Vaccine 'by September'

Britain will get first access to a coronavirus vaccine being developed by Oxford University with pharmaceutical giant AstraZeneca poised to make 30 million for the UK by September - if it works.

Alok Sharma, the Business Secretary, today announced a deal has been done between the university and the company to manufacture the vaccine which is currently in clinical trials.

He pledged an additional £84 million to accelerate the development of the vaccine - on top of a previous £47 million pot of cash - so that mass production can start as soon as possible if it is proved to be effective.

Mr Sharma said the Oxford project is 'progressing well' and that another vaccine effort by Imperial College London is 'also making good progress'.

However, he cautioned that despite the growing optimism there are 'no certainties' and there may never be a vaccine developed capable of tackling the deadly disease.

Mr Sharma also revealed that six drugs designed to treat coronavirus have now entered initial live clinical trials. The world is yet to identify a drug clinically proven to treat the disease.

The COVID-19 trials are taking place at the Churchill Hospital in Oxford and started on April 23. A second vaccine from Imperial College London is also hoped to face human trials in June. 

A working vaccine is viewed as likely the only surefire way for the world to go back to something resembling normal life.

Mr Sharma last month announced the creation of a new vaccine task force to bring together the Government, universities and industry in the hope that the UK could lead the way in developing a vaccine.

The Business Secretary said he was 'very proud' of how quickly different sectors had united for the 'critical mission' with the Oxford and Imperial programmes emerging as 'two of the world’s frontrunners'.

The Oxford vaccine is now in its first clinical trial and all phase one participants have now received their vaccine dose and are being monitored by the clinical trial team. 

Mr Sharma said: 'The speed with which Oxford University has designed and organised these complex trials is genuinely unprecedented.

‘Imperial College are also making good progress and will be looking to move into clinical trials by mid-June with larger scale trials planned to begin in October.

‘So far the Government has invested £47 million in the Oxford and Imperial vaccine programmes. ‘But today I can announce an additional £84 million of new Government funding to help accelerate their work.

‘This new money will help mass produce the Oxford vaccine so that if current trials are successful we have dosages to start vaccinating the UK population straight away.

SOURCE 

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‘There is nothing unprecedented about the virus itself’

Lionel Shriver on the hysteria driving the worldwide Covid shutdown



The ‘new normal’ of lockdowns, social distancing and economic catastrophe has been greeted with remarkably little resistance. The novelist Lionel Shriver is a rare dissenting voice. In the language of coronavirus, she proclaims to have ‘immunity’ from the ‘herd’. She joined spiked editor Brendan O’Neill for the latest episode of The Brendan O’Neill Show. What follows is an edited extract.

Brendan O’Neill: You have talked about the supine capitulation to a police state that has happened in the UK over the past few weeks. Do you think things are that bad? Do you think it is not only so bad that we have a police state, but it is even worse because everyone has capitulated to it in a rather craven fashion?

Lionel Shriver: I think it’s pretty impressive. I have come across, in more than one article, references to how ‘free thinking’ and ‘independently minded’ British people are supposed to be, and I don’t think that this situation bears that out. There has been research into the English attitude to authority. The English, in particular, capitulate to authority. They obey the law for the law’s sake. This runs completely counter to my own inclinations, because I’m afraid I have a very deep-set ‘fuck you’ impulse. I don’t like being told what to do, and most of all I want people to justify it when they tell me what to do. I don’t do things just because of the law. I do them because they are the smart and right things to do. There has not been enough questioning on the public’s part, especially as to whether or not these lockdowns are even epidemiologically sensible.

O’Neill: Why does the lockdown not add up, in your view?

Shriver: I don’t think it makes a lot of sense once the virus has spread generously in the population already. There is plenty of evidence that the virus does continue to spread, even if you do have a lockdown. What we are doing is dragging the period of infection out. A lot of epidemiologists will back that up. Rather than reducing the absolute number of infections and absolute number of deaths, you simply make them occur over a longer period of time. You could argue that is actually socially destructive. As long as your healthcare system can handle a higher rate of infection – which our NHS could do right now – then it’s probably better to get it over with.

O’Neill: One thing that you have raised is the absence of critical voices in the mainstream media. As you point out, there are actually epidemiologists who believe that the idea that you can lock a disease away in a cupboard and make it disappear is complete idiocy and is completely unworkable and only puts off the inevitable, which is that the disease will become part of the family of diseases. Those voices are not being heard as much as they might be, and certainly not with parity to the other, more terrifying voices. What have you made of the broader media culture around this discussion of the virus and the lockdown?

Shriver: The media are worse than the public. Of course, the media are also controlling the public to a degree. I have been especially appalled by how few dissenting voices ever appear on television. I force myself to suffer through news programmes on a nightly basis, and I was really struck recently by Channel 4. This was not even a story, it was just a little statistic that they flashed up on the screen. It was that we are expecting 1.5 billion people – which is, they were careful to clarify, half the workforce of the entire world – to have no source of livelihood. That was just a little fact. Then we went back to the situation in care homes in the UK, which took up most of the rest of the broadcast. It’s as if it was incidental. This never gets any attention.

Nor does any dubiety among the scientific community about the wisdom of treating this disease completely differently to how we treat any other disease. Nor do I ever see any comparative statistics aired on television news – and you rarely find them in newspapers, either – putting the deaths in context, both in the context of how many people die every year in certain countries and worldwide anyway, and also of how many people die of other diseases routinely.

In 2017, the number of people who died of malaria was 620,000. That is almost all in Africa. We totally ignore it. That’s three times the number of people who’ve died of Covid-19 so far worldwide. But it’s just ordinary. They live with it. In 2018, 1.5million people died of tuberculosis. And TB is especially dangerous because it’s developing a resistance to our treatment to it. So it’s actually more terrifying than Covid-19. Again, we forget about it. Typhoid, which we think of as a disease of the past, still kills up to 160,000 people a year. Cholera is the same – it kills about 140,000 people a year. Influenza, which Covid resembles in many ways, kills up to 650,000 people every year. It took me five minutes to find those statistics. Why don’t I ever see them reported?

O’Neill: I want to go back to a point you made there about the incidental nature of the unprecedented economic collapse that the world is heading for. I have noticed that too; that in the media and in lots of political discussions, the predictions of a historically unprecedented contraction of economic life are treated either as incidental, or as significantly less important than Covid-19 itself. You give the example of 1.5 billion people losing their livelihoods in some way. Of course, in the UK, it is now being predicted that this will mean a 13 per cent drop in national output, which will be the largest contraction ever recorded. Why do you think that stuff is being pushed aside? Part of me thinks it’s some kind of Covid-related madness in which the media cannot see the broader picture. Or do you just think they cannot let anything get in the way of the politics-of-fear narrative that they are currently pushing?

Shriver: Madness is the word, but it is a shared hysteria. We are dealing with an international hysteria. You hear that word ‘unprecedented’ all the time. There is nothing unprecedented about the virus itself. It is very much like lots of other viruses and lots of other illnesses. In fact, it is less deadly than many other illnesses that we have had to learn to live with – some of which we have cured.

What is unprecedented is our reaction. And it’s the reaction that is causing the inevitable economic depression – or collapse, even. That is the level of economic failure we are dealing with. But it is as if the disease has caused the collapse. All that economic fallout is seen as simply the inevitable fallout of this terrible illness. But it has nothing to do with the illness. It has everything to do with our reaction to it. We have never done this before. We have never said we must close whole countries because of a contagious disease.

With these kinds of contagious diseases, you cannot just wait. If you are going to wait for it to not be there anymore, you are going to wait forever. That is what is really dangerous about the government’s change of strategy. It used to call for flattening the curve to save the NHS. And then as soon as we saved the NHS, we were still in lockdown. A new purpose for the lockdown was found, instead of ending it once it achieved its purpose.

Of course, the other thing that has happened is that the people have been so successfully brainwashed that it is getting very difficult to un-brainwash them. So it’s going to be difficult to get people to go back to work. It’s one thing to open restaurants again, it’s another thing to convince people that they want to go out to eat.

Furthermore, these new laws look as if they are going to be virtually indefinite. Many of these laws are going to make it impossible to run a successful business – if the business is even allowed to open. If you have a restaurant in which everyone has to be two metres apart, then how do you serve enough people to pay your staff and pay your chefs and pay your food bill and, most of all, pay your rent? The whole model is not going to stack up. You can’t spread people out too much, the facilities don’t allow for it. And therefore, it cuts your productivity so much that you cannot make any money. Everyone is just dealing with all of these measures as if they are inevitable, as if it’s just too bad, and it’s the fault of the virus. No, it isn’t. It’s the fault of the rabid overreaction to the virus.

