Thursday, January 26, 2023

Recent findings show that vaccination is much less protective against the latest Covid variants

A high-powered group of scientists employed at Beth Israel Deaconess Medical Center and Los Alamos National Laboratory submitted some correspondence to the New England Journal of Medicine declaring more challenges with the current mass vaccination program targeting COVID-19.

Reminding that the Omicron BA.5 variant was the predominant strain in circulation from July to November 2022, there was evidence of “substantial neutralization escapes as compared with previous variants.” This variant was followed by ensuing sublineages such as BA.4.6 as well as mutations from BA.5, including BF.7 and BQ.1.1, and mutations derived from BA.2.75.2 and the BA.2 lineages, including recombinant XBB.1. What’s in common with these variants? They all have the R346T mutation in the spike protein. Now, BQ.1.1 and XBB.1 have replaced the one dominant BA.5 around the globe. It’s not clear yet, however, how well these latest mutations evade vaccine-induced antibodies targeting the spike protein of both the original Wuhan variant and BA.5.

Enter the Study

The group of scientists embarked on a study to evaluate the neutralizing antibodies associated with the COVID-19 vaccines. The first study focused on 16 participants who were vaccinated as well as boosted with the monovalent mRNA vaccine BNT162b2 (Pfizer-BioNtech) in 2021.

Summary of findings

In the first investigation, the group looked at neutralizing antibody titers before and after receipt of the monovalent mRNA booster 2021 in 16 subjects finding:

“The median neutralizing antibody titers to the BQ.1.1 and XBB.1 variants were lower than the median titer to BA.5 by factors of 3 and 8, respectively.”

Study number two and three centered on neutralizing antibody titers before and after receipt of the monovalent mRNA booster as well as the bivalent booster in 2022. With 15 and 18 participants, respectively, a majority of the subjects had received three previous doses of the COVID-19 vaccine.

A third of the participants were infected with Omicron, but this was likely due to the high prevalence of circulation and ensuing infection in 2022.

The authors write:

“The median neutralizing antibody titers to the BQ.1.1 and XBB.1 variants were lower than the median titers to BA.5 by factors of 7 and 17, respectively, in the monovalent booster cohort and by factors of 7 and 21, respectively, in the bivalent booster cohort.”

Unfortunately, the authors continue:

“Our data show that the BQ.1.1 and XBB.1 variants escaped neutralizing antibodies substantially more effectively than the BA.5 variant by factors of 7 and 17, respectively, after monovalent mRNA boosting and by factors of 7 and 21, respectively after bivalent mRNA boosting. The neutralizing antibody titers to BQ.1.1 and XBB.1 were dramatically lower than titers to the WA1/2020 strain by factors of 53 and 127, respectively, in the monovalent booster cohort and by factors of 80 and 232, respectively, in the bivalent booster cohort.”


These findings suggest that the BQ.1.1 and XBB.1 variants may reduce the efficacy of current mRNA vaccines and that vaccine protection against severe disease with these variants may depend on CD8 T-cell responses.”

The spike in neutralizing antibody titers against omicron variants associated with the monovalent boost in 2022 over 2021 suggests an accumulation of vaccination and natural immunity linked to prior infection, which was frequent.

Is convergent evolution a result of the propagation of the R346T mutation across variants? The authors believe so. This study again emphasizes the challenges with the current mass COVID-19 vaccine strategy chasing variants of concern.


Bivalent Boosters Creating Adverse Childhood Experiences in Kids Ages 5-11

We often remember events from our childhood that came from physical experiences, such as a broken arm or falling into a stream. Most patients from yesteryear remember childhood rheumatic or scarlet fever. Parents bringing their children aged 5-11 years for COVID-19 vaccination may be creating adverse childhood experiences based on the most recent CDC safety data published by Hause et al. in MMWR:

"Safety Monitoring of Bivalent COVID-19 mRNA Vaccine Booster Doses Among Children Aged 5-11 Years - United States, October 12-January 1, 2023"

Moderna, which had greater frequency of adverse events than Pfizer, for example, caused 30% of children to have fever and vomit. Combined, 22% reported that boosters had a negative health impact, 14% could not perform daily activities to return to school, and 2% were so sick they required acute medical care. Adverse childhood experiences can have lasting social and psychological ramifications later in life, particularly if they are repeated.

No vaccine, no matter how theoretically compelling, should be in public use with these symptomatic side effects. Vaccines should have acceptable safety profiles with <5% having any significant short-term symptoms, be safe over the long term, provide at least 50% protection against a disease, inhibit transmission, and last at least a year.

Faulty vaccines that underperform or make our kids sick should be rejected by parents and removed from the market to protect public safety.


Australia: Conservative minor party to host controversial Covid sceptic

Clive Palmer’s United Australia Party will host a series of coronavirus vaccine conferences next month headlined by controversial American cardiologist Doctor Peter McCullough

Nations across the globe have “completely de-emphasised and almost obfuscated” effective coronavirus treatments in their public health approach to the pandemic, says professor of medicine Dr Peter McCullough.

Doctor Peter McCullough has been heavily criticised for controversial views on the coronavirus, with calls from some quarters for Australian immigration officials to deny him a visa to enter the country.

Numerous health officials and websites have criticised Dr McCullough, who gained widespread attention after an appearance on the podcast of American personality Joe Rogan where he made a series of provocative claims, including that the pandemic was planned as part of a conspiracy.

Several health industry websites have devoted sections to debunking Dr McCullough’s claims, which include statements that masks were useless against Covid and that test subjects in an Australian vaccination trial contracted HIV.

However, speaking on the Gold Coast on Tuesday, Mr Palmer said it was time to hear different points of view on the pandemic and vaccines and he expected conferences on the Gold Coast and Sunshine Coast to sell out. He said Dr McCullough was a “well respected” cardiologist with “impeccable” credentials.

Mr Palmer, a high-profile opponent of coronavirus vaccines, said he was told he “had six hours to live” at one point during his own Covid health battle, but was treated with alternative therapies in hospital.




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