough of Manhattan is Queens. Guess which borough has the most Asians? Elmhurst Hospital in Queens is the worst-hit hospital in the nation. Elmhurst neighborhood: 50% Asian.

Notice a pattern? While it’s true that “viruses don’t have nationalities!” -- and thank you very much for pointing that out, media! -- the carriers of viruses do have nationalities.

Arguably, Trump had a reason to shut down travel from China other than “hysteria, xenophobia and fear-mongering", as Joe Biden claimed in a tweet on Feb. 1.

Of course, once it’s here, it’s here and can spread all over. Still, compare New York and New Jersey to, say, Montana and West Virginia.

Chinese virus deaths, so far, by population:

-- New York (9% Asian): 29 per 100,000

-- New Jersey (10% Asian): 13 per 100,000

-- Montana (0.9% Asian): 0.6 per 100,000

-- West Virginia (0.8% Asian): 0.2 per 100,000

Then there’s California, which alone among the four states with the highest Asian populations has relatively few coronavirus cases, probably due to its warm climate and little public transportation, among other things. In those respects, California is a lot like Texas -- which has about a third as many Asians and also about half as many coronavirus deaths (1.1 per 100,000 in California, compared to 0.71 per 100,000 in Texas).

MEDIA: Oh, why does it matter?

OK, OK, you’re right. But isn’t the prevalence of the coronavirus in states with high Asian populations at least as interesting as this recent article in The New York Times magazine?

Story summary:

Man with severe asthma gets coronavirus, has low-grade fever for approximately 10 days with muscle pain, nausea and fatigue, develops walking pneumonia per X-ray (no clinical evidence) ...

Recovers.

The End.

Finally, why? Why do we have to deal with this virus at all?

The media would prefer if you would stop asking this question, but Americans who didn’t have to die are dead because of Wall Street’s decision to merge our economy with the Chinese, who have unusual eating habits.

The Chinese eat wolf pups. But eating dog wasn’t weird enough. It didn’t give them a frisson of freakishness. They also eat bats, snakes and chicken testicles.

Husband: Oh, honey, golden retriever again?

[Kids groan]

Mom: Not tonight! For a special treat, we're having chicken testicles!

Kids: Aw, you're the best mom ever!

Tigers and rhinos are the most endangered species on Earth because Chinese people think rhinoceros horns and tiger penises can cure impotence. The Caspian, Bali and Javan tigers are already extinct because of this charming folk remedy.

Recently added to the endangered species list is the cute, cartoonish pangolin, the most trafficked animal is the world. Unfortunately, the pangolin’s scales are believed to cure any number of ailments, according to traditional Chinese medicine.

Where’s PETA?

The media are too busy covering for China. At least the Chinese aren’t white.

Although, it occurs to me that, despite America’s terrible toxic whiteness, one way our culture is superior to others is that we don’t believe lunatic nonsense that wipes out entire species or launches viral pandemics on the world.

Now back to Chris Cuomo’s riveting battle with the coronavirus.

SOURCE 
http://www.anncoulter.com/columns/2020-04-08.html

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Curve Ball: The Worst-Case COVID-19 Scenario Was Just Dramatically Cut by Modelers

The Institute for Health Metrics and Evaluation at the University of Washington in Seattle has just revised down its COVID-19 worst-case scenarios for the country.

One of the projected next hotspots, California, is projected to need only half the ICU beds, ventilators and critical hospital equipment than originally predicted because there will be many fewer COVID-19 cases, according to IMHE. All of the state's supplies are on hand, according to the survey.

IMHE has revised down the number of expected COVID-19 deaths from 6,100 to 1,783 in California.

The state's peak for the worst number of deaths originally was expected to be at the end of April; now it appears it will be mid-April.

While the modeling has been updated daily since being published, the latest numbers reveal a somewhat dramatic shift from just six days ago — the reflection of “a massive infusion of new data,” Dr. Christopher Murray, the institute’s director, said in a news release.

“As we obtain more data and more precise data, the forecasts we at IHME created have become more accurate,” Murray said.

Across the U.S., there will also be less of a need for hospital and ICU beds to deal with the outbreak than earlier figures showed, according to the institute. But there will still be an estimated shortage of roughly 36,654 hospital beds, including 16,323 ICU beds.

The nation's peak of deaths from COVID-19 is expected on April 16th with a projected 3,130 deaths.

The effort everyone has made to socially distance to flatten the curve is working. We'll see if the economic devastation the country has suffered in service to this has been worth it or a historical curveball.