O’Neill: Do you think there is a class or cultural component to that blindness of the lockdown fanatics to the consequences of the decisions that they are taking and the actions that they are pushing through? We know from the experience of recent years that we live under elites that are cut off from ordinary people’s lives and beliefs. Do you think there are some sections of society who are rather enjoying the lockdown because they can carry on working from home and the Deliveroo guys will still bring them their food? They live in nice houses and their blindness to the consequences of what they are doing or what they are supporting seems to be driven by their distance from people who have to work and have to mix together and have to make a living.

Shriver: I do think there is a segment of the population that is having a wonderful time, especially people who are being paid 80 per cent of their salaries. The irony being, of course, that they are paying themselves 80 per cent of their salaries. It’s taxpayers’ money. These are the same people who are heavy taxpayers, so they are going to end up having to pay their own furloughed salaries in future.

I think for some people, this has turned into a kind of indefinite holiday. You do not have to work very hard. You do not have to get dressed for work. You can stay in your pajamas. You can sit in front of the computer and feel self-righteous about it. Right now, being incredibly lazy and unproductive is patriotic. It’s the best of all possible worlds. In this sector, it is going to be hard to go back to normal, especially now that we are constantly informed that we cannot go back to normal. There is going to be a so-called ‘new normal’ – one of those expressions that we all now have learned to hate.

O’Neill: In terms of the economy, one of the striking ways in which people justify their blindness to this situation, or justify the acceptability of what is about to occur, is by making this very shallow propagandistic distinction between lives and the economy. You will know from personal experience that anyone who questions the lockdown or the reaction to the virus is depicted as caring more about the economy than lives, caring more about profit than lives, hating old people and so on. But to make a distinction like that between how people live and economic life is completely false, right?

Shriver: I think it is self-evident. [We] cannot have a country without an economy. What is abstract about an economy is the word. An economy is anything but abstract. It is all the very literal, tangible things we do between ourselves that make high-density living possible. If we do not have an economy, we cannot have a city – we would all be grubbing on our own little patch of dirt trying to raise a stalk of corn. When we are doing that all by ourselves, then there is no economy. But if we want to go to the supermarket to get popcorn, there has to be an economy. This whole idea that you can shelter human life and throw the economy into the toilet is patently ludicrous.

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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Blood-thinning drugs can help save the lives of coronavirus patients by stopping dangerous clots forming on the lungs, British scientists discover

London specialists made the discovery after finding Covid-19 caused potentially deadly blood clots in the lungs of most patients who die.

NHS England will give hospitals new guidance on blood thinning, which may lead to the administration of higher doses for those who are critically ill.

Specialists at the Royal Brompton Hospital's severe respiratory failure service identified the clearest link yet between Covid-19 and clotting.

They used hi-tech dual energy CAT scans to take images of lung function in the worst patients - which found a lack of blood flow, suggesting clotting within the small vessels in the lung. 

This may explain why some patients die of lung failure through lack of oxygen in the blood, doctors told The Sunday Telegraph.

Low oxygen levels have been regularly recorded in Covid patients reporting no breathlessness.

Prof Openshaw, a specialist in experimental medicine at Imperial College London told the publication: 'This intravascular clotting is a really nasty twist that we haven't seen before with many other viruses.

'It does sort of explain the rather extraordinary clinical picture that is being observed with people becoming very hypoxic, very low on oxygen and not really being particularly breathless. That would fit with it having a blood vessel origin.'

As a result of the new evidence, clinical trials to test blood-thinning drugs are being fast-tracked as part of the Government's response to the pandemic. 

The new NHS England guidance is independent of the work, and is believed to have been issued on the advice of haematology specialists.

Doctors at the Royal Brompton said blood thinning medication should be used carefully and specialists have said treatment would need to 'start very early' to prevent clots forming.

Dr Brijesh Patel said she thinks the majority of patients will end up on 'significant therapeutic doses' of blood-thinning drugs as scientists learn more about the disease, and if implemented properly they will save lives.   

SOURCE 

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Delaying herd immunity is costing lives

The current lockdown is protecting the healthy instead of the vulnerable.

Climate scientists are frustrated by people who do not believe in climate change. In epidemiology, our frustration is with anti-vaxxers. Most anti-vaxxers are highly educated but still argue against vaccination. We now face a similar situation with ‘anti-herders’, who view herd immunity as a misguided optional strategy rather than a scientifically proven phenomenon that can prevent unnecessary deaths.

Because of its virulence, wide spread and the many asymptomatic cases it causes, Covid-19 cannot be contained in the long run, and so all countries will eventually reach herd immunity. To think otherwise is naive and dangerous. General lockdown strategies can reduce transmission and death counts in the short term. But this strategy cannot be considered successful until lockdowns are removed without the disease resurging.

The choice we face is stark. One option is to maintain a general lockdown for an unknown amount of time until herd immunity is reached through a future vaccine or until there is a safe and effective treatment. This must be weighed against the detrimental effects that lockdowns have on other health outcomes. The second option is to minimise the number of deaths until herd immunity is achieved through natural infection. Most places are neither preparing for the former nor considering the latter.

The question is not whether to aim for herd immunity as a strategy, because we will all eventually get there. The question is how to minimise casualties until we get there. Since Covid-19 mortality varies greatly by age, this can only be accomplished through age-specific countermeasures. We need to shield older people and other high-risk groups until they are protected by herd immunity.

Among the individuals exposed to Covid-19, people aged in their 70s have roughly twice the mortality of those in their 60s, 10 times the mortality of those in their 50s, 40 times that of those in their 40s, 100 times that of those in their 30s, and 300 times that of those in their 20s. The over-70s have a mortality that is more than 3,000 times higher than children have. For young people, the risk of death is so low that any reduced levels of mortality during the lockdown might not be due to fewer Covid-19 deaths, but due to fewer traffic accidents.

Considering these numbers, people above 60 must be better protected, while restrictions should be loosened on those below 50. Older people who are vulnerable should stay at home. Food should be delivered and they should receive no visitors. Nursing homes should be isolated together with some of the staff until other staff who have acquired immunity can take over. Younger people should go back to work and school without older coworkers and teachers at their sides.

While the appropriate magnitude of countermeasures depends on time and place as it is necessary to avoid hospital overload, the measures should still be age-dependent. This is how we can minimise the number of deaths by the time this terrible pandemic is over.

Among anti-herders, it is popular to compare the current number of Covid-19 deaths by country and as a proportion of the population. Such comparisons are misleading, as they ignore the existence of herd immunity. A country much closer to herd immunity will ultimately do better even if their current death count is somewhat higher. The key statistic is instead the number of deaths per infected. Those data are still elusive, but comparisons and strategies should not be based on misleading data just because the relevant data are unavailable.

While it is not perfect, Sweden has come closest to an age-based strategy by keeping elementary schools, stores and restaurants open, while older people are encouraged to stay at home. Stockholm may become the first place to reach herd immunity, which will protect high-risk groups better than anything else until there is a cure or vaccine.

Herd immunity arrives after a certain still unknown percentage of the population has acquired immunity. Through long-term sustainable social distancing and better hygiene, like not shaking hands, this percentage can be lowered, saving lives. Such practices should be adopted by everyone.

Social distancing that cannot be permanently sustained is a different story. Some people will eventually be infected, and for every young low-risk person avoiding infection, there will ultimately be roughly one additional high-risk older person that is infected, increasing the death count.

Anti-vaxxers do not suffer the consequences of their beliefs, as they are protected by the herd immunity generated by the rest of us. Neither will the anti-herders, many of whom can afford to isolate themselves from Covid-19 until natural herd immunity is achieved by others. It is older and working-class people that disproportionately suffer from the current approach, becoming infected and thereby indirectly protecting much lower-risk college students and young professionals who are working from home.

The current one-size-fits-all lockdown approach is leading to unnecessary deaths. Protecting older people and other high-risk groups will be logistically and politically more difficult than isolating the young by closing schools and universities. But we must change course if we want to reduce suffering and save lives.

SOURCE 

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How coronavirus spreads, and why some are spared – and others not

New study analysing dozens of actual Covid-19 clusters from around the world shows enclosed spaces are hotbeds of the virus

Risk of coronavirus infection is much higher within households or other enclosed environments in which contact is close and sustained

Almost every day now, a new study is published that shines light on the way in which the new coronavirus is spread. It will be years before the precise dynamics of transmission are nailed down, but the broad outline of how the disease moves is becoming clear.

