Monday, August 28, 2023

Will Heavily COVID-19 Vaccinated Populations Experience High Incidence of Cancer & Autoimmune Disease?

A frequent contributor to TrialSite, Geert Vanden Bossche, the Belgium-based vaccinologist has spent the last few years of the pandemic intensely studying not only SARS-CoV-2 and mass vaccination but also the immunological considerations, and risks, associated with the vaccination drives.

In this latest paper “Immunological correlates of vaccine breakthrough infections caused by SARS-CoV-2 variants in highly C-19 vaccinated populations,” Vanden Bossche unleashes a truly dark, complex, and what he believes is thorough hypotheses suggesting heavily COVID-19 vaccinated populations will experience crisis levels of cancer and autoimmune disease.

Why will this tragedy occur? According to Vanden Bossche, “In highly Covid-19 (C-19) vaccinated populations, an increase in IgG4 antibody (Ab) titers following steric immune refocusing (SIR)- enabling PNNAb1-dependent vaccine breakthrough infections (VBTIs) with infectious SARS-CoV-2 (SC-2) immune escape variants promoted generalized hyposensitization to ‘foreign’ and hypersensitization to ‘self’.” Arguing that the process of hyposensitization (train immune system to become less reactive to allergen over time) “to ‘foreign’ leads to an “anti-inflammatory effect” and thus reducing the prospect for autoimmune-like disease symptoms, so-called ‘hypersensitization’ (heightened immune reaction) to ‘self’ will lead to surges in incidence of cancer and autoimmune disease.

Vanden Bossche’ s hypothesis suggests that in a highly COVID-19 vaccinated populations, there is a greater incidence of cancer and autoimmune disease. Looking into surges of IgG4 antibody titers first should be understood.

A subclass of immunoglobulin G (IgG) antibodies which are a type of antibody generated by the immune system to help protect the body against infections and other foreign substances, they play a crucial role in the immune response by recognizing and binding to specific antigens, such as bacteria, viruses and other pathogens.

TrialSite recently summarized research out of Hungary suggesting that COVID-19 vaccines trigger higher levels of spike specific IgG than persons infected with SARS-CoV-2, the virus behind COVID-19.

This was according to a team of physicians and scientists employed in Internal Medicine and the Immunology and Hematology Research Group in Semmelweis University- Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest Hungary. They investigated the SARS-CoV-2 infection and the vaccination induced a similar spike-specific IgG subclass pattern. With this study involving 47 healthy volunteers for the vaccinated cohort in Budapest Hungary, an important aim was to determine if these patterns have been influenced by the chronological order of natural virus infection and vaccination or not. Also monitoring the concentration of each spike-specific IgG subclass over a three-to-four-month period the Budapest-based investigators sought to estimate the stability of the antiviral humoral immune response.

Importantly, IgG 4 antibodies are generally less understood than other subclasses of IgG. Involved in immune tolerance, and with anti-inflammatory properties, IgG4 responses are associated with chronic infections, allergies and autoimmune diseases. Interestingly, unlike other subclasses, IgG4 antibodies can undergo a process called “Fab-arm exchange” where the arms of two different IgG4 antibodies can be swapped, potentially altering their function.

Back to Vanden Bossche, with an increase in IgG4 titers due to what he describes as “steric immune refocusing” (SIR), defined in another paper of his as “re-orientation of the humoral S-directed immune response towards more conserved, immune subdominant S-associated epitopes as a result of steric masking of variable, immunodominant S protein-associated epitopes by pre-existing, low-affinity pNAbs” the latter signifying human performed natural antibodies.

So, PNNAb1-dependent vaccine breakthrough infections or “VBTIs” lead to “infectious SARS-CoV-2 (SC-2) immune escape variants promoted generalized hyposensitization to ‘foreign’ and hypersensitization to ‘self’, inducing carcinogenicity and autoreactivity.”

Not a good development if this comes true. Vanden Bossche is known for predicting select adverse outcomes as a result of the ongoing mass COVID-19 vaccination approach to the pandemic. For example, the Belgium-based vaccinologist predicted that introducing mass vaccination in the midst of the SARS-Cov-2 pandemic would place great evolutionary pressures on the pathogen, supporting the evolutionary process. Most certainly SARS-Cov-2 mutated into many different variants and strains. However, we can’t be sure if it's due to Vanden Bossche’ s hypothesis but it should be vetted by experts in the field.

But ominously, here in heavily vaccinated populations Vanden Bossche’s hypothesis suggests a tragic explosion in cancer and autoimmune disease.

That's because according to his hypothesis, “SIR-enabling VBTIs, but also mRNA vaccination, facilitates immune refocusing to more conserved, immune subdominant spike (S)-associated epitopes.” Remember, epitopes are specific regions on the surface of antigens to which antibodies or immune cells bind. They play a crucial role in the immune system’s ability to recognize and respond to foreign substances such as viruses.