SOURCE 

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IN BRIEF

After 76 days in lockdown, the Chinese city at the heart of the global pandemic reopened Wednesday and tens of thousands immediately hopped on trains and planes to leave (AP)

New York virus deaths hit new high, but hospitalizations slow (The New York Times)

NYC data: Vast majority who have died from COVID-19 had serious underlying conditions (The Daily Wire)

On top of being a bureaucratic train wreck, $350 billion for the Paycheck Protection Program wasn't enough, Congress says, racing to send billions more to small businesses (Politico)

"We have a lot of IGs in from the Obama era": Trump removes inspector general who was to oversee $2 trillion relief spending (The Washington Post)

An awkward, experimental Democrat primary in Wisconsin (Washington Examiner)

Trump says U.S. may put a "very powerful hold" on funding to communist-supporting World Health Organization (Fox News)

Instead of helping workers on furlough, leftist groups spend more than $20 million attacking Trump, GOP on coronavirus (The Washington Free Beacon)

Acting Navy Secretary Thomas Modly resigns after suggesting ousted captain was "stupid" for writing letter (National Review)

How many more evaded inspectors? Border Patrol stopped a Chinese biologist carrying viable SARS, MERS viruses at Detroit airport in 2018 (National Review)

The coronavirus pandemic is not stopping border-wall construction (The Daily Caller)

For the record: China's long tentacles extend deep into American media (The American Conservative)

Enabling the lawbreakers: Chicago mayor signs executive order to ensure illegal immigrants can access relief funds (National Review)

Why weren't they replaced? Michael Bloomberg's emergency ventilator stockpile in New York City ended up on the auction block (ProPublica)

Larry Kudlow: We're looking to open economy in four to eight weeks (The Daily Wire)

Getting out of Dodge: New data shows U.S. companies are definitely leaving China (Forbes)

Observations: "There isn't much point in trying to talk rationally to a guy in an asylum who thinks he is Napoleon. Likewise, there probably isn't much point in trying to talk rationally to a Democratic politician or activist in 2020 America." —John Hinderaker

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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Thursday, April 09, 2020



9 April, 2020

Drug Is Safe and Sometimes Works, Let All COVID-19 Patients Take It

In mid-March a Palo Alto, California, woman’s COVID-19 worsened to pneumonia while being treated at Stanford Hospital. She had already suffered from asthma and diabetes.

In a trial, doctors decided to give her the drug remdesivir, which has been well established as safe and used to treat Ebola. It worked; she’s now home recovering wonderfully.

The outstanding question is: Is it helpful for COVID-19? The answer is: Yes, at least for some coronavirus victims.

So why not let the drug be given to all COVID-19 patients rather than just in trials, as was the case with the Palo Alto woman’s trial? They have everything to gain and nothing to lose. The drug sometimes cures pneumonia and possibly prevents it in the first place.

Governmental medical science, tragically, does not work this way. The Food and Drug Administration requires that, before a drug can be prescribed, it must clear three sets of clinical trials to prove that it is safe and effective; that usually takes a year.

COVID-19 patients usually have anywhere from a few days to a few weeks to live or die. Why can’t patients with the coronavirus take remdesivir to see if it helps?FDA approval for efficacy is largely pointless.

I learned of this sad FDA policy the hard way. I was on the board of the Abigail Alliance that sued the FDA when a terminal cancer patient was denied the right to experimental drugs even though the FDA had found the them clinically safe and promising.

Our argument was that if we have a constitutional right to defend ourselves against an attacker, why can’t we have that same right of self-defense when the attacker is cancer? I based this logic on my own wife’s experience: she had terminal lung cancer and was given an experimental drug that extended her life and eliminated her chronic pain.

Our case was heard in the D.C. Circuit Court of Appeals on August 7, 2007. We lost and would likely lose today because the FDA still mandates three clinical trials to prove drugs safe and effective.

Dr. Anthony Fauci of the National Institute of Allergy and Infectious Diseases cites frequently the necessity of this three-clinical-trial process referring to any other drug cure of the coronavirus as merely “anecdotal.”

Judge Judith Rogers supported our case and pointed out a cruel irony: In rejecting our appeal to extend cancer patients’ lives, said the judge, “the right to try to save one’s life is left out in the cold despite its textual anchor in the right to life.”

Chief Judge Douglas Ginsburg also supported our case. He argued: Do we have a constitutional “right to eat meat” when the Constitution is silent on the matter?