The latest findings come not from epidemiological estimates but from analysis of dozens of actual Covid-19 clusters unpicked by contact and trace teams from around the world. These studies are like a forensics report from a crime scene. While a good psychological profiler can point detectives in the right direction, the CSI team gives them the smoking gun.

An analysis of such studies was recently posted on Twitter by Dr Muge Cevik, an infectious diseases clinician and researcher from St Andrews University. It was promoted by Sir Jeremy Farrar, the head of the Wellcome Trust and a member of the Scientific Advisory Group for Emergencies (Sage). "If you read one thread,make it this one," Sir Jeremy said.

Dr Cevik starts with a big Chinese study that traced 2,147 close contacts of 157 confirmed Covid-19 cases. The overall infection rate was six per cent, but it was much higher among friends (22 per cent) and family members (18 per cent). In terms of location, the main risk factors were homes (13 per cent) transport (12 per cent) and dinner and entertainment (seven per cent).

Broadly similar findings emerge in several other papers. Risk of infection is much higher within households or other enclosed environments in which contact is close and sustained. In the outdoors, it falls to something in the 0-5 per cent range.

Transmissibility also appears to be impacted by age and the type of relationship people have with one another. A Chinese study of 392 contacts of 105 confirmed cases found that the attack rate in children was just four per cent within the home, compared with 17.1 per cent in adults, for example. The infection of spouses was super high, at 28 per cent.

Emphasising the link with age, another study found that household members over 60 were much more likely to become infected (18 per cent) than those under 20 (five per cent).

Children, it seems, are not only better able to resist the infection within the home but also less likely to bring it back with them. A study, funded by the Australian Research Council, of 31 household clusters including children found that only 10 per cent had been sparked by children.

"Whilst SARS-CoV-2 can cause mild disease in children, the data available to date suggests that children have not played a substantive role in the intra-household transmission of SARS-CoV-2," said the authors.

Using these and other studies, Dr Cevik concludes that they suggest (not prove) the following:

Close and prolonged contact is required for transmission of the virus.

Risk is highest in enclosed environments such as houses, care facilities, public transport, bars and other indoor spaces where people congregate.

Casual, short interactions are not the main driver of the epidemic.

Susceptibility to infection increases with age.

Dr Cevik does not look at how the virus passes from person to person, but plenty of other research suggests it moves in droplets expelled from the infected. Droplets may land directly on the mucus membranes of others (eyes, nose, mouth) or indirectly via shared surfaces (plates, desks, doorknobs). If the virus were truly airborne, household infection rates would almost certainly be far above 20 per cent.

Is this good or bad news for the Prime Minister, who is working hard this weekend on the UK exit strategy? And what sort of policies might it point to?

On the upside, it suggests lockdown can be relaxed with much less risk in outside spaces. In truth, Britain has been more liberal on this from the start than places like Spain, France and Italy, and the evidence suggests it can almost certainly go further. The trick will be to find mechanisms to stop people from inadvertently forming crowds by turning up at the same places at the same time.

The evidence also points to the power of good hygiene. Household attack rates are high, at 20 per cent – but that leaves 80 per cent who escape despite living under the same roof. There is some evidence that UK infections started to fall ahead of lockdown because of hand-washing and other hygiene messages. These should almost certainly be ramped up again, and extended. Think hand-cleansing facilities at every doorway, public or private.

On the downside, our winters are cold and wet, forcing us to congregate inside. Dr Cevik says this points to the need to "redesign our living and working spaces and rethink how to provide better, ventilated living and working environments for those who live in deprived and cramped areas". That will be a hard task, but an essential one.

It is winter that the Government will be most worried about. It can give us some outdoor freedom now, but it knows that won't mean much beyond September. The NHS also comes under much greater strain in winter, and Covid-19 symptoms will become harder to detect when mixed with flu and winter sniffles.

Ministers will therefore want to do everything possible now to drive down the virus to levels at which contact tracing teams can keep it in abeyance before winter arrives. Anything else and they risk a second major outbreak two to three months after the nights draw in.

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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Neurosurgeon Says Face Masks Pose Serious Risk to Healthy People

Every Karen on Facebook is shaming her neighbors for not wearing a face mask. We are being told by governors that if we don’t wear masks we are selfish, horrible human beings with no souls who want Grandma to die a horrible death. Police are tackling people who don’t wear face masks properly in the subway. Grocery stores are throwing maskless people out and denying them service.

But now, there’s another doctor weighing in—besides Dr. Fauci, bonafide sex god and ruler of us all, who also said face masks are largely security theater and of no use to the healthy. Dr. Russell Blaylock, a neurosurgeon, has written an editorial saying that “masks pose serious risks to the healthy.”

First, Blaylock says, there is no scientific evidence that masks are effective against COVID-19 transmission. Pro-science people should care about this.

As for the scientific support for the use of face mask, a recent careful examination of the literature, in which 17 of the best studies were analyzed, concluded that, “ None of the studies established a conclusive relationship between mask/respirator use and protection against influenza infection.”   Keep in mind, no studies have been done to demonstrate that either a cloth mask or the N95 mask has any effect on transmission of the COVID-19 virus. Any recommendations, therefore, have to be based on studies of influenza virus transmission. And, as you have seen, there is no conclusive evidence of their efficiency in controlling flu virus transmission.

It is also instructive to know that until recently, the CDC did not recommend wearing a face mask or covering of any kind, unless a person was known to be infected, that is, until recently. Non-infected people need not wear a mask. When a person has TB we have them wear a mask, not the entire community of non-infected. The recommendations by the CDC and the WHO are not based on any studies of this virus and have never been used to contain any other virus pandemic or epidemic in history.

Beyond the lack of scientific data to support wearing a mask as a deterrent to a virus, Blaylock says the more pressing concern is what can and will happen to the wearer.

Now that we have established that there is no scientific evidence necessitating the wearing of a face mask for prevention, are there dangers to wearing a face mask, especially for long periods? Several studies have indeed found significant problems with wearing such a mask. This can vary from headaches, to increased airway resistance, carbon dioxide accumulation, to hypoxia, all the way to serious life-threatening complications.

There are studies to back that claim up.

In one such study, researchers surveyed 212 healthcare workers (47 males and 165 females) asking about presence of headaches with N95 mask use, duration of the headaches, type of headaches and if the person had preexisting headaches.

They found that about a third of the workers developed headaches with use of the mask, most had preexisting headaches that were worsened by the mask wearing, and 60% required pain medications for relief. As to the cause of the headaches, while straps and pressure from the mask could be causative, the bulk of the evidence points toward hypoxia and/or hypercapnia as the cause.

That is, a reduction in blood oxygenation (hypoxia) or an elevation in blood C02 (hypercapnia). It is known that the N95 mask, if worn for hours, can reduce blood oxygenation as much as 20%, which can lead to a loss of consciousness, as happened to the hapless fellow driving around alone in his car wearing an N95 mask, causing him to pass out, and to crash his car and sustain injuries.

I am sure that we have several cases of elderly individuals or any person with poor lung function passing out, hitting their head. This, of course, can lead to death.

A more recent study involving 159 healthcare workers aged 21 to 35 years of age found that 81% developed headaches from wearing a face mask. Some had pre-existing headaches that were precipitated by the masks. All felt like the headaches affected their work performance.

Blaylock says studies have also shown that face masks impair oxygen intake dramatically, potentially leading to serious problems.

The importance of these findings is that a drop in oxygen levels (hypoxia) is associated with an impairment in immunity. Studies have shown that hypoxia can inhibit the type of main immune cells used to fight viral infections called the CD4+ T-lymphocyte.

This occurs because the hypoxia increases the level of a compound called hypoxia inducible factor-1 (HIF-1), which inhibits T-lymphocytes and stimulates a powerful immune inhibitor cell called the Tregs. . This sets the stage for contracting any infection, including COVID-19 and making the consequences of that infection much graver. In essence, your mask may very well put you at an increased risk of infections and if so, having a much worse outcome.

In other words, if you wear a face mask and contract some sickness, you will not be able to fight it off as effectively as if you had normal blood oxygen levels. The mask could make you sicker. It could also create a “deadly cytokine storm” in some.

There is another danger to wearing these masks on a daily basis, especially if worn for several hours. When a person is infected with a respiratory virus, they will expel some of the virus with each breath.