So, what’ s a key part of this mechanism that leads to serious trouble—namely higher incidence of cancer and autoimmune disease?

According to Vanden Bossche’ s paper, “delayed maturation of these de novo (new) primed, subneutralizing Abs into isotype-switched IgG4 anti-S Abs enables prolonged immune pressure on viral infectiousness.” What does this do? It leads to real trouble in the form of “promoting large-scale co-circulation of more infectious SC_2 immune escape variants.”

It is a cascade of immune selection events that “eventually mitigate disease caused by SC-2 and other unrelated viral pathogens (via anti-inflammatory IgG4)” leads to viral dissemination.

Vanden Bossche hypothesizes that “acute autoimmune disease and early-onset cancer in highly C-19 vaccinated populations are due to VBTI-or mRNA vaccine-mediated immune refocusing to more conserved, poorly immunogenic ‘self-like’ epitopes.


Sen. Johnson Sounds Alarm on Return of COVID-19 Mask Mandates

Sen. Ron Johnson (R-Wis.) is sounding the alarm after a small number of offices, hospitals, and schools reinstated mask mandates in recent days.

Describing the mandates as “alarming,” Mr. Johnson told the Moms for Liberty group on Aug. 23 that they are ineffective and said he would keep fighting them.

“It’s alarming that the mandates are kicking in again,” he told the group. “It’s like, OK, we noticed masks didn’t work, particularly for children. We always knew they didn’t work for kids.”

The Wisconsin Republican said, “N-95 masks can have some marginal benefits—but not to deny people freedom.”

Mr. Johnson has said he was always skeptical of federal vaccine mandates and has been an advocate for people who claimed to have been injured by COVID-19 vaccines. He also called on the Biden administration to admit that its COVID-19 policies didn’t work.

“They’ll never admit they were wrong in how they handled COVID. I don’t see how anybody can take a look at how the federal government—really, over the course of two administrations—how they handled COVID, and say it was anything but a complete and miserable failure,” he told the Washington Examiner in May.

The White House, the senator added, won’t acknowledge what he described as the “the incalculable human toll” and the “economic devastation caused by the shutdowns.”

Mr. Johnson’s recent remarks come after Hollywood studio Lionsgate said in a memo earlier this week that it would reimpose a mask mandate for several floors of its office in Santa Monica, California.

“Employees must wear a medical grade face covering (surgical mask, KN95 or N95) when indoors except when alone in an office with the door closed, actively eating, actively drinking at their desk or workstation, or if they are the only individual present in a large open workspace,” a Lionsgate manager said in a memo, reported by Deadline.

This week, Kaiser Permanente Hospital in Santa Rosa, California, and the Upstate Community Hospital in Syracuse, New York, brought back the masking rule for visitors, patients, nurses, and doctors.

“To ensure that we are helping protect the health and safety of our patients, our workforce, and our community, we have reintroduced a mask mandate for physicians, staff, patients, members, and visitors in the hospital and medical offices in the Santa Rosa Service Area,” Kaiser Permanente said.

Morris Brown College in Atlanta also said that masks will again be required on campus because of a rise in cases on a larger campus in Atlanta.

“There will be no parties or large student events on campus for the next two weeks,” the school said.

At the same time, there has been an increase in media coverage of several COVID-19 variants, including one that the U.S. Centers for Disease Control and Prevention (CDC) stated could potentially evade vaccines. No federal agencies have announced any new mask mandates or recommendations.

Media Coverage

In recent days, an increasing number of television doctors have made suggestions that some people start masking again.

“It’s riskier that you will get infected now than it was a month or two ago, without question, probably twice as risky,” Dr. Bob Wachter, chair of medicine at the University of San Francisco, told CNN in a recent interview. “If you’re trying to be careful, it’s time to whip out the mask again.”

Also appearing on CNN, Dr. Jonathan Reiner, a cardiologist in Washington, said on Aug. 22 that people who are at risk from a COVID-19 infection—including people aged 65 and older—should put masks on again. He also said that President Joe Biden should do so, too.

“Octogenarians comprise the highest-risk group for complications following COVID infection,” he said. “At least until the numbers start to drop again, it would be appropriate for President Biden to take some precautions and wear a mask in crowds.”

Last week, COVID-19 hospitalizations rose across the country, according to data from the CDC. Hospitalizations rose by 21.6 percent, to 12,612 new admissions from 10,370, according to the data ending Aug. 12.

Despite the increase, it’s among the lowest levels of hospitalization recorded since the start of the pandemic in early 2020.

“An upswing is not a surge; it’s not even a wave,” Dr. Shira Doron, the chief infection control officer for Tufts Medicine, told ABC News this week. “What we’re seeing is a very gradual and small upward trajectory of cases and hospitalizations, without deaths really going along, which is great news.”




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