It is silent on drugs, which does not mean that we can’t take them. It is a right we are given by the Ninth Amendment: “The enumeration in the Constitution, of certain rights, shall not be construed to deny or disparage others retained by the people.”

It is tragic that a patient with COVID-19 and pneumonia or difficulty breathing cannot be given the remdesivir, which is safe and, in some cases, effective.

It sent the Palo Alto woman home rather than to the morgue.

SOURCE  

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Coronavirus Deaths Will Be 'Much, Much, Much Lower' Than Predicted Models, Says Head of CDC

In the ever-changing contradictory nature of information during the pandemic age, the head of the CDC, Robert Redfield, told listeners of Arizona's 1030 KVOI radio he believes there's good news ahead. Redfield said the death toll from the Chinese COVID-19 will be "much, much, much lower" than the models have predicted. “If we just social distance, we will see this virus and this outbreak basically decline, decline, decline. And I think that's what you're seeing,” he said.

The models the White House is using projected the deaths of between 100,000 and 240,000 Americans. Redfield says models aren't the end of the story. "Models are only as good as their assumptions, obviously there are a lot of unknowns about the virus,” he said. “A model should never be used to assume that we have a number.”

He continued to praise the American people for taking the social distancing seriously, saying, "I think that's the direct consequence of why you're seeing the numbers are going to be much, much, much lower than would have been predicted by the models."

Redfield has vociferously approved of the social distancing measures taken by the federal and local governments.

SOURCE  

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Dem Lawmaker in Detroit Says Hydroxychloroquine and Trump Helped Save Her Life

State Rep. Karen Whitsett, a Detroit Democrat, tested positive for the coronavirus last month. Now, she's crediting hydroxychloroquine and Donald Trump with saving her life.

President Trump has been touting hydroxychloroquine as a potential game-changer since mid-March after small studies showed it potentially served as an effective treatment for coronavirus patients. “I feel good about it. Just a feeling. I am a smart guy, we’ll see soon enough and we have certainly big samples of people,” Trump said at the time. The media was quick to pounce on Dr. Anthony Fauci's reluctance to fully endorse the drug because there had not been a clinical trial of hydroxychloroquine for coronavirus yet. Hydroxychloroquine has long been approved by the FDA as an antimalarial drug.

Whitsett was prescribed hydroxychloroquine, and she said she felt relief from her symptoms in less than two hours. She had experienced shortness of breath, swollen lymph nodes, and what felt like a sinus infection.

Boston Globe Editorial Board Claims Trump Has 'Blood on His Hands'
Whitsett had been aware of  "the wonders" of hydroxychloroquine after a previous Lyme disease affliction, but, the Detroit Free Press reports, "does not believe she would have thought to ask for it, or her doctor would have prescribed it, had Trump not been touting it as a possible treatment for COVID-19." Whitsett says she's been taking the drug in combination with antibiotics.

"It has a lot to do with the president ... bringing it up," Whitsett said. "He is the only person who has the power to make it a priority."

When asked by the Detroit Free Press whether she thinks Trump may have saved her life, she replied. "Yes, I do," and "I do thank him for that."

President Trump responded to the story on Monday, "Congratulations to State Representative Karen Whitsett of Michigan. So glad you are getting better!"

The media has desperately tried to undercut Trump's positive message about hydroxychloroquine's potential as a treatment for the coronavirus, calling it "unproven" and claiming there's "no proof" that it works. The New York Times even alleged that Trump's motivation for touting the drug was self-serving because he holds “a small personal financial interest” in Sanofi, the company that makes a brand name version of hydroxychloroquine, even though the drug's patent is expired and any pharmaceutical company can manufacture their own generic versions of it. Even New York governor Andrew Cuomo conceded that “There has been anecdotal evidence that it is promising."

SOURCE  

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Setting a 'D-Day' to Restart the American Economy



Much is being said these days about how the two-week period of April 5-19 is expected to experience a peak in coronavirus (COVID-19) deaths. This prediction applies to the city of New York as well as certain other cities and areas of the United States.

Concurrent with the above time period and continuing thereafter, the nationwide supplies of essential face masks, protective clothing, ventilators, protective gloves, and other needed medical supplies to combat the virus are exponentially mushrooming. As of the last week in April, there should be little or no scarcity of the above items to treat dangerously infected Americans, no matter where they live. Furthermore, by the end of April, one or more therapies will most likely receive greater approval as effective treatments against COVID-19.