If they are wearing a mask, especially an N95 mask or other tightly fitting mask, they will be constantly rebreathing the viruses, raising the concentration of the virus in the lungs and the nasal passages. We know that people who have the worst reactions to the coronavirus have the highest concentrations of the virus early on. And this leads to the deadly cytokine storm in a selected number.

How about cancer, heart attacks, and strokes? Blaylock says face masks can make all of those conditions worse.

People with cancer, especially if the cancer has spread, will be at a further risk from prolonged hypoxia as the cancer grows best in a microenvironment that is low in oxygen. Low oxygen also promotes inflammation which can promote the growth, invasion and spread of cancers. Repeated episodes of hypoxia has been proposed as a significant factor in atherosclerosis and hence increases all cardiovascular (heart attacks) and cerebrovascular (strokes) diseases.

If that’s not bad enough, how would you like COVID-19 in your brain?

It gets even more frightening. Newer evidence suggests that in some cases the virus can enter the brain. In most instances it enters the brain by way of the olfactory nerves (smell nerves), which connect directly with the area of the brain dealing with recent memory and memory consolidation. By wearing a mask, the exhaled viruses will not be able to escape and will concentrate in the nasal passages, enter the olfactory nerves and travel into the brain.

Why is it that we only listen to dire predictions from Dr. Fauci and we don’t consult other experts in the field of medicine? Is Anthony Fauci the only qualified person to talk about this virus? Furthermore, if he is, he agrees with Dr. Blaylock that only sick people should wear them and he said so on 60 Minutes. So why aren’t we listening to him?

SOURCE 



Stanford Antibody Studies Indicate No Safe Option for Eradicating COVID-19, Including Lockdown

Dr. Jay Bhattacharya of Stanford Medicine recently released his antibody study of the staff of 27 Major League Baseball (MLB) teams from across the nation. The study is of mostly staff, not players, and covered a broad demographic range. The results of the MLB study showed that only 0.7% of the staff had the antibodies indicative of having had COVID-19.

Some staff is located in areas where antibody testing has been conducted for the general population such as New York, Los Angeles, and Santa Clara. Most of these locations showed the MLB staff had a much lower rate of prior infection than the general population. For example, the New York City metro area showed 25% of the population had antibodies. The MLB staff for the Yankees only showed antibodies in 1.64% of the employees. The Mets tested positive at a rate of 2.61%.

Dr. Bhattacharya said this was indicative of a trend seen in the other studies he has done. Lower-income residents had higher exposure rates to COVID-19. While the MLB had put mitigation policies in place, he believes that middle-to-upper-income individuals, like most of these staff in this study, have lower exposure. The ability to work from home and live in areas away from where they work that are less densely populated may be a factor.

The conclusion that Dr. Bhattacharya comes to based on the studies he has done to date is that the epidemic is far from over. The good news is his studies show about 70% of those who display antibodies were asymptomatic. This testing also places the death rate at somewhere between 0.1- 0.5%. This is orders of magnitude lower than originally thought.

This is important because, according to Dr. Bhattacharya, containment strategies are not likely to be effective and the virus is not going to disappear:

“I think in the back of people’s heads there is this idea that somehow we can eradicate this disease if we just stay locked down. That is not possible. The serologic evidence, even the MLB study, suggest this. It suggests the epidemic is too widespread to eradicate. It spreads via asymptomatic contact. Like people who don’t have very many symptoms, even mild cold symptoms can spread the thing. They aren’t going to show up for testing. They aren’t going to show up at a hospital or a doctor.”

He said containment could actually backfire if a positive test requires forcible quarantine of the individuals and members of their households as some public officials are proposing. In these circumstances, he said people may begin to avoid testing. Then he added that lifting lockdowns will absolutely cause an increase in the spread of the illness. Lockdowns have simply delayed the full spread.

Dr. Bhattacharya is clear:

“There is no safe option. If you think that having a lockdown will provide you safety, you are mistaken. Because the problem is this lockdown has had enormous negative effects on the health of people in the United States and around the world.

For example, 1.4 million tuberculosis patients in India are not getting critical antibiotic treatments due to shutdowns. In the U.S., we know chemotherapy patients have missed treatments. Individuals have suffered heart attacks and strokes at home rather than go to the hospital, and mental health resources have seen staggering increases in calls. He also referenced the lagging deaths of despair that are likely, saying the current impacts will be larger than the 2008 recession.

Based on his research to date, Dr. Bhattacharya advocates for lifting lockdowns based on local experience data. His sense, though he has not confirmed via testing, is that this could be accomplished in most areas of the country. He also has some ideas of what the priorities need to be in proceeding, including widespread disease testing. He agreed with Dr. Fauci’s previous statement that disease testing is simply an answer at a point in time. A negative test does not confer any long-term assurance.

When asked, Dr. Bhattacharya clearly understood the political calculations that leaders are making. He said leadership is what is needed because politicians are going to face the consequences of COVID-19 or the problems caused by economic collapse. According to his assessment, a vaccine is an open-ended question. None of the other coronaviruses that infect humans have one and there is no guarantee this one will. So, he recommended the following:

Protect at-risk groups that are obvious such as nursing home residents. The disease most often seems to require some extended close contact to spread, so these environments need to be addressed.

Continue to share clinical information broadly. Ventilator protocols have improved significantly based on the sharing of best practices. This will result in more effective treatment.

Use the current global clinical information to determine more precisely who is at risk for severe illness with a COVID-19 infection.

He said the final bullet should be the focus for epidemiologists. For example, we know the elderly have a higher risk. But not all elderly patients suffer from severe disease. For those who suffered severe disease or death below the age of 65, what were their common health, demographic or genetic profiles? If researchers could refine this picture, then individuals and public health services could be advised appropriately.

SOURCE 

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IN BRIEF

FBI serves warrant, seizes phone of Sen. Richard Burr in stock sales investigation (USA Today)

Not good: Senate narrowly rejects plan to require a warrant for Americans' browsing data (TechCrunch)

House Republicans open inquiry into mysterious drone program officials use to police Americans who aren't social distancing (The Daily Caller)

FBI arrests NASA researcher for failing to disclose China ties (National Review)

Wisconsin Supreme Court invalidates state's stay-at-home order (Reuters)

Judge orders Massachusetts gun shops to reopen, but imposes unfair restrictions (PJ Media)

Los Angeles County announces new "safer at home" order with no end date (FOX 11)

Boy Scouts banned from planting American flags on veterans' graves for Memorial Day (Fox News)

Parkland cop, fired after school shooting, will get his job back (South Florida Sun Sentinel)

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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Media Lies: Democrat Governors Doing Great Jobs Despite Higher Virus Death Rates

What’s a Republican governor have to do to earn respect from the mainstream media? I’m asking because saving a lot of lives without totally trashing their state’s economy doesn’t seem to do the trick. Meanwhile, certain Democrat governors are portrayed as quietly competent heroes while having the worst infection and death rates in the nation.

AG Hamilton noted on Twitter earlier this morning:

Florida began its reopening process on Governor Ron DeSantis’ orders over a week ago, smartly putting retiree-heavy South Florida on a later, longer schedule. DeSantis also closed Florida much later than other states did — to media howls. Nevertheless, even though Florida has two million more people than New York does, and its population skews older than New York’s, New York has about eight times more COVID-19 cases than Florida has suffered.

Remember the Democrat attack ad from 2012, showing a Paul Ryan lookalike rolling a wheelchair-bound granny off a cliff? All Ryan had done was propose Medicare reforms. Democratic New York Governor Andrew Cuomo got thousands of grannies and grandpas killed with his March 25 directive ordering nursing homes to accept coronavirus patients. Cuomo even forbade nursing homes “from requiring a hospitalized resident who is determined medically stable to be tested for COVID-19 prior to admission or readmission.” The result was thousands of needlessly dead.

In a sane world with a nonpartisan media, DeSantis should be enjoying improved poll numbers, while New Yorkers ought to be gathered in front of the governor’s mansion with torches and pitchforks. And yet, Cuomo’s approval rating has shot up to 72% according to the latest from Quinnipiac. DeSantis, on the other hand, has seen his once-strong approval ratings decline over the last few weeks.

Despite Florida’s impressive COVID-19 numbers, compared to New York or New Jersey’s, the Washington Post felt the need to ask two days ago, “Does Florida Gov. Ron DeSantis know what he’s doing?“. If the New York Times gave a damn about its own city, they’d be demanding the heads of Gov. Cuomo and Mayor Bill DeBlasio. Instead, they’re running scare pieces on Florida with headlines like “‘Found Unresponsive at Home’: Grim Records Recount Lonely Deaths.” And Yahoo News felt the need to explain “How the coronavirus undid Florida Gov. Ron DeSantis.” The Wuhan Flu didn’t undo DeSantis; the mainstream media did.

Cuomo has recieved almost nothing but fawning press coverage, particularly from the Orange Man Bad crowd. Eddie Scarry wrote on Tuesday for the Washington Examiner:

So how are the media’s COVID-19 governor heroes doing? Daily press briefings by New York Gov. Andrew Cuomo, a Democrat, are run top to bottom live on cable news outlets, and his performances are cherished by the press. The New York Times last month called Cuomo’s delivery “articulate, consistent and often tinged with empathy.” The paper also likened the briefings to a “tender embrace.”

That soft hug, however, is currently accompanied by the shockingly high death rate of 139 per 100,000 people, a number that was boosted in part by Cuomo’s appalling decision to force nursing homes to accept any elderly person who had been infected with the virus. This directly exposed many high-risk people to the coronavirus and has probably resulted in many deaths.

Maryland Gov. Larry Hogan is a Republican, but he gets a lot of love from the press because he’s always ready to attack President Trump. His state isn’t doing so hot, either, with a rate of 28 deaths per 100,000. That means Maryland has a death rate more than twice that of Georgia.

New Jersey — where Democrat Phil Murphy is governor — has a population not much less than Georgia’s, yet has four times as many COVID-19 cases. I was unable to find a single negative MSM headline about Murphy in a week’s worth of stories from the mainstream media. The Republican governor of Georgia, Brian Kemp, has been given the same treatment as DeSantis, portrayed as a cross between a bumbler and a murderer. Kemp has been accused of “deadly ignorance,” and begged not to “risk virus’ resurgence here.” He even placed on a list of “The Definitive Ranking of the Worst U.S. Government Responses to the Coronavirus.”

But would you rather be a retiree with existing medical conditions in Kemp’s Georgia, or in Phil Murphy’s New Jersey? Would you feel safer on a Florida beach, or in a New York nursing home?

SOURCE 

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Republicans increasingly doubt Anthony Fauci but trust Donald Trump

Washington: At the beginning of the novel coronavirus outbreak - and for weeks afterwards - there was one thing Americans could seemingly agree upon: Anthony Fauci.

Today, that's considerably less the case. While Fauci retains the faith of a strong majority of Americans, opposition from Republicans has crept up steadily over the past month or so, as conservative media figures and politicians have increasingly called his advice into question.

Picking up that mantle in a particularly prominent way Tuesday was Senator Rand Paul, who spent his time at a hearing of the Senate Health, Education, Labor and Pensions Committee grilling Fauci and suggesting he shouldn't oversell his knowledge about what might become of the virus - along with Fauci's role in decisions about the response.

Paul pressed Fauci to admit he wasn't the "end-all" when it comes to the response, particularly when it comes to decisions about whether the economy should be reopened at this point.

Fauci offered a subtly pointed response. While noting that he had never presented himself as the "end-all" - Fauci has made a point to say that others are in charge of economic considerations - he repeated Paul's allusions to using "humility" in offering prescriptions about what might lay ahead.

Particularly, he pushed back on Paul's suggestion that schools could reopen because children suffer many fewer deaths from COVID-19 by saying people should be "humble" about what they don't know about how the virus impacts young people.

But Paul's line of questioning reflects an increasing conservative scepticism of Fauci - a scepticism that has grown over the past month in part thanks to people like him questioning Fauci's advice.

And a new poll this week reinforces that this scepticism is slowly taking hold: The CNN poll suggests a significant decline in GOP regard for Fauci's expertise when measured against other similar polls of Fauci in recent weeks.

While 84 per cent of Republicans said they trusted the information they received from President Donald Trump about the virus, just 72 per cent said the same about the Centres for Disease Control and Prevention, while just 61 per cent said the same about Fauci, the CNN poll found.

That split in regard for Trump and Fauci is something that simply didn't exist even a month ago.

A Fox News poll conducted in late March showed very little difference in GOP perceptions between the two. At the time, 85 per cent of Republicans approved of Fauci's handling of the coronavirus, versus just 8 per cent who disapproved. His plus-77 rating was about the same as Trump, for whom 86 per cent approved and 13 per cent disapproved (plus-73).

That gap, though, has progressively widened over the past month.

A Quinnipiac University poll in early April showed Republicans approved of Trump 89-10 and Fauci 77-8 - still sterling numbers for Fauci, but not quite on Trump's level.

By late April, a Gallup poll showed 91 per cent of Republicans approved of Trump on the virus, but just 71 per cent approved of Fauci.

Early this month, Republicans in a Washington Post-University of Maryland survey said Trump had done an "excellent" or "good" job on the coronavirus by a 79-21 margin (plus-58), as compared to 68-25 (plus-43) for Fauci.

And now, the CNN poll shows the biggest gap yet - at least on the narrower measure of trust. While Republicans trust Trump on the coronavirus by a margin of 84 per cent to 14 per cent (plus-70), they trust Fauci by less than half that margin, 61-29 (plus-32).

Trump has thus far declined to clash with Fauci publicly - apart from retweeting a call for his firing at one point in mid-April. But many of his allies in conservative media (and now the Senate) have been happy to pick up that torch and question Fauci's advice, as they push for a more aggressive reopening of the economy than Fauci has advocated.

And it seems to have gradually had the intended effect - even as Fauci, to date, retains a relatively strong image.

SOURCE 

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Social distancing not as effective as hoped, Minnesota modelling shows

Minneapolis: New modelling by Minnesota researchers of the COVID-19 pandemic showed that social distancing isn't as effective as initially expected in reducing deaths and infections, but will still help protect the state from a novel and highly infectious coronavirus.

Initial models were based on estimates that Minnesota's statewide stay-at-home order would reduce face-to-face contact and disease transmission by 80 per cent, but the new model released Wednesday showed it only reduced that by 59.5 per cent.

COVID-19 remains a new disease globally, and new understanding is helping to create a more precise model, said Stefan Gildemeister, state health economist, as he unveiled the new modelling results on Wednesday morning.

Initial estimates of the impact of social distancing in Minnesota were based on experiences in China, where the coronavirus first emerged. "Mitigation (in China) was very different from what we were experiencing here," Gildemeister said.

The modelling predicted roughly 1700 deaths in Minnesota by the end of May, but a range of 16,000 to 44,000 deaths over 12 months of the pandemic. That is higher than prior state modelling estimates, Gildemeister said, based on updated understanding of an earlier peak of the pandemic and broader spread of the virus in the state. "We hope these are pessimistic estimates, but it is certainly a plausible outcome," he said.

The latest model also was based on feedback from doctors that 100 per cent of people would die from COVID-19 if they needed ventilator care in hospitals to breathe and didn't receive it.

Minnesota hospitals have worked to increase ventilatory capacity in the past two months, and now have 3702 available - though 858 remain on back order. As of Wednesday, only 562 ventilators were in use statewide by patients with COVID-19 and other patients with medical problems unrelated to the pandemic.

Modelling of different scenarios showed that stay-at-home orders would reduce ventilator demand and deaths. A stay-at-home order through the end of May would cut in half the forecasted number of deaths compared to the state doing nothing at all from the start.

Modelling was instrumental early on in the pandemic for the state's governor Tim Walz, who issued school closures and statewide stay-at-home orders based in part on state-specific forecasts showing that COVID-19 cases would far outstrip the available supply of critical care beds and ventilators in hospitals.

The last model update was publicly unveiled on April 9. Walz has made key policy decisions in the absence of new forecasts - including another two-week extension of the stay-at-home order that is scheduled to end May 18.

More than 83,000 people have died in the US, representing more than one-fourth of global deaths and the world's highest toll. On the planet more than 4.3 million have been infected and about 295,000 have died.

Eager to restart the economy, US President Donald Trump has been urging states to lift restrictions, and many governors are doing so gradually, though consumers remain leery of going back to restaurants, social events and sporting competitions.

SOURCE 

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The Left hate us and want us out of the way

There are many on the Right, often with more, er, establishment leanings, who seem to be dismissive of the warnings we have seen from Kurt Schlichter and Dennis Prager, among others, of how much the Left hates grassroots Americans. The Never Trump faction has long been in denial of reality, and it starts with what seems to be misunderstanding the Left.

At the very least, many so-called “progressives” want Patriots to shut up and get out of the way. You don’t need to just take the word of your Patriot Post team; just look at Elizabeth Warren’s campaign platform. For her, it was not enough to pass sweeping restrictions on our Second Amendment rights, punishing millions of law-abiding Americans for crimes and acts of madness they did not commit. She wanted to sic the Internal Revenue Service on the National Rifle Association.

In her mind, the many lawmakers who defend our right to keep and bear arms do so because they are “corrupt” — the notion that another American could look at Second Amendment issues and come to a different good-faith conclusion about what policies should be pursued seems to be completely foreign to her.

Given that her presidential campaign flopped, Patriots might want to breathe a sigh of relief, but she is a top contender to be Joe Biden’s veep. Given what many speculate about Biden’s health, Warren would be a heartbeat away from being president.

Between Operation Fast and Furious, Benghazi, IRS Tea Party targeting, Wisconsin’s “John Doe” investigations, the efforts by state attorneys general to silence opponents of the “green” agenda, Spygate, and Andrew Cuomo’s jihad against the NRA, there is a clear pattern. When they are in power, Democrats have a proclivity toward using police-state tactics against their opponents.

Worse, the tactics worked. We’ll never know for sure, but those abuses undoubtedly played a part in losses over the years. Even the Supreme Court has not been immune from threats (particularly the chief justice), and in the recent Second Amendment case some justices backed down in the face of pressure.

Also coming as a harbinger of police-state tactics is the fact that, according to a report by Fox News, Department of Defense technology intended to combat radical Islamic terrorist groups is now being turned on domestic political actors — President Donald Trump’s supporters.

The Defense Advanced Research Projects Agency denies it, but after seeing what happened with Lois Lerner, Fast and Furious, and Spygate, can we really believe that denial? Once again, the past misconduct, the bureaucratic usurpation of power, and the lack of accountability raise doubts about the denial.

Given all of this, the situation should be patently obvious to anyone. Leftists have been telling us who they are and what they intend to do. The question is, do those who criticize Trump supporters not believe them, or are they being willfully blind?

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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The lockdowns still aren’t working

A few weeks ago, I wrote a piece for spiked arguing that there is little empirical evidence that regional lockdowns prevent the spread of Covid-19 better than well-done social-distancing measures. The piece received far more of a response than I expected. After literally thousands of email and Twitter comments – mostly positive – I have returned to respond to some of the more common methodological points raised by readers. Once again, I find limited – if any – evidence for the efficacy of lockdowns. My data set is available for anyone to request it via my Twitter.

The most basic response I received was that this could all change in a fortnight. The lockdowns simply needed more time to succeed. This argument has turned out to be false. As of the close of business Friday 1 May, the number of documented Covid-19 cases across the US states and territories ranged from 146 (in Guam) to 315,222 (in New York), with a per-state US average of 20,954. New York State is an outlier, so with that removed from the mix, state caseloads varied between 146 and 121,190 (New Jersey) for a mean average of 15,295.

Unlike most US states, Arkansas, Iowa, Nebraska, Oklahoma, North Dakota, South Dakota, Utah and Wyoming did not issue ‘shelter in place’ orders and have enacted social-distancing measures instead. South Carolina did eventually lock down, but not until 6 April. It was the last state to do so, locking down some three-and-a-half weeks after California and New York. It also allowed major exceptions, such as religious services. The mean for the number of cases across social-distancing states was 3,895. Without South Carolina, the mean was 3,600.

Essentially, there is the same pattern for Covid-19 deaths. On 1 May, deaths nationally ranged from seven in Wyoming up to 24,069 in New York, for a mean of 1,229 deaths per state. With New York removed, the deaths varied between seven and 7,538 (New Jersey). The mean number of cases was 789. In the non-lockdown social-distancing states, the 1 May mean for deaths was 98.9 – falling to 79.3 with South Carolina removed from the analysis.

As before, I next adjusted for population. As of 10pm EST on 1 May, officially tested Covid-19 cases per million state residents in the US ranged from a low of 435 in Montana and Hawaii up to 16,068 in New York. The per-state average was 2,882 cases-per-million, or 2,624 with New York removed. Deaths per million ranged between 11 (Hawaii) and 1,227 (New York) for a mean of 147. Without New York, this falls to 126, with New Jersey (849) as the worst-hit state. In contrast, the non-lockdown social-distancing states averaged 1,704 cases per million and only 34 deaths per million. In other words, the number of deaths in social-distancing states is just 27 per cent that of the lockdown states.

A second suggestion was that I improve my regressions, by (1) re-running them using more up-to-date cases and deaths data for my dependent variables, (2) running them with current active cases as a dependent variable, and (3) adding variables. These new variables include the rate of testing, the date the epidemic started, and even temperature. Even with these adjustments, little has changed.

First, I treated caseload and deaths as of 1 May 2020 as the dependent variables. Population, population density, ‘strategy’ (lockdown or social distancing), median age, median income and diversity (minority-population percentage) were my independent variables. The regression analysis produced results very similar to those I wrote about in my earlier spiked piece. The main difference was that with the more-up-to date figures, population density became more significant as a predictor of caseload and deaths.

Secondly, the results were almost identical when current active cases of Covid-19 were used as a dependent variable. Again, both population and density were significant predictors in the model. But the strategy used by a state to respond to Covid-19 – social distancing or lockdown – was not a significant predictor of Covid cases or deaths.

Third, I added all of the new variables suggested by spiked readers and those in the online modelling community to my regression analyses. I first regressed each of these separately against the ‘cases’ and ‘deaths’ dependent variables. The ‘state temperature’ variable had little influence. However, the ‘testing’ variable – representing the number of Covid tests administered by a state per million residents – was highly significant. The p-value for testing – the probability that its relationship with cases and deaths is down to just random chance – was only .006 for cases and .005 for deaths. The date-of-onset variable (days since the first confirmed in-state Covid death) was also significant against cases and was nearly significant against deaths (p=.026, .064).

Next, each of these variables was cycled into my original six-variable linear model. In this multivariate model, the relationships between testing rates and both cases and deaths remained statistically and meaningfully significant. In this model, the relationships between date-of-onset and the two dependent variables fell below statistical significance.

Interestingly, I observed a strong, significant and meaningful correlation between increasing temperature and decreasing Covid-19 caseload (B= -2,065, p=.029) and death totals (B = -169, p=.025). The unstandardised regression coefficient (B) means that, with all other variables adjusted for in the model, each one-degree increase in mean temperature correlated with a 2,065-unit decrease in Covid-19 cases and a 169-unit decrease in Covid deaths.

It should be prudently noted that, while the coefficients for the temperature variable remained consistent in the same direction (B = -900, -74.1), these relationships between temperature and the primary dependent variables did not reach significance (p=.199, .185) in the final model I ran – an ‘all critical variables’ regression which included population, population density, strategy, temperature, rate of testing and date-of-onset. In that model, the only conventionally significant variables were population and testing. However, the relationship between temperature and the fight against Covid-19, which has been the subject of much media speculation, should be explored in the context of data sets larger than mine.

In the context of my fairly small data set, I certainly encourage scholars to add individualised weights to the data (something I have largely resisted doing) and to try out log-linear rather than linear analyses. However, I will point out that my focus variable of government strategy has not proven to be a significant predictor of any of my dependent variables, in any model.

A final claim made against my original model is that I should compare the rates of weekly increase in Covid-19 cases and deaths. Data from day-by-day tracking resources like Covidtracking.com does indicate that, while their overall case numbers are low, states like Wyoming and South Dakota have seen major increases in their death totals during some recent weeks – 250 per cent and 300 per cent respectively.

However, the ‘surges’ we hear of in the social-distancing states tend to be tiny. Wyoming’s ‘250 per cent increase’ was a jump from two total deaths to seven. What is more, Wyoming’s death toll has remained stable at seven total deaths since 23 April – implying a zero per cent increase in death rate over the past week.

Also, other social-distancing states have done quite well against the same week-to-week metrics. Covid Tracking data for Arkansas indicate that the state’s death rate grew only from 37 to 45 between 17 April and 24 April, roughly half the increase of the week before and one of the top three performances among all states.

Finally, the varying dates-of-onset for different states indicate that regions are at different points along their epidemic curves, and this could easily affect rates of new cases and deaths in heartland states versus coastal states, regardless of response strategy.

With all that said, the fact that I have compiled two fairly solid Covid-19 data sets within a two-week period allows me to conduct a more comprehensive test of the effectiveness of lockdowns.