It is well known that the president and state governors have a delicate balancing challenge. On the one hand, they must consider COVID-19 death rates. On the other hand, they must consider the ongoing tremendous damage and harm being done to the mental and physical health of millions of Americans who have suddenly lost jobs, lost savings, become bankrupt, or otherwise are experiencing severe mental anxiety, hopelessness, and/or depression.

The effects of the COVID-19 pandemic thus far rightfully have concentrated on the number of people infected, recoveries, and deaths. Largely overlooked, however, are predictions that the ultimate death toll from the pandemic could be higher due to job losses, bankruptcies, lost savings, and containment/mitigation efforts than from the actual virus itself.

It is well established that unemployed individuals often suffer from loss of self-esteem and a sense of shame, humiliation, or despair. They may suffer from hopelessness, depression, and social isolation, which are all serious risk factors for suicide.

Given the above, this article suggests that in order to establish a degree of certainty, and absent any further catastrophic event(s), President Trump and his administration should designate a day in May as the target day — D-Day, if you will — for America’s $22 trillion economy to be “back in business.” A possible date to consider is May 12, which happens to be the 75th anniversary celebration of the allied victory over Nazi Germany in Europe.

In taking this action, the president will, of course, need to defer actual implementation to the governors of the 50 states according to their own assessments of their containment, mitigation, and recovery efforts in their respective states. But the president can set an example by, among other things, authorizing the opening of federal buildings and other facilities and services under his control.

The president’s decision and recommendation for when people should return to their jobs is similar in at least one important aspect to the decision General Dwight Eisenhower had to make concerning the launching of the Normandy invasion in June 1944. Both decisions revolve around life-and-death issues. Eisenhower knew that the allied death rate could be very high (many tens of thousands) if the invasion was unsuccessful, whereas President Trump understands that the number of COVID-19 deaths could be in the many hundreds of thousands if he acts too early or, conversely, too late. As with Eisenhower, President Trump ultimately must make his decision for all Americans, not just those who unfortunately happen to be directly in harm’s way.

No doubt many will say that the president is “between a rock and a hard place.” He will be criticized no matter when he eventually recommends that people return to their jobs even with the understanding that critical mitigation actions need to be maintained for the foreseeable future such as frequently washing hands, not touching one’s face, and maintaining a safe distance from another person.

Thus, Mr. President, please work with the state governors and push for the American economy largely to be “back in business” during May 2020. This senior citizen is more than willing to take responsibility for my own personal COVID-19 mitigation actions, as I am sure many others like me will do the same. Get the economy rolling again — soon.

SOURCE  

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IN  BRIEF

The steep rise in coronavirus deaths appeared to be leveling off Monday in hard-hit New York (AP)

Austria and Denmark are first in Europe to announce easing of lockdowns (The Washington Post)

Researchers lower fatality projections in model used by White House (The Daily Caller)

Trump approves USNS Comfort to treat New York patients (UPI)

Communist sympathizers at WHO demand abortion be considered "essential" healthcare services during pandemic (The Daily Wire)

Trump nominates White House lawyer Brian Miller to serve as Special Inspector General for Pandemic Recovery (The Daily Caller)

Pelosi says next stimulus boondoggle will be $1 trillion or more (Bloomberg)

"I appreciate his calling": Trump says he and Biden had a "warm conversation" about coronavirus (Washington Examiner)

Trump asks reporter if she's working for the Chinese government after pro-Beijing questions. Sure enough, her agency is a front for the CCP. (The Daily Caller)

Bring back Scott Walker: Wisconsin Supreme Court overturns governor's gamesmanship, orders Tuesday elections to proceed (Politico)

Hillary Clinton can't duck out of Benghazi testimony by citing official privilege, State Department says (PJ Media)

"He made a mistake": Trump urges Navy not to "destroy" captain who wrote coronavirus letter (Washington Examiner)

Rise in searches for "How to set fire" a sign insurance fraud beckons as economy crashes (Washington Examiner)

Auto insurers rightfully refunding millions due to stay-at-home policies (Fox News)

District court upholds closing of Los Angeles-area gun shops (The Volokh Conspiracy)

Policy: How the Left is trying to blame capitalism for COVID-19 deaths (Mises Institute)

Satire: The Bidens still don't know how many grandchildren they have (The Washington Free Beacon)

For the record: "More people will die, even in the worst projections, from cigarette smoking in this country than are going to die from coronavirus this year." —U.S. Surgeon General Jerome Adams

Food for thought: "Our national media is ROOTING for hydroxycloroquine to not work as a treatment for #Covid_19. Think about that." —Matt Mackowiak

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCHPOLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is hereHome page supplement

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