When I wrote my last piece for spiked, the US states overall had an average of 54 Covid-19 deaths per million persons. The social-distancing states, with South Carolina counted as a social-distancing state, had an average of 12 Covid deaths per million. As of today, that figure has jumped to 147 deaths per million for all US states (126 per million minus New York), and 34 per million for social-distancing states. Deaths per million have increased by 22 in the social-distancing states, and by 72 to 93 in the lockdown states, during only the past two weeks. This gap in new, post-lockdown deaths per million people once again suggests that the lockdowns are not working.

This should be a powerful argument for adopting social distancing. While social-distancing measures – like wearing a light medical mask or washing one’s hands 11 times a day – might be annoying, the practical impact of country-wide lockdowns has been utterly devastating. Unemployment in the US is approaching (if not surpassing) Great Depression levels. Thirty million Americans have filed jobless claims since March. Almost eight million small- to medium-sized businesses are at risk of closing permanently.

The original argument for the lockdown policies which have caused all this pain is that they were necessary to avoid an almost unprecedented wave of mass death. Early analyses from the WHO and from serious scientists estimated the infection fatality rate (IFR) for Covid to be between roughly one per cent and four per cent. They projected infection rates of up to 80 per cent, and argued that ‘mitigation’ alone would do little to stop it. Faced with the apparent prospect of corpses littering the streets, entire countries essentially shut themselves down.

Now, however, serological testing tells us that the actual IFR for Covid-19 may well be on the order of 0.3 or 0.4 per cent. Even the WHO is now lauding social-distancing Sweden as an effective model for other nations going forward. Sweden, which never locked down, currently ranks 20th in Europe in terms of cases-per-million and ninth in deaths-per-million – ahead of the locked-down UK in both categories.

None of this means that those making the case against lockdowns should do so glibly. Any human death is a tragedy. It is certainly possible that US states which lift lockdowns could see spikes in Covid-19 cases and deaths – particularly if residents do not embrace voluntary distancing. Press photographs of packed beaches and flag football games in the park are hardly manna for those of us who favour ending the lockdowns (although many of these photos have been taken during lockdowns).

It is also worth noting another unsayable fact at this point: approximately the same number of people have always been projected to contract Covid-19 in most ‘curve flattening’ scenarios. Lockdowns simply spread the deaths out across a longer period of time.

The original argument for locking down to ‘flatten the curve’ was very specifically about stopping patients from entering hospital in a single stream that would overwhelm healthcare resources and cause millions of incidental deaths. Now, however, we know that hospitals have not been swamped on a large scale in any of the non-lockdown US states, nor in nations such as Sweden which never locked down. In fact, more than 200 hospitals in lightly hit areas of both lockdown and social-distancing states have begun to furlough their employees, after cancelling elective procedures in preparation for a Covid wave that simply never arrived.

Much of this result is almost certainly explained by the IFR for Covid-19 being apparently far lower than that originally predicted. The prevalence of the virus among the population is also much higher than expected. And now that we know the hospital system has not been swamped, there is arguably no reason whatsoever to destroy our economies simply to experience roughly the same number of infections later rather than sooner.

Again, there may well be responses to these points. Given the gravity of the situation, some might seriously expect to see a Covid-19 vaccine in three to six months, rather than the usual 12 to 18. But, to be useful, any such assertions must be based on facts, rather than hope and speculation.

No single set of numbers can be perfect, but it is becoming increasingly apparent that numbers, not emotions, must guide the debate about how best to respond to Covid-19. And the numbers just discussed, human and economic, do not make the case for lockdowns.

SOURCE 

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Dear Media, Governor Kemp Will Accept Your Apology Now

When Governor Brian Kemp announced that the state of Georgia would make the initial steps toward reopening the economy, the media went on the attack. He was called irresponsible and it was predicted Georgia cases would skyrocket.

Also-ran Stacey Abrams jumped into the fray as part of her audition for Joe Biden’s vice presidential slot. She called Governor Kemp “dangerously incompetent” during a national media appearance with Gayle King. Atlanta Mayor Keisha Lance Bottoms also called the governor’s plan reckless and the media trumpeted warnings of a second wave. Even Fox’s Martha MacCallum challenged Kemp on his plan during an interview at the time:

During that interview Kemp was clear. He had worked closely with public health officials to make the decision to begin the reopening process. Kemp made it clear that the state was not given carte blanche to reopen and resume normal operations. He was also clear that the health system was bleeding money because they were empty. The outline for testing and mitigation was also laid out. MacCallum said everyone would be watching Georgia because of his early moves to implement the Phase 1 guidelines. Kemp expressed confidence in the business owners and the citizens to make good decisions and protect each other using the guidelines the state was putting out.

Well, the results are in and the media can now apologize for the savaging of my governor. Since the tentative reopening on April 24, the state has not seen a spike in the percentage of positive cases or hospitalizations. Kemp and his team are measuring this correctly.

The entire purpose of mitigation was to protect the hospital system and ensure those critically ill with COVID-19 could be adequately cared for. Georgia has a more than adequate capacity to deal with a hot spot. Despite increased testing, a lower percentage are testing positive—even with increased mobility and business operations. Given the number of asymptomatic and mild cases we know exist, measuring the results against the capacity of the healthcare system to treat severe cases is the best measure of success. Not new cases.

Additionally, like many other states, Georgia has seen a significant portion of the deaths related to coronavirus occur in nursing homes. According to an analysis done by Phil Kerpen and a colleague using state-level data, nursing homes account for 48.2% of coronavirus deaths in Georgia. Governor Kemp ordered 100 National Guard troops to assist in ensuring infection-control procedures and other protocols were being implemented in these facilities to reduce transmission and preserve hospital resources in early April. Nationwide the analysis shows that over 50% of deaths are occurring in nursing home facilities. This should be a major focus for all governors to reduce deaths and save lives.

SOURCE 

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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First at-home saliva test for COVID-19 earns FDA approval

The U.S. Food and Drug Administration (FDA) has approved the first at-home saliva collection test for COVID-19, which people could use to sample their own saliva and send it into a lab for results.

Developed by RUCDR Infinite Biologics, a biorepository based at Rutgers University in New Jersey, the test received "amended emergency use authorization" from the FDA late on May 7, according to a statement from the university. In April, the lab received emergency use authorization for their saliva collection method, which allowed health care workers to begin testing New Jersey residents at select sites throughout the state, The New York Times reported April 29.

Now, the amended authorization will allow people to collect their own saliva at home and avoid potentially risky contact with people at testing sites. The only other at-home coronavirus test on the market requires users to collect samples using a nose swab, The New York Times reported May 7.

"Collecting a saliva sample at home mitigates the risk of exposure needed to travel to a facility or drive-through and is less invasive and more comfortable and reliable than sticking a swab up your nose or down your throat," Andrew Brooks, chief operating officer and director of technology development at RUCDR, said in the statement.

When compared with swab tests for the coronavirus, which rely on samples collected from the nose and throat, the saliva-based test generated fewer false-negative results in severely infected people, meaning it was more reliable at confirming an active infection, according to the Times report published April 29. The rate at which COVID-19 swab tests deliver false-negative results has raised concerns among health care professionals, Live Science previously reported; saliva-based tests could provide consistency where these other tests have faltered.

In the same comparison, the saliva tests garnered no false-positive results, either.

During collection, a person would spit into a container holding a preservative liquid developed by the medical equipment manufacturer Spectrum Solutions, according to the Rutgers statement. The exact recipe for the solution remains a secret, but the ingredients are readily available, the Times reported. Like swab tests, however, the saliva-based test relies on PCR machines to process sampled genetic material; specific chemical reagents are needed to run the machines and could present supply chain problems, Angela Rasmussen, a virologist at Columbia University, told the Times.

That said, the at-home saliva test could address "many critical issues associated with large-scale screening that is required to get people back to their normal daily lives," Brooks said. During the month of April, the Rutgers lab processed nearly 90,000 tests conducted at their in-person testing sites and planned to increase their testing capacity to 30,000 tests a day, Brooks told the Times. At the time, test results could be delivered back to patients within 72 hours, but the turnaround time could be cut down to only a few hours with all the right infrastructure in place, according to the Times report.

Now that people can collect their own samples remotely, the Rutgers lab could feasibly process "tens of thousands of samples daily," according to the statement.

SOURCE 

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Coronavirus pandemic takes staggering toll on mental health

By Jean Twenge

When the novel coronavirus roared into the U.S., mental health took a back seat to physical health. The number one priority was making sure hospitals wouldn’t be overwhelmed and that as many lives as possible could be saved.

Schools closed, remote work became the norm, restaurants shuttered and getting together with friends was no longer possible. The news cycle spun with story after story highlighting the ever-increasing number of cases and deaths, while unemployment soared to levels not seen since the Great Depression.

Any one of these shifts could be expected to cause an increase in mental health issues. Put together, they created a a perfect storm for a crisis.

Experts speculated as much, and polls showed that many people seemed to intuitively grasp the mental toll of the pandemic. However, data on mental health metrics was scant; we didn’t know the magnitude of any changes in mental health issues, nor did we understand which groups of people were suffering more than others.

So I decided to collect data on mental health during the pandemic and compare it to data from before all of this happened. The differences were even worse than I anticipated.

A generational divide

On April 27, I surveyed 2,032 U.S. adults using a standard measure of mental distress that asks, for example, how often a respondent felt sad or nervous in the last month. I compared the responses with a sample of 19,330 demographically similar people in a 2018 government-sponsored survey of U.S. adults that asked the same questions.

The results were staggering: The 2020 participants were eight times as likely to screen positive for serious mental illness – 28%, compared to 3.4% in the 2018 survey. The vast majority of the 2020 participants, 70%, met criteria for moderate to serious mental illness, compared with 22% in 2018.

Clearly, the pandemic has had a devastating effect on mental health.

Yet some people are suffering more than others. Younger adults ages 18 to 44 – mostly iGen and millennials – have borne the brunt of the mental health effects. They’ve experienced a tenfold increase in serious mental distress compared with 2018. Meanwhile, adults 60 and older had the smallest increases in serious mental health issues.

Why might this be the case? After all, the virus has far more dire health implications for older people.

It could be because older people are more protected from the economic disruptions of the pandemic. Younger adults were more likely to lose their jobs as restaurants and stores closed and were more likely to be in a precarious financial position to begin with. The youngest adults were also already struggling with mental health issues: Depression among 18- to 25-year-olds surged from 2012 to 2017, possibly because young adults spent less time interacting with others in person than they used to, a situation only exacerbated by the pandemic.

Parents under pressure

The other group in distress won’t be a surprise to parents: those with children under 18 at home. With schools and daycares closed during the pandemic, many parents are trying to do the near-impossible by working and supervising their children at the same time. Sports, scouting, music classes, camps and virtually every other activity parents rely on to keep their kids occupied have been canceled. Even parks were closed for weeks.

This trend didn’t occur just because people with children at home are younger. Even among 18- to 44-year-olds, those with children at home showed larger increases in mental distress than those without kids.

In 2018, parents were actually less likely to be experiencing mental distress than those without children. But by the end of April 2020, parents were more likely to be in distress than their childless peers.

Where do we go from here?

The findings of this study are preliminary. The 2020 and 2018 samples, though very similar in age, gender, race and region, came from different sources and thus might differ in other ways.

However, there are also other indications that mental health is suffering during the pandemic. For example, calls to mental health hotlines appear to have surged.

SOURCE 

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Isolation Is Also Deadly

Isolation is the key to social or physical distancing aimed at curbing the transmission of COVID-19. But isolation of both the ill and symptomatic along with the well also intensifies problems with mental health, like depression. It’s impacting one key aspect of those in recovery from addictions, not to mention the deaths and diseases of despair.

Healthy social interactions range from the mundane of encountering smiling faces in our daily comings and goings to individuals who partner with a group or a counselor to overcome addictions through accountabilities. These human touches and encounters are needed in our lives for our own purpose, self-worth, camaraderie, and identity.

With the prolonged isolation of both sick and well, positive COVID cases with hospitalizations are not the only numbers that have to be considered. Deaths of despair will soon be part of the death count, though there won’t be extra COVID funding coming for those lives.

Forced unemployment in double digits has placed Americans who would never in their lives expect to receive a government unemployment check out of work. Wait, they’re told, on the population centers to stabilize their case counts and hospitalization rates. Wait on some authority to allow “nonessential businesses” — the estimated 30.2 million sole proprietors or authentic small businesses that make up more than 98% of all businesses in the U.S. — to resume operations.

Remember the opioid epidemic? Deaths of despair were characteristic of the opioid crisis, because there is a a correlation between economic instability or collapse and the increase in illicit drug use and addiction. Hence, the opioid epidemic had part of its roots in economic distress. According to the National Institutes of Health, in 2017, there were 70,000 deaths due to opioid overdoses. America didn’t close its economy but there was a mounted response to intervene and reverse course, which happened to include improved economic opportunities for millions.

Yet today, some push a straw argument in efforts to marginalize the opposition in order to keep everything locked down. It goes like this: If you want to reopen the economy, you’re greedy and want people to die. Rhetorically, the question is posed, “How many deaths are too many before it’s time to close businesses again?”

It’s not just the out-of-work adults facing despair. The Wall Street Journal’s James Freeman records several reports of increased volume at the teen suicide hotline as a result of social and physical isolation combined with family pressures within the home.

Social determinants and adverse childhood events are buzzwords in the academic community, with massive efforts to reconstruct environments to end destructive behaviors into more favorable and thriving situations. Yet the harsh polarizing defenses employed to keep strict closures and the quarantine of all — well, vulnerable, sick, and healthy — runs counter to the very foundations of these priorities when addressing children and youth in physical and mental health by addressing a variety of factors, including family income and socialization.

There was a need to understand this virus — its transmission and presentation — and to have a temporary intervention to contain and mitigate its spread. This virus from Wuhan is here to stay. But keeping businesses closed, workers unemployed, and government printing and borrowing money is neither sustainable nor healthy for adults, teens, or families. Yes, isolation kills. But it kills more than the viral transmission of a pathogen. It also kills an individual’s well-being through work, self-reliance, community, and ability to support a family.

The poison of political hatred, however, will cause a significant truth to be missed or dismissed: There’s a mountain of data and research demonstrating a wealth-health connection tying economic growth and work directly to better health and well-being.

SOURCE 

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FDA Grants Emergency Use Authorization to First Coronavirus Antigen Test

The Food and Drug Administration (FDA) has issued the first emergency use authorization to a coronavirus antigen test. The Trump administration has been working to quickly expand testing abilities, and the antigen test represents a new category of testing that can rapidly detect infections of the Wuhan coronavirus.

Public health experts have said widespread testing is paramount to safely reopening the country, and the FDA's emergency use authorization to diagnostic health care manufacturer Quidel's new coronavirus antigen test is part of that effort.

Antigen tests have the potential to test millions of Americans per day and are cheaper to produce than polymerase chain reaction (PCR) tests. Expanded testing will allow infected individuals to be quickly identified and quarantined to help stop the virus from spreading.

According to CNBC, the new tests can quickly detect protein fragments belonging on or within the virus by testing samples collected through naval cavity swabs. The test results are returned in minutes, and while the new tests can't detect all active infections, the positive test results are highly accurate. Negative test results may require additional PCR tests to confirm the subject is negative for the virus. PCR tests are more accurate but take longer to analyze.

SOURCE 

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IN BRIEF

Attorney General William Barr's office shreds NBC's Chuck Todd for "deceptive editing" of Barr's comments (The Daily Wire)

House Speaker Nancy Pelosi is reportedly drafting a $750 billion bill to aid state and local governments; Republicans aren't happy (Fox News)

Office of Special Counsel blocks removal of HHS whistleblower Dr. Rick Bright to investigate claim of "political retaliation" (National Review)

Encouraging illegal aliens to remain in the U.S. is a crime, the Supreme Court rules unanimously (The Daily Caller)

Rhode Island becomes first in Northeast bloc to lift stay-at-home order (Fox News)

Field hospitals stand down, most without treating any coronavirus patients (NPR)

Joe Biden's virtual rally in Tampa goes hilariously wrong (The Daily Wire)

Policy: The left is at war with the Little Sisters of the Poor (American Enterprise Institute)

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For more blog postings from me, see  TONGUE-TIED, EDUCATION WATCH INTERNATIONAL, GREENIE WATCH,  POLITICAL CORRECTNESS WATCH, AUSTRALIAN POLITICS, and Paralipomena (Occasionally updated), A Coral reef compendium and an IQ compendium. (Both updated as news items come in).  GUN WATCH is now mainly put together by Dean Weingarten. I also put up occasional updates on my Personal blog and each day I gather together my most substantial current writings on THE PSYCHOLOGIST.

Email me  here (Hotmail address). My Home Pages are here (Academic) or  here  (Personal).  My annual picture page is here.  Home page supplement